Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab

2009 ◽  
Vol 158 (2) ◽  
pp. 294-301 ◽  
Author(s):  
James L. Hare ◽  
Joseph K. Brown ◽  
Rodel Leano ◽  
Carly Jenkins ◽  
Natasha Woodward ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Myocardial Dysfunction ◽  
Breast Cancer Treatment ◽  
Myocardial Deformation ◽  
Deformation Imaging ◽  
Myocardial Deformation Imaging

Abstract 2294: The Use of Myocardial Deformation Imaging Based on Ultrasonic Pixel Tracking to Identify Reversible Myocardial Dysfunction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Michael Becker ◽  
Mithra Lenzen ◽  
Katharina Stempel ◽  
Andreas Franke ◽  
Malte Kelm ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Myocardial Viability ◽  
Predictive Value ◽  
Ventricular Dysfunction ◽  
Myocardial Dysfunction ◽  
Radial Strain ◽  
Left Ventricular ◽  
Myocardial Deformation ◽  
Deformation Imaging ◽  
Myocardial Deformation Imaging

Objective. Myocardial deformation imaging allows analysis of myocardial Objective. Myocardial deformation imaging allows analysis of myocardial viability in ischemic left ventricular dysfunction. This study evaluated the predictive value of myocardial deformation imaging for improvement in cardiac function after revascularization therapy in comparison to contrast-enhanced cardiac magnetic resonance imaging (ceMRI). Methods and Results. In 53 patients with ischemic left ventricular dysfunction, myocardial viability was assessed using pixel-tracking-derived myocardial deformation imaging and ceMRI to predict recovery of function at 9±2 months follow-up. For each left ventricular segment in a 16-segment model peak systolic radial strain was determined from parasternal 2D echocardiographic views using an automatic frame-by-frame tracking system of natural acoustic echocardiographic markers (EchoPAC, GE Ultrasound), and maximal thickness of myocardial tissue without late enhancement (LE) using ceMRI. Of 463 segments with abnormal baseline function, 227 showed regional recovery. Compared with segments showing functional improvement, those that failed to recover had lower radial strain (15.2±7.5 vs 22.6±6.3 %; p<0.001) and lower thickness without LE (5.2±2.9 vs 8.7±2.2 mm; p<0.001). Using a cut-off of 17.2 % for peak systolic radial strain, functional recovery could be predicted with high accuracy (specificity 85%, sensitivity 70%, area under the curve (AUC) 0.859, 95% CI: 0.825– 0.893). The predictive value of thickness without LE by ceMRI was similar at a cut-off of 8.2 mm (specificity 84%, sensitivity 70%, AUC 0.831, 95% CI: 0.793– 0.870). Conclusion. Myocardial deformation imaging based on frame-to-frame tracking of acoustic markers in 2D echocardiographic images is a powerful novel modality to identify reversible myocardial dysfunction.

scholarly journals Myocardial Deformation Imaging Based on Ultrasonic Pixel Tracking to Identify Reversible Myocardial Dysfunction

2008 ◽  
Vol 51 (15) ◽  
pp. 1473-1481 ◽  
Author(s):  
Michael Becker ◽  
Alexandra Lenzen ◽  
Christina Ocklenburg ◽  
Katharina Stempel ◽  
Harald Kühl ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Myocardial Deformation ◽  
Deformation Imaging ◽  
Myocardial Deformation Imaging
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