Spontaneous preterm birth and PPROM After Fetoscopic laser Surgery for TTTS- Systematic review and Meta-analysis

IntroductionPreterm birth (PTB) is the leading cause of neonatal mortality and short- and long-term morbidity. The aetiology and pathophysiology of spontaneous PTB (sPTB) are still unclear, which makes the identification of reliable and accurate predictor markers more difficult, particularly for unscreened or asymptomatic women. Metabolomics biomarkers have been demonstrated to be potentially accurate biomarkers for many disorders with complex mechanisms such as PTB. Therefore, we aim to perform a systematic review of metabolomics markers associated with sPTB. Our research question is ‘What is the performance of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women?’Methods and analysisWe will focus on studies assessing metabolomics techniques for predicting sPTB in asymptomatic pregnant women. We will conduct a comprehensive systematic review of the literature from the last 10 years. Only observational cohort and case-control studies will be included. Our search strategy will be carried out by two independent reviewers, who will scan title and abstract before carrying out a full review of the article. The scientific databases to be explored include PubMed, MedLine, ScieLo, EMBASE, LILACS, Web of Science, Scopus and others.Ethics and disseminationThis systematic review protocol does not require ethical approval. We intend to disseminate our findings in scientific peer-reviewed journal, the Preterm SAMBA study open access website, specialists’ conferences and to our funding agencies.PROSPERO registration numberCRD42018100172.

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Faculty Opinions recommendation of Antiplatelet Agents and the Prevention of Spontaneous Preterm Birth: A Systematic Review and Meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727200934.793534019 ◽

2017 ◽

Author(s):

Jeff Keelan

Keyword(s):

Systematic Review ◽

Preterm Birth ◽

Meta Analysis ◽

Antiplatelet Agents ◽

Spontaneous Preterm Birth

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Letter to the Editor: Fetal growth and spontaneous preterm birth in high‐altitude pregnancy: A systematic review, meta‐analysis, and meta‐regression

International Journal of Gynecology & Obstetrics ◽

10.1002/ijgo.13977 ◽

2021 ◽

Author(s):

Lin Yang ◽

Thomas Waldhoer

Keyword(s):

Systematic Review ◽

Preterm Birth ◽

High Altitude ◽

Fetal Growth ◽

Meta Analysis ◽

Spontaneous Preterm Birth ◽

Letter To The Editor ◽

Meta Regression

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The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

Fetal Diagnosis and Therapy ◽

10.1159/000510648 ◽

2021 ◽

pp. 1-7

Author(s):

Kamran Hessami ◽

Maryam Kasraeian ◽

Álvaro Sepúlveda-Martínez ◽

Mauro Cristian Parra-Cordero ◽

Homeira Vafaei ◽

...

Keyword(s):

Systematic Review ◽

Preterm Birth ◽

Meta Analysis ◽

Predictive Marker ◽

Second Trimester ◽

Spontaneous Preterm Birth ◽

Increased Risk ◽

Study Heterogeneity ◽

Mean Differences ◽

Twin Pregnancies

The alteration of the uterocervical angle (UCA) has been proposed to play an important role in spontaneous preterm birth (sPTB). The aim of this systematic review and meta-analysis was to evaluate the evidence on the UCA predictive role in sPTB. In this study, PubMed, Web of Science, Scopus, and Google scholar were systematically searched from inception up to June 2020. Inter-study heterogeneity was also assessed using Cochrane’s Q test and the I2 statistic. Afterward, the random-effects model was used to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Eleven articles that reported second-trimester UCA of 5,061 pregnancies were included in this study. Our meta-analysis results indicate that a wider UCA significantly increases the risk of sPTB in following cases: all pregnancies (WMD = 15.25, 95% CI: 11.78–18.72, p < 0.001; I2 = 75.9%, p < 0.001), singleton (WMD = 14.43, 95% CI: 8.79–20.06, p < 0.001; I2 = 82.4%, p < 0.001), and twin pregnancies (WMD = 15.14, 95% CI: 13.42–16.87, p < 0.001; I2 = 0.0%, p = 0.464). A wider ultrasound-measured UCA in the second trimester seems to be associated with the increased risk of sPTB in both singleton and twin pregnancies, which reinforces the clinical evidence that UCA has the potential to be used as a predictive marker of sPTB.

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