scholarly journals MicroRNA 96 Is a Post-Transcriptional Suppressor of Anaplastic Lymphoma Kinase Expression

2012 ◽  
Vol 180 (5) ◽  
pp. 1772-1780 ◽  
Author(s):  
Deeksha Vishwamitra ◽  
Yong Li ◽  
Desiree Wilson ◽  
Roxsan Manshouri ◽  
Choladda V. Curry ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Anaplastic Lymphoma ◽  
Kinase Expression ◽  
Transcriptional Suppressor

Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma

2013 ◽  
Vol 66 (8) ◽  
pp. 705-707 ◽  
Author(s):  
Harumi Nakamura ◽  
Koji Tsuta ◽  
Akihiko Yoshida ◽  
Tatsuhiro Shibata ◽  
Susumu Wakai ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Anaplastic Lymphoma Kinase ◽  
High Grade ◽  
Anaplastic Lymphoma ◽  
Kinase Expression

Anaplastic lymphoma kinase expression and gene alterations in glioblastoma: correlations with clinical outcome

2016 ◽  
Vol 70 (7) ◽  
pp. 593-599 ◽  
Author(s):  
George Karagkounis ◽  
George Stranjalis ◽  
Theodore Argyrakos ◽  
Varvara Pantelaion ◽  
Konstantinos Mastoris ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Anaplastic Lymphoma Kinase ◽  
In Situ Hybridisation ◽  
Proliferation Index ◽  
Isocitrate Dehydrogenase 1 ◽  
Anaplastic Lymphoma ◽  
Alk Positive ◽  
Mutant Idh1 ◽  
Kinase Expression ◽  
Gene Alterations

AimsTo study anaplastic lymphoma kinase (ALK) protein expression and possible underlying gene alterations in glioblastoma (GBM), correlating them with clinical outcome.MethodsWe studied ALK immunohistochemical expression and fluorescent in situ hybridisation (FISH)-detected ALK gene alterations in 51 GBMs (46 isocitrate dehydrogenase-1 (IDH1)R132H-negative and 5 IDH-mutant (IDH1R132H-positive)). We compared two anti-ALK antibodies and immunohistochemical detection systems (5Α4/Nichirei Biosciences, D5F3/Ventana). The results were correlated with tumour cell proliferation and clinical outcome.ResultsIntense granular cytoplasmic ALK immunostaining was observed in 10/51 (19.61%) GBM and correlated with high Ki67 proliferation index; only 1 in 10 ALK-positive cases displayed multiple alk gene signals by FISH. Moderate ALK immunostaining was observed in 21 (41.17%), weak immunostaining in 5 (9.80%) while 15 (29.42%) cases were negative. p53 was expressed in 26/51 GBM (50.9%) (10% cut-off). IDH1R132H-negative GBM showed higher ALK expression compared with IDH-mutant GBM (65.2% vs 20%). ALK overexpression was more common in older patients but did not correlate with other clinicopathological variables or patient overall survival.ConclusionsALK overexpression can be identified in up to 70% of GBMs and does not correlate with underlying alk gene amplification. Despite being more common in rapidly growing, clinically aggressive GBM, ALK overexpression did not show correlation with prognosis in this study.

ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction

2009 ◽  
Vol 29 (2) ◽  
pp. 275-286 ◽  
Author(s):  
Joffrey Degoutin ◽  
Nicole Brunet-de Carvalho ◽  
Carmen Cifuentes-Diaz ◽  
Marc Vigny
Keyword(s):  
Schwann Cells ◽  
Anaplastic Lymphoma Kinase ◽  
Drg Neurons ◽  
Anaplastic Lymphoma ◽  
Kinase Expression

scholarly journals Prognostic Value of Tumor Stem Cells and Anaplastic Lymphoma Kinase Expression in Patients with Primary Cutaneous Melanoma

2019 ◽  
Vol 7 (3) ◽  
pp. 62
Author(s):  
Titov Konstantin Sergeevich ◽  
Kazakov Alexey Mikhailovich ◽  
Baryshnikova Maria Anatolievna ◽  
Zaryanov Dmitry Albertovich ◽  
Ryabchikov Denis Anatolyevich
Keyword(s):  
Stem Cells ◽  
Cutaneous Melanoma ◽  
Anaplastic Lymphoma Kinase ◽  
Prognostic Value ◽  
Tumor Stem Cells ◽  
Primary Cutaneous Melanoma ◽  
Anaplastic Lymphoma ◽  
Kinase Expression

Anaplastic lymphoma kinase expression in small‐cell lung cancer

2019 ◽  
Vol 75 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Chiaki Kondoh ◽  
Yoshitsugu Horio ◽  
Yuko Hayashi ◽  
Hiromichi Ebi ◽  
Toyoaki Hida ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Anaplastic Lymphoma Kinase ◽  
Small Cell ◽  
Small Cell Lung ◽  
Anaplastic Lymphoma ◽  
Kinase Expression

scholarly journals Comment on “ALK is a therapeutic target for lethal sepsis”

2018 ◽  
Vol 10 (471) ◽  
pp. eaar4321 ◽  
Author(s):  
Rafael B. Blasco ◽  
Enrico Patrucco ◽  
Ines Mota ◽  
Wei-Tien Tai ◽  
Roberto Chiarle
Keyword(s):  
Bioactive Compounds ◽  
Anaplastic Lymphoma Kinase ◽  
Therapeutic Target ◽  
Anaplastic Lymphoma ◽  
Lethal Sepsis ◽  
Monocytes And Macrophages ◽  
Kinase Expression ◽  
Human And Mouse

Physiologically relevant ALK (anaplastic lymphoma kinase) expression was not detected in human and mouse monocytes and macrophages, suggesting that the effects of bioactive compounds on stimulator of interferon genes (STING) activation may not depend on ALK.

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