Membrane Curvature and Connective Fiber Alignment in Guinea Pig Round Window Membrane

2021 ◽  
Author(s):  
Miguel Arriaga ◽  
Daniel N. Arteaga ◽  
Dimitrios Fafalis ◽  
Michelle Yu ◽  
Xun Wang ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Round Window ◽  
Membrane Curvature ◽  
Round Window Membrane ◽  
Fiber Alignment

Effects of lonomer Cement on Guinea Pig Cochleas

1997 ◽  
Vol 76 (4) ◽  
pp. 223-230 ◽  
Author(s):  
Taisuke Kobayashi ◽  
Yasuyuki Hinohira ◽  
Masamitsu Hyodo ◽  
Goran Bredberg ◽  
Edel Alsterborg
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Morphological Study ◽  
Round Window ◽  
Cell Loss ◽  
Round Window Membrane ◽  
Hair Cell Loss ◽  
Ear Surgery ◽  
Hearing Thresholds

The inner ear toxicity of ionomeric cement (lonocem®) when used as a reconstructive material in ear surgery was evaluated in 47 guinea pigs used in a morphological study. The cement was implanted on either the promontory, the round window membrane or the stapes. There was no significant hair cell loss compared with the control ear at three weeks, two months or three months after implantation. Using electrocochleography, the hearing thresholds before, and three weeks, two and three months after the implantation were compared in an additional seven animals. No evident hearing loss was observed in any animal during the study period. No morphological or functional evidence for an ototoxic effect of the ionomeric cement was found in this study.

Subepithelial Fiber Components of the Round Window Membrane of the Guinea Pig: An Ultrastructural and Immunohistochemical Study

ORL ◽  
1995 ◽  
Vol 57 (3) ◽  
pp. 115-121 ◽  
Author(s):  
Toshio Yoshihara ◽  
Hidemi Kaname ◽  
Tetsuo Ishii ◽  
Makoto Igarashi
Keyword(s):  
Guinea Pig ◽  
Immunohistochemical Study ◽  
Round Window ◽  
Round Window Membrane ◽  
Fiber Components

TGFα passage through guinea pig round window membrane

1997 ◽  
Vol 117 (2) ◽  
pp. P72-P72
Author(s):  
M WITTE ◽  
J KASPERBAUER
Keyword(s):  
Guinea Pig ◽  
Round Window ◽  
Round Window Membrane

scholarly journals Adenoviral–mediated Hath1–EGFP gene transfer into guinea pig cochlea through intact round window membrane

2008 ◽  
Vol 3 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Chen Wei ◽  
Hu Yin–yan ◽  
Yang Shi–ming ◽  
Guo Wei ◽  
Sun Jian–he ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Guinea Pig ◽  
Round Window ◽  
Round Window Membrane ◽  
Egfp Gene ◽  
Guinea Pig Cochlea

scholarly journals Analysis of the Damage Mechanism Related to CO2 Laser Cochleostomy on Guinea Pig Cochlea

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Xiang Liu ◽  
Xiao-qing Qian ◽  
Rui Ma ◽  
Fang-Lu Chi ◽  
Dong-Dong Ren
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Round Window ◽  
Organ Of Corti ◽  
Damage Mechanism ◽  
Round Window Membrane ◽  
Control Group ◽  
Guinea Pig Cochlea ◽  
Brainstem Response ◽  
Laser Induced Damage

Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO2 laser (10 W, 606 J/cm2) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO2 laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and β-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated β-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.

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