The relaxant effect of nifedipine in human uterine smooth muscle and the BKCa channel

2008 ◽  
Vol 198 (2) ◽  
pp. 237.e1-237.e8 ◽  
Author(s):  
Audrey T. Moynihan ◽  
Terry J. Smith ◽  
John J. Morrison
1998 ◽  
Vol 30 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Mercedes Gutiérrez ◽  
Ana I. Fernández ◽  
M.Pilar Revuelta ◽  
Begoña Cantabrana ◽  
Agustin Hidalgo

2019 ◽  
Vol 14 (4) ◽  
pp. 429-433 ◽  
Author(s):  
Dong Joon Kim ◽  
Mi Ha Hwang ◽  
Tae Hun An ◽  
Ki Tae Jung

1996 ◽  
Vol 48 (11) ◽  
pp. 1169-1173 ◽  
Author(s):  
C. PEREZ-GUERRERO ◽  
M. D. HERRERA ◽  
E. MARHUENDA

1997 ◽  
Vol 52 (9-10) ◽  
pp. 687-693 ◽  
Author(s):  
M. Alvarez de Sotomayor ◽  
M. D. Herrera ◽  
C. Perez-Guerrero ◽  
E. Marhuenda

Zolpidem is an imidazopyridine sedative-hypnotic which interacts with central benzodiazepine- receptors. To examine its effects on uterine smooth muscle we have compared with those obtained by diltiazem, papaverine and diazepam on different experimental models. The IC50 values obtained indicate similar behaviour of zolpidem and diazepam. They showed more active against the spontaneous contractions and those induced by KCl (60 mᴍ) or by CaCl2 (0.01-10 mᴍ) in Ca2+-free depolarizing medium than against acetylcholine (0.1 mᴍ)-induced contractions. Both of them also showed more effectiveness against the tonic component of the acetylcholine-evoked contraction than against the phasic one. All the drugs tested were less powerful against contractions induced by oxytocin than against those induced by other agonists. This observation let us speculate that the mechanism of action of zolpidem may be related to an action on Ca2+ influx through voltage-dependent Ca2+ channels due to an interaction with low affinity receptor located at the plasmalemma as has been suggested for diazepam


2021 ◽  
pp. 106689692199779
Author(s):  
Murat Celik

Leiomyoma is a benign mesenchymal tumor that develops from smooth muscle cells. It can present in various histological variants. Leiomyoma with bizarre nuclei is an infrequent variant of uterine smooth muscle neoplasm. It is characterized by focally or diffusely distributed bizarre cells on the background of a typical leiomyoma. These bizarre cells are large, multinucleated, or multilobulated and have an eosinophilic cytoplasm. Even though leiomyomas with bizarre nuclei display benign clinical behavior, their differential diagnosis from leiomyosarcoma can sometimes be difficult. Leiomyoma has been described most commonly in the uterus. There is no case of leiomyoma originating from paratubal cysts described in the literature. In this article, we present a rare case of leiomyoma with bizarre nuclei originating from a paratubal cyst.


1981 ◽  
Vol 256 (11) ◽  
pp. 5436-5442
Author(s):  
J.F. Krall ◽  
S.C. Leshon ◽  
M. Frolich ◽  
S.G. Korenman

1995 ◽  
Vol 27 (5) ◽  
pp. 407-414 ◽  
Author(s):  
B. STIEMER ◽  
R. GRAF ◽  
H. NEUDECK ◽  
R. HILDEBRANDT ◽  
H. HOPP ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document