Three-step drug extraction from a single sub-millimeter segment of hair and nail to determine the exact day of drug intake

AbstractAim of the present study was to investigate the effects of ongoing treatment with DOACs on time from trauma to surgery and on in-hospital clinical outcomes (blood losses, need for transfusion, mortality) in patients with hip fracture. Moreover we evaluated the adherence to current guidelines regarding the time from last drug intake and surgery. In this observational retrospective study clinical records of patients admitted for hip fracture from January 2016 to January 2019 were reviewed. 74 patients were in treatment with DOACs at hospital admission. Demographic data, comorbidities and functional status before trauma were retrieved. As control group we evaluated 206 patients not on anticoagulants matched for age, gender, type of fracture and ASA score. Time to surgery was significantly longer in patients treated with DOACs (3.6 + 2.7 vs. 2.15 ± 1.07 days, p < 0.0001) and treatment within 48 h was 47% vs. 80% in control group (p < 0.0001). The adherence to guidelines’ suggested time from last drug intake to surgery was 46%. Neither anticipation nor delay in surgery did result in increased mortality, length of stay or complication rates with the exception of larger perioperative blood loss (Hb levels < 8 g/dl) in DOACs patients (34% vs 9% p < 0.0001). Present results suggest that time to surgery is significantly longer in DOAC patients in comparison to controls and adherence to guidelines still limited.

Download Full-text

Drug extraction. IX. The Efficiency of Repercolation for Belladonna root and Nux Vomica**Scientific Section, A. Ph. A,. Portland meeting, 1935.,11This investigation was aided by a grant from the American Pharmaceutical Association Research Fund.

The Journal of the American Pharmaceutical Association (1912) ◽

10.1002/jps.3080250504 ◽

1936 ◽

Vol 25 (5) ◽

pp. 391-393

Author(s):

William J. Husa ◽

C.L. Huyck

Keyword(s):

Research Fund ◽

Scientific Section ◽

Drug Extraction ◽

American Pharmaceutical Association

Download Full-text

Drug Extraction. III. The Function of Preliminary Maceration in Relation to the Percolation of Belladonna Root121Presented before the Scientific Section, A. PH. A., Washington, D. C., 1934.2This paper is based on a thesis presented to the Graduate Council of the University of Florida by S. B. Yates, in partial fulfilment of the requirements for the degree of Master of Science in Pharmacy.

The Journal of the American Pharmaceutical Association (1912) ◽

10.1002/jps.3080240704 ◽

1935 ◽

Vol 24 (7) ◽

pp. 538-543

Author(s):

William J. Husa ◽

S.B. Yates

Keyword(s):

University Of Florida ◽

Master Of Science ◽

Scientific Section ◽

Drug Extraction ◽

The University

Download Full-text

Outcome of Medication Overuse Headache after Abrupt in-Patient withdrawal

Cephalalgia ◽

10.1111/j.1468-2982.2006.01073.x ◽

2006 ◽

Vol 26 (5) ◽

pp. 589-596 ◽

Cited By ~ 33

Author(s):

G Relja ◽

A Granato ◽

A Bratina ◽

RM Antonello ◽

M Zorzon

Keyword(s):

Medication Overuse ◽

Medication Overuse Headache ◽

Primary Headache ◽

Drug Intake ◽

Patient Withdrawal ◽

Abrupt Discontinuation ◽

Medication Abuse ◽

Daily Headache ◽

Mean Time

One hundred and one patients suffering from chronic daily headache (CDH) and medication overuse were treated, in an in-patient setting, with abrupt discontinuation of the medication overused, intravenous hydrating, and intravenous administration of benzodiazepines and ademetionine. The mean time to CDH resolution was 8.8 days. The in-patient withdrawal protocol used was effective, safe and well tolerated. There was a trend for a shorter time to CDH resolution in patients who overused triptans ( P = 0.062). There was no correlation between time to CDH resolution and either the type of initial primary headache or duration of medication abuse, whereas time to CDH resolution was related to daily drug intake ( P = 0.01). In multiple regression analysis, daily drug intake, age and type of medication overused were independent predictors of time to CDH resolution. At 3-months' follow-up, no patient had relapsed and was again overusing symptomatic medications.

Download Full-text