scholarly journals The Paradoxical Web of Pancreatic Cancer Tumor Microenvironment

2019 ◽  
Vol 189 (1) ◽  
pp. 44-57 ◽  
Author(s):  
Kelly J. Lafaro ◽  
Laleh G. Melstrom
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Cancer Tumor

Role of Tumor Microenvironment on Gene Expression in Pancreatic Cancer Tumor Models

2011 ◽  
Vol 171 (1) ◽  
pp. 136-142 ◽  
Author(s):  
Soeren Torge Mees ◽  
Wolf Arif Mardin ◽  
Christina Schleicher ◽  
Mario Colombo-Benkmann ◽  
Norbert Senninger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Tumor Models ◽  
Cancer Tumor

Abstract 437: Longitudinal imaging of the pancreatic cancer tumor microenvironment

2011 ◽  
Author(s):  
Masashi Momiyama ◽  
Atsushi Suetsugu ◽  
Yasunori Tome ◽  
Michael Bouvet ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Cancer Tumor ◽  
Longitudinal Imaging

scholarly journals Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

2014 ◽  
Vol 3 (11) ◽  
pp. e962401 ◽  
Author(s):  
Eric R Lutz ◽  
Heather Kinkead ◽  
Elizabeth M Jaffee ◽  
Lei Zheng
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Checkpoint Inhibitor ◽  
Cancer Tumor

scholarly journals Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 329
Author(s):  
Patrick W. Underwood ◽  
Dong Yu Zhang ◽  
Miles E. Cameron ◽  
Michael H. Gerber ◽  
Daniel Delitto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Cancer Patient ◽  
Xenograft Model ◽  
Pancreatic Cancer Patient ◽  
Nicotine Treatment ◽  
Pancreatic Cancer Cells ◽  
Cancer Tumor

Smoking is highly associated with pancreatic cancer. Nicotine, the addictive component of tobacco, is involved in pancreatic cancer tumorigenesis, metastasis, and chemoresistance. This work aimed to describe the role of nicotine within the pancreatic cancer tumor microenvironment. Nicotine treatment was used in vitro to assess its effect on tumor-associated stromal cells and pancreatic cancer cells. Nicotine treatment was then used in a pancreatic cancer patient-derived xenograft model to study the effects in vivo. Nicotine induced secretion of interleukin 8 (IL-8) by tumor-associated stroma cells in an extracellular signal-regulated kinase (ERK)-dependent fashion. The secreted IL-8 and nicotine acted on the pancreatic cancer cell, resulting in upregulation of IL-8 receptor. Nicotine treatment of mice bearing pancreatic cancer patient-derived xenografts had significantly increased tumor mass, increased tumor-free weight loss, and decreased muscle mass. These represent important pathways through which nicotine acts within the tumor microenvironment and worsens pancreatic cancer-induced cachexia, potentially representing future therapeutic targets.

scholarly journals Abstract 2644: Oncostatin M in pancreatic cancer tumor microenvironment

2020 ◽  
Author(s):  
Daenique H. Jengelley ◽  
Melissa L. Fishel ◽  
Michael Ostrowski ◽  
Teresa A. Zimmers
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Oncostatin M ◽  
Cancer Tumor

Pancreatic cancer tumor analysis in CT images using patch-based multi-resolution convolutional neural network

2021 ◽  
Vol 68 ◽  
pp. 102652
Author(s):  
Vahid Asadpour ◽  
Rex A. Parker ◽  
Patrick R. Mayock ◽  
Samuel E. Sampson ◽  
Wansu Chen ◽  
...  
Keyword(s):  
Neural Network ◽  
Pancreatic Cancer ◽  
Convolutional Neural Network ◽  
Ct Images ◽  
Cancer Tumor
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