Content uniformity determination of pharmaceutical tablets using five near-infrared reflectance spectrometers: A process analytical technology (PAT) approach using robust multivariate calibration transfer algorithms

2008 ◽  
Vol 611 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Yusuf Sulub ◽  
Rosario LoBrutto ◽  
Richard Vivilecchia ◽  
Busolo Wa Wabuyele
Keyword(s):  
Near Infrared ◽  
Multivariate Calibration ◽  
Process Analytical Technology ◽  
Content Uniformity ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance ◽  
Calibration Transfer ◽  
Pharmaceutical Tablets ◽  
Analytical Technology

The Rapid, At-Line Determination of Starch Content in Sucrose–Starch Blends Using Near-Infrared Reflectance Spectroscopy; A Process Analytical Technology Initiative

2005 ◽  
Vol 13 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Brad Swarbrick ◽  
Bronwyn Grout ◽  
James Noss
Keyword(s):  
Near Infrared ◽  
Process Analytical Technology ◽  
Starch Content ◽  
Spectroscopic Method ◽  
Laboratory Method ◽  
Content Uniformity ◽  
Testing Time ◽  
Near Infrared Reflectance ◽  
Starch Blends

A near infrared (NIR) reflectance spectroscopic method was developed for the rapid determination of starch content in the excipient material sucrose special powder, 4.6% starch. It was previously determined that the variability of starch content in individual bags within each delivery of this material was high. This required appropriate sample selection to provide a controlled content of starch before use in the pharmaceutical industry. Therefore, an NIR method was developed to reduce long laboratory testing time and to facilitate testing of the starch content of the material at-line in the receiving warehouse, [standard error of prediction ( SEP)NIR = 0.16% compared with 0.15% for the laboratory method]. Another important feature of the NIR starch model was its use as an at-line tool for in-house blending of sucrose–starch blends to determine blend homogeneity. In one particular application, a sucrose–starch blend, known to contain low starch levels, was spiked with commercially available starch and blended. The NIR method was used to make rapid decisions on content uniformity and the results obtained were in close agreement with laboratory assay data (mean starch content using the NIR method 4.5% compared with 4.6% for the laboratory method).

Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool

Talanta ◽  
2015 ◽  
Vol 144 ◽  
pp. 1352-1359 ◽  
Author(s):  
Pierre-François Chavez ◽  
Pierre-Yves Sacré ◽  
Charlotte De Bleye ◽  
Lauranne Netchacovitch ◽  
Jérôme Mantanus ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Pharmaceutical Tablets ◽  
Content Determination ◽  
Technology Tool ◽  
Analytical Technology ◽  
Active Content
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