370: Timing of arrested fetal brain growth in congenital heart disease (CHD)

2012 ◽  
Vol 206 (1) ◽  
pp. S173
Author(s):  
Ozhan M. Turan ◽  
Sifa Turan ◽  
Julia Dovgun ◽  
Ulrich Gembruch ◽  
Chris Harman ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Brain Growth

379: Patterns of compromised fetal brain growth in congenital heart disease (CHD)

2012 ◽  
Vol 206 (1) ◽  
pp. S176-S177 ◽  
Author(s):  
Sifa Turan ◽  
Ozhan Turan ◽  
Mostafa Hussein ◽  
Ulrich Gembruch ◽  
Chris Harman ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Brain Growth

Abstract 16738: Association Between First and Second Trimester Maternal Screening Biochemistry, Ultrasound, and Fetal Brain Growth in Presence of Fetal or Maternal Congenital Heart Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Aman Sharma ◽  
Emma Lewis ◽  
Gabrielle Gray ◽  
Jennifer R Maldonado ◽  
Diana L Knoedel ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Nuchal Translucency ◽  
Second Trimester ◽  
Fetal Head ◽  
Placental Dysfunction ◽  
Z Scores ◽  
Hormonal Levels

Introduction: Newer research has highlighted significant neurological impairments in children and adults with congenital heart disease (CHD). The more severe the heart defect, the higher the neurologic impairment. Pregnancies complicated by fetal or maternal CHD carry a higher risk of placental abnormalities. We studied the association between pregnancy hormonal levels and fetal head and body growth. Hypothesis: Placental dysfunction in pregnancies with fetal or maternal CHD alters pregnancy hormonal levels affecting fetal brain and somatic growth. Methods: We performed a retrospective case-control study on pregnant women (year 2010-2019) at the University of Iowa. Only women with first and/or second trimester prenatal screening (ultrasound and blood test) were included. Pregnancies with fetal chromosomal abnormalities, multiple gestation, maternal diabetes, smoking, or hypertension were excluded. Pregnancies were either healthy controls (n=36), women with CHD (MCHD; n=26), or fetus with CHD (FCHD; n=23). Pregnancy hormonal levels, ultrasound findings, and fetal/neonatal growth percentiles and/or z-scores data were analyzed. Results: Women with CHD were younger (p=0.004) with increased fetal nuchal translucency (p=0.003) compared to controls. Women in MCHD (p=0.02) and FCHD (p=0.02) group delivered earlier than controls. FCHD had significantly lower pregnancy associated plasma protein-A (PAPP-A) levels than controls (p=0.04). The groups had no difference in the second trimester fetal head circumference (HC) and femur length. FCHD group had significantly smaller HC percentile (p=0.03) and z-scores (p=0.03) at birth than controls. Both FCHD and MCHD had smaller birth weight and length compared to controls. However, only FCHD group demonstrated significantly lower HC to birth weight ratio (p=0.01). The controls had a positive correlation between human chorionic gonadotropin level and head circumference z-score at birth (r=0.34;p=0.053). Conclusions: Pregnant women with CHD have increased fetal nuchal translucency and deliver at earlier gestational age. Women with fetal CHD have smaller neonatal head and body size at birth with associated low PAPP-A level early in their pregnancy probably related to placental dysfunction.

Abstract 17204: Asymmetric Patterns of Cerebral Cortical Development in Fetuses With Complex Congenital Heart Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Yuanchiao Lu ◽  
Kushal Kapse ◽  
Nicole Andersen ◽  
Catherine Lopez ◽  
Jessica Quistorff ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Fetal Mri ◽  
Complex Congenital Heart Disease ◽  
Single Shot ◽  
Healthy Controls ◽  
Hemispheric Asymmetries ◽  
The Right

Introduction: Neurodevelopmental disabilities are common among infants with complex congenital heart disease (CHD). While hemispheric asymmetries in normal fetal brain size and shape have been reported, the effect of CHD on hemispheric development of the developing fetal brain remains unknown. Hypothesis: We hypothesized that emerging cerebral hemispheric asymmetries of the fetal CHD brain would differ compared to healthy controls using in vivo MRI tools. Methods: A total of 252 pregnant women were recruited (164 controls; 88 CHD fetuses), in which 328 fetal MRI scans were performed. Single shot fast spin echo T2-weighted images were acquired on a 1.5T GE MRI scanner. High-resolution 3D models of the fetal brain were reconstructed using slice-to-volume registration method for motion correction and Draw-EM algorithm for automatic segmentation. Volumetric analysis of brain tissues was conducted, and cortical folding measures of brain lobes were evaluated. Mixed effects regression was utilized to compare the brain features between right and left hemispheres for healthy controls and CHD fetuses. Results: The mean gestational age of all fetal MRI studies was 32.1±3.7 weeks (range: 24.0-39.4). For healthy fetuses, the volume of cortical gray matter was higher in the left hemisphere; however, this pattern was diminished in CHD fetuses. Gyrification indices were higher in the parietal and occipital lobes of the right hemisphere for controls, but not for CHD fetuses. Similarly, Gaussian curvature was higher in the right frontal lobe for controls only. Conversely, the surface area of the left occipital lobe was lower in CHD fetuses, but not in healthy fetuses. Conclusions: We report for the first time early disturbances in emerging hemispheric asymmetric patterns of the fetal brain in CHD compared to controls. The extent to which these lateralization differences reflect genetic, epigenetic and/or hemodynamic disturbances in CHD fetuses is under investigation.

scholarly journals Congenital Heart Disease Affects Cerebral Size but Not Brain Growth

2012 ◽  
Vol 33 (7) ◽  
pp. 1138-1146 ◽  
Author(s):  
Cynthia Ortinau ◽  
Terrie Inder ◽  
Jennifer Lambeth ◽  
Michael Wallendorf ◽  
Kirsten Finucane ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Brain Growth

scholarly journals Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease

2018 ◽  
Vol 29 (8) ◽  
pp. 3605-3616 ◽  
Author(s):  
Cynthia M Ortinau ◽  
Caitlin K Rollins ◽  
Ali Gholipour ◽  
Hyuk Jin Yun ◽  
Mackenzie Marshall ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Similarity Index ◽  
Fetal Brain ◽  
Brain Magnetic Resonance Imaging ◽  
Pattern Similarity ◽  
Gyrification Index ◽  
Magnetic Resonance Imaging Mri ◽  
Sulcal Pattern

Abstract Fetuses with congenital heart disease (CHD) have third trimester alterations in cortical development on brain magnetic resonance imaging (MRI). However, the intersulcal relationships contributing to global sulcal pattern remain unknown. This study applied a novel method for examining the geometric and topological relationships between sulci to fetal brain MRIs from 21–30 gestational weeks in CHD fetuses (n = 19) and typically developing (TD) fetuses (n = 17). Sulcal pattern similarity index (SI) to template fetal brain MRIs was determined for the position, area, and depth for corresponding sulcal basins and intersulcal relationships for each subject. CHD fetuses demonstrated altered global sulcal patterns in the left hemisphere compared with TD fetuses (TD [SI, mean ± SD]: 0.822 ± 0.023, CHD: 0.795 ± 0.030, P = 0.002). These differences were present in the earliest emerging sulci and were driven by differences in the position of corresponding sulcal basins (TD: 0.897 ± 0.024, CHD: 0.878 ± 0.019, P = 0.006) and intersulcal relationships (TD: 0.876 ± 0.031, CHD: 0.857 ± 0.018, P = 0.033). No differences in cortical gyrification index, mean curvature, or surface area were present. These data suggest our methods may be more sensitive than traditional measures for evaluating cortical developmental alterations early in gestation.

scholarly journals Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease

2020 ◽  
Vol 89 (1) ◽  
pp. 143-157
Author(s):  
Caitlin K. Rollins ◽  
Cynthia M. Ortinau ◽  
Christian Stopp ◽  
Kevin G. Friedman ◽  
Wayne Tworetzky ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Growth Trajectories ◽  
Brain Growth ◽  
Regional Brain

scholarly journals Association of Isolated Congenital Heart Disease with Fetal Brain Maturation

2020 ◽  
Vol 41 (8) ◽  
pp. 1525-1531 ◽  
Author(s):  
C. Jaimes ◽  
V. Rofeberg ◽  
C. Stopp ◽  
C.M. Ortinau ◽  
A. Gholipour ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Brain ◽  
Brain Maturation

Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth

2018 ◽  
Vol 38 (13) ◽  
pp. 1042-1048 ◽  
Author(s):  
Vidya Rajagopalan ◽  
Jodie K. Votava‐Smith ◽  
Xiaowei Zhuang ◽  
Jessica Brian ◽  
Lila Marshall ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Brain Growth ◽  
Regional Brain
Sign in / Sign up

Export Citation Format

Share Document