scholarly journals The Role of Epidermal Stem Cells in the Origin of Basal Cell Carcinoma

2016 ◽  
Vol 107 (4) ◽  
pp. 341-342
Author(s):  
L. Prieto-Torres ◽  
S. Hernández-Ostiz ◽  
E. Pelegrina-Fernández ◽  
C. Conejero del Mazo
Keyword(s):  
Stem Cells ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Epidermal Stem Cells

scholarly journals Role of CRD-BP in the Growth of Human Basal Cell Carcinoma Cells

2014 ◽  
Vol 134 (6) ◽  
pp. 1718-1724 ◽  
Author(s):  
Felicite K. Noubissi ◽  
TaeWon Kim ◽  
Tisha N. Kawahara ◽  
William D. Aughenbaugh ◽  
Eric Berg ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma Cells ◽  
Human Basal Cell Carcinoma

scholarly journals Diagnostic and pathogenetic role of café-au-lait macules in nevoid basal cell carcinoma syndrome

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Giovanni Ponti ◽  
Aldo Tomasi ◽  
Lorenza Pastorino ◽  
Cristel Ruini ◽  
Carmelo Guarneri ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Pathogenetic Role

scholarly journals The Role of Fine-Needle Aspiration Cytology in the Diagnosis of Basal Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Masoom Kassi ◽  
Pashtoon Murtaza Kasi ◽  
Abaseen Khan Afghan ◽  
Shah Mohammad Marri ◽  
Mahwash Kassi ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background/Aims. Basal cell carcinoma (BCC) is the most common malignant tumor of the skin in humans. The diagnosis of BCC is made clinically, which can then be confirmed microscopically. Biopsy or surgical excision of the lesion provides the specimen for histopathological examination, which is the mainstay for diagnosis. Fine-needle aspiration cytology (FNAC) on the other hand is an even simpler procedure, which can provide accurate diagnosis to confirm or exclude the malignancy. Methods. Here, we present our experience on the role of FNAC in diagnosing BCC. We were able to recruit 37 patients, of which 35 had BCC. Both FNAC and biopsy were obtained and then interpreted independently of one another. Results. Cytology correlated with histopathology in all cases except for 2 in which the yield was deemed inadequate. The sensitivity and specificity of fine-needle aspiration cytology for basal cell carcinoma were 94.3% and 100%, respectively. Conclusions. We, therefore, recommend this technique for the initial evaluation of a patient with suspected BCC or in cases of recurrence. The technique is cheap, quick, less invasive, and highly accurate for the diagnosis of BCC. The limitation of the technique is low yield in some of the cases.

scholarly journals DDX5 Silencing Suppresses the Migration of Basal cell Carcinoma Cells by Downregulating JAK2/STAT3 Pathway

2019 ◽  
Vol 18 ◽  
pp. 153303381989225 ◽  
Author(s):  
Zhe Quan ◽  
Bei-bei Zhang ◽  
Fang Yin ◽  
Jiru Du ◽  
Yuan-ting Zhi ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Human Cancer ◽  
Carcinoma Cells ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Migration And Invasion ◽  
Stat3 Pathway

Basal cell carcinoma is driven by the aberrant activation of hedgehog signaling. DEAD (Asp-Glu-Ala-Asp) box protein 5 is frequently overexpressed in human cancer cells and associated with the tumor growth and invasion. The purpose of this study was to investigate the role of DEAD (Asp-Glu-Ala-Asp) box protein 5 in the growth, migration, and invasion of basal cell carcinoma. The role of DEAD (Asp-Glu-Ala-Asp) box protein 5 was detected by quantitative real-time polymerase chain reaction, Western blot, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay in basal cell carcinoma cells. The associations between JAK2/STAT3 pathway and DEAD (Asp-Glu-Ala-Asp) box protein 5 were analyzed in basal cell carcinoma cells. Results showed that DEAD (Asp-Glu-Ala-Asp) box protein 5 is overexpressed in basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown inhibited the migration and invasion of basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased the apoptosis of basal cell carcinoma cells induced by tunicamycin. Results found that DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased JAK2 and STAT3 expression in basal cell carcinoma cells. JAK2 inhibitor decreased STAT3 expression and abolished the inhibitory effects of DEAD (Asp-Glu-Ala-Asp) box protein 5 silencing on migration and invasion in basal cell carcinoma cells. In conclusion, these results indicate that DEAD (Asp-Glu-Ala-Asp) box protein 5 is a potential target for inhibiting basal cell carcinoma cells growth, migration, and invasion by downregulating JAK2/STAT3 pathway.

Role of adhesion molecules in basal cell carcinoma

1993 ◽  
Vol 3 ◽  
pp. 46
Author(s):  
M. E. Verhaegh ◽  
J. C. Veraart ◽  
R. -F. Hulsmans ◽  
J. -W. Arends ◽  
M. H. Neumann
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Adhesion Molecules ◽  
Basal Cell

Geographic Pathology of Skin Cancer

1999 ◽  
Vol 3 (3) ◽  
pp. 120-122
Author(s):  
Robert Jackson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Sun Exposure

Background: The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. Objective: This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. Conclusion: Urbach showed that the areas of greatest sun exposure on his manikins corresponded with the location of 95% of squamous cell carcinoma and 66% of basal cell carcinoma. He also clearly showed the importance of scattered sky and reflected radiation.

scholarly journals Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

BIOCELL ◽  
2021 ◽  
Vol 45 (6) ◽  
pp. 1543-1550
Author(s):  
MAJA MILOSEVIC ◽  
MILOS LAZAREVIC ◽  
BOSKO TOLJIC ◽  
MILAN PETROVIC ◽  
MIROSLAV VUKADINOVIC ◽  
...  
Keyword(s):  
Stem Cells ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Chondrogenic Differentiation ◽  
Differentiation Potential
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