Sometimes, the evacuation measure may seem to be the best choice as an emergency response. To enable an efficiency evacuation, a network optimization model which integrates lane-based reversal design and routing with intersection crossing conflict elimination for evacuation is constructed. The proposed bilevel model minimizes the total evacuation time to leave the evacuation zone. A tabu search algorithm is applied to find an optimal lane reversal plan in the upper-level. The lower-level utilizes a simulated annealing algorithm to get two types of “a single arc for an intersection approach” and “multiple arcs for an intersection approach” lane-based route plans with intersection crossing conflict elimination. An experiment of a nine-intersection evacuation zone illustrates the validity of the model and the algorithm. A field case with network topology of Jianye District around the Nanjing Olympics Sports Center is studied to show the applicability of this algorithm.