scholarly journals 923: Avoiding trade-offs: Clinical experience for noninvasive prenatal screen with low no-call rate and high accuracy

2019 ◽  
Vol 220 (1) ◽  
pp. S596-S597
Author(s):  
Susan E. Hancock ◽  
Rotem Ben-Shachar ◽  
Christa Adusei ◽  
Carrie Haverty ◽  
Dale Muzzey
2019 ◽  
Vol 133 (1) ◽  
pp. 116S-117S
Author(s):  
Susan Hancock ◽  
Rotem Ben-Shachar ◽  
Christa Adusei ◽  
Carrie Haverty ◽  
Jim Goldberg

2020 ◽  
Vol 8 ◽  
pp. 695-709
Author(s):  
Matthias Sperber ◽  
Hendra Setiawan ◽  
Christian Gollan ◽  
Udhyakumar Nallasamy ◽  
Matthias Paulik

The conventional paradigm in speech translation starts with a speech recognition step to generate transcripts, followed by a translation step with the automatic transcripts as input. To address various shortcomings of this paradigm, recent work explores end-to-end trainable direct models that translate without transcribing. However, transcripts can be an indispensable output in practical applications, which often display transcripts alongside the translations to users. We make this common requirement explicit and explore the task of jointly transcribing and translating speech. Although high accuracy of transcript and translation are crucial, even highly accurate systems can suffer from inconsistencies between both outputs that degrade the user experience. We introduce a methodology to evaluate consistency and compare several modeling approaches, including the traditional cascaded approach and end-to-end models. We find that direct models are poorly suited to the joint transcription/translation task, but that end-to-end models that feature a coupled inference procedure are able to achieve strong consistency. We further introduce simple techniques for directly optimizing for consistency, and analyze the resulting trade-offs between consistency, transcription accuracy, and translation accuracy. 1


Author(s):  
M. Nishigaki ◽  
S. Katagiri ◽  
H. Kimura ◽  
B. Tadano

The high voltage electron microscope has many advantageous features in comparison with the ordinary electron microscope. They are a higher penetrating efficiency of the electron, low chromatic aberration, high accuracy of the selected area diffraction and so on. Thus, the high voltage electron microscope becomes an indispensable instrument for the metallurgical, polymer and biological specimen studies. The application of the instrument involves today not only basic research but routine survey in the various fields. Particularly for the latter purpose, the performance, maintenance and reliability of the microscope should be same as those of commercial ones. The authors completed a 500 kV electron microscope in 1964 and a 1,000 kV one in 1966 taking these points into consideration. The construction of our 1,000 kV electron microscope is described below.


2000 ◽  
Vol 64 (6) ◽  
pp. 440-444
Author(s):  
PC Lekic ◽  
RJ Schroth ◽  
O Odlum ◽  
J deVries ◽  
D Singer

2015 ◽  
Vol 58 ◽  
pp. 83-100 ◽  
Author(s):  
Selena Gimenez-Ibanez ◽  
Marta Boter ◽  
Roberto Solano

Jasmonates (JAs) are essential signalling molecules that co-ordinate the plant response to biotic and abiotic challenges, as well as co-ordinating several developmental processes. Huge progress has been made over the last decade in understanding the components and mechanisms that govern JA perception and signalling. The bioactive form of the hormone, (+)-7-iso-jasmonyl-l-isoleucine (JA-Ile), is perceived by the COI1–JAZ co-receptor complex. JASMONATE ZIM DOMAIN (JAZ) proteins also act as direct repressors of transcriptional activators such as MYC2. In the emerging picture of JA-Ile perception and signalling, COI1 operates as an E3 ubiquitin ligase that upon binding of JA-Ile targets JAZ repressors for degradation by the 26S proteasome, thereby derepressing transcription factors such as MYC2, which in turn activate JA-Ile-dependent transcriptional reprogramming. It is noteworthy that MYCs and different spliced variants of the JAZ proteins are involved in a negative regulatory feedback loop, which suggests a model that rapidly turns the transcriptional JA-Ile responses on and off and thereby avoids a detrimental overactivation of the pathway. This chapter highlights the most recent advances in our understanding of JA-Ile signalling, focusing on the latest repertoire of new targets of JAZ proteins to control different sets of JA-Ile-mediated responses, novel mechanisms of negative regulation of JA-Ile signalling, and hormonal cross-talk at the molecular level that ultimately determines plant adaptability and survival.


1962 ◽  
Vol 42 (6) ◽  
pp. 691-705 ◽  
Author(s):  
Arnold L. Flick ◽  
Karl F. Voegtlin ◽  
Cyrus E. Rubin

2005 ◽  
Vol 173 (4S) ◽  
pp. 413-413 ◽  
Author(s):  
Ajay Gupta ◽  
Mohamad E. Allaf ◽  
Christopher A. Warlick ◽  
Thomas W. Jarrett ◽  
David Y. Chan ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 379-380
Author(s):  
James E. Kennedy ◽  
Rowland O. Illing ◽  
Feng Wu ◽  
Gail R. ter Haar ◽  
Rachel R. Phillips ◽  
...  

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