The potent insulin secretagogue effect of betulinic acid is mediated by potassium and chloride channels

2018 ◽  
Vol 648 ◽  
pp. 20-26 ◽  
Author(s):  
Allisson Jhonatan Gomes Castro ◽  
Luisa Helena Cazarolli ◽  
Lizandra C. Bretanha ◽  
Paola Miranda Sulis ◽  
Diana Patricia Rey Padilla ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Chloride Channels ◽  
Insulin Secretagogue

In vivo toxicological evaluations for betulinic acid and ramified cyclodextrins applied on experimental melanoma models

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CA Dehelean ◽  
C Peev ◽  
C Soica ◽  
S Cinta-Pinzaru ◽  
Z Aigner
Keyword(s):  
Betulinic Acid

Identification and isolation of betulin, betulinic acid and lupeol from birch bark

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
E Kovac-Besovic ◽  
K Duric ◽  
Z Kaloðera ◽  
E Sofic
Keyword(s):  
Betulinic Acid ◽  
Birch Bark

NOXA as Target for the Combination Therapy of Betulinic Acid and Conventional Cytotoxic Drugs

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
I Jeremias ◽  
H Ehrhardt ◽  
I Höfig ◽  
N Terziyska ◽  
P Obexer
Keyword(s):  
Combination Therapy ◽  
Betulinic Acid ◽  
Cytotoxic Drugs

A novel insulin secretagogue is a phosphodiesterase inhibitor

Diabetes ◽  
1995 ◽  
Vol 44 (1) ◽  
pp. 67-74 ◽  
Author(s):  
M. D. Leibowitz ◽  
C. Biswas ◽  
E. J. Brady ◽  
M. Conti ◽  
C. A. Cullinan ◽  
...  
Keyword(s):  
Phosphodiesterase Inhibitor ◽  
Insulin Secretagogue

Lupane Type Triterpene Isolated from the Leaves of Thecacoris Annobonea (Euphorbiaceae)

2013 ◽  
Vol 12 (10) ◽  
pp. 695-701
Author(s):  
Herve Martial Poumale Poumale ◽  
Alphonsine Nkapwa Guedem ◽  
Louis Pergaud Sandjo ◽  
Bonaventure Tchaleu Ngadjui ◽  
Yoshihito Shiono
Keyword(s):  
Antimicrobial Activity ◽  
Root Growth ◽  
Betulinic Acid ◽  
Aristolochic Acid ◽  
2D Nmr ◽  
Aristolochic Acid I

A new lupane type triterpene (1), together with betulinic acid (2), friedelin (3), aristolochic acid I (4), alpinumisoflavone (5) and 4’-O-methylepinumisoflavone (6) have been isolated from the leaves of Thecacoris annobonea. The structure of the new compound was elucidated on the basis of 1 and 2D NMR experiments. The isolated compounds were evaluated for their phytotoxicity and antimicrobial activity. 1 exhibited significant antimicrobial activity at 30 μg/ml and compounds 1, 2, 3, 4, 5 and 6 inhibited root growth lettuce at 100 μg/ml. 

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