Structural studies of Staphylococcus aureus Sortase inhibiton via Conus venom peptides

2019 ◽  
Vol 671 ◽  
pp. 87-102 ◽  
Author(s):  
Saima Younis ◽  
Sameera Taj ◽  
Sajid Rashid
Keyword(s):  
Staphylococcus Aureus ◽  
Structural Studies ◽  
Venom Peptides ◽  
Conus Venom

Synthesis and structural studies of 1-phenyl-1,3-butanedione copper(II) complexes as an excellent antimicrobial agent against methicillin-resistant Staphylococcus aureus

2019 ◽  
Vol 484 ◽  
pp. 227-236 ◽  
Author(s):  
Hema M. Krishnegowda ◽  
Chimatahalli S. Karthik ◽  
Manukumar H. Marichannegowda ◽  
Karthik Kumara ◽  
Pampa J. Kudigana ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agent ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Structural Studies ◽  
Methicillin Resistant

scholarly journals A perspective on toxicology of Conus venom peptides

2015 ◽  
Vol 8 (5) ◽  
pp. 337-351 ◽  
Author(s):  
Palanisamy Satheesh Kumar ◽  
Dhanabalan Senthil Kumar ◽  
Sundaresan Umamaheswari
Keyword(s):  
Venom Peptides ◽  
Conus Venom

scholarly journals Structural insights into the intermolecular interaction of the adhesin SdrC in the pathogenicity of Staphylococcus aureus

2021 ◽  
Vol 77 (2) ◽  
pp. 47-53
Author(s):  
Junchao Wang ◽  
Min Zhang ◽  
Mingzhu Wang ◽  
Jianye Zang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Intermolecular Interaction ◽  
Medical Equipment ◽  
Cell Attachment ◽  
Surface Protein ◽  
Structural Studies ◽  
Toxic Shock ◽  
Opportunistic Disease ◽  
Bacterial Aggregation ◽  
Structural Insights

Staphylococcus aureus is an opportunistic disease-causing pathogen that is widely found in the community and on medical equipment. A series of virulence factors secreted by S. aureus can trigger severe diseases such as sepsis, endocarditis and toxic shock, and thus have a great impact on human health. The transformation of S. aureus from a colonization state to a pathogenic state during its life cycle is intimately associated with the initiation of bacterial aggregation and biofilm accumulation. SdrC, an S. aureus surface protein, can act as an adhesin to promote cell attachment and aggregation by an unknown mechanism. Here, structural studies demonstrate that SdrC forms a unique dimer through intermolecular interaction. It is proposed that the dimerization of SdrC enhances the efficiency of bacteria–host attachment and therefore contributes to the pathogenicity of S. aureus.

scholarly journals High Level Expression and Purification of Atl, the Major Autolytic Protein ofStaphylococcus aureus

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Vineet K. Singh
Keyword(s):  
Staphylococcus Aureus ◽  
Structural Properties ◽  
Biofilm Formation ◽  
Structural Studies ◽  
Ofstaphylococcus Aureus ◽  
Expression And Purification ◽  
High Level Expression ◽  
Over Expression ◽  
Important Protein ◽  
High Level

Staphylococcus aureusis a major human and animal pathogen. Autolysins regulate the growth, turnover, cell lysis, biofilm formation, and the pathogenicity ofS. aureus. Atl is the major autolysin inS. aureus. The biochemical and structural studies of staphylococcal Atl have been limited due to difficulty in cloning, high level overexpression, and purification of this protein. This study describes successful cloning, high level over-expression, and purification of two forms of fully functional Atl proteins. These pure proteins can be used to study the functional and structural properties of this important protein.

NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus

2020 ◽  
Vol 49 (3-4) ◽  
pp. 223-230 ◽  
Author(s):  
Alexander Golubev ◽  
Bulat Fatkhullin ◽  
Azat Gabdulkhakov ◽  
Aydar Bikmullin ◽  
Liliya Nurullina ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Elongation Factor ◽  
Structural Studies ◽  
Elongation Factor P

Repurposing an Ancient Protein Core Structure: Structural Studies on FmtA, a Novel Esterase of Staphylococcus aureus

2019 ◽  
Vol 431 (17) ◽  
pp. 3107-3123 ◽  
Author(s):  
Vikram Dalal ◽  
Pramod Kumar ◽  
Gaddy Rakhaminov ◽  
Aneela Qamar ◽  
Xin Fan ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Core Structure ◽  
Structural Studies ◽  
Protein Core ◽  
Novel Esterase
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