scholarly journals Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs

2014 ◽  
Vol 548 ◽  
pp. 74-85 ◽  
Author(s):  
Jiansheng Huang ◽  
Forrest Smith ◽  
Peter Panizzi
Keyword(s):  
Benzoic Acid ◽  
Active Site ◽  
Acid Hydrazide ◽  
Benzoic Acid Hydrazide

Four-Component Reaction between Trimethyl Phosphite, Aroyl Chlorides and Dialkyl Acetylenedicarboxylate with Benzoic Acid Hydrazide

2011 ◽  
Vol 35 (9) ◽  
pp. 516-518 ◽  
Author(s):  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin ◽  
Mohammad Anary-Abbasinejad ◽  
Farzaneh Ghazvininejad ◽  
Somayeh Koocheki
Keyword(s):  
Benzoic Acid ◽  
Acid Hydrazide ◽  
Trimethyl Phosphite ◽  
Dialkyl Acetylenedicarboxylate ◽  
Benzoic Acid Hydrazide

scholarly journals Inactivation of myeloperoxidase by benzoic acid hydrazide

2015 ◽  
Vol 570 ◽  
pp. 14-22 ◽  
Author(s):  
Jiansheng Huang ◽  
Forrest Smith ◽  
Jennifer R. Panizzi ◽  
Douglas C. Goodwin ◽  
Peter Panizzi
Keyword(s):  
Benzoic Acid ◽  
Acid Hydrazide ◽  
Benzoic Acid Hydrazide

Effect of Platinum(II) Complexes of 4-Methoxy-and 4-Chlorobenzoic Acid Hydrazides on Saccharomyces cerevisiae

1997 ◽  
Vol 52 (1-2) ◽  
pp. 45-48 ◽  
Author(s):  
Svoboda Tabakova ◽  
Nicolay Dodoff
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Complex Formation ◽  
Benzoic Acid ◽  
Mechanism Of Action ◽  
Acid Hydrazide ◽  
Complex Activity ◽  
Chlorobenzoic Acid ◽  
The Stability ◽  
Benzoic Acid Hydrazide ◽  
Methoxybenzoic Acid

This study reports the anti-yeast effect of the 4-methoxybenzoic acid hydrazide (pmbah), 4-chlorobenzoic acid hydrazide (pcbah) and their Pt(II) complexes: cis- [PtL2X2] and cis- [PtL(NH3)Cl2] where L is either pcbah or pmbah and X is Cl, Br or I. MICs of the 4- substituted analogues (20 000-625 μм) are much lower than those of the previously reported benzoic acid hydrazide and 3-methoxybenzoic acid hydrazide. Complex formation results in significant increase of potency which may be due to a change in the mechanism of action, but the MIC (>400-50 μм) and the IC50 (>400-1 μм) values show that higher activity of the ligands in the free state does not result in enhanced complex activity. Differences in the potency of iodo-, chloro- and bromo complexes suggest MIC and IC50 values may be in correlation with the stability of the complex, rather than with the activity of the free ligands. Osmotically unstable mutants were more susceptible to the compounds than their parent strains, but differences among the parent strains were greater.

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