Relationship between exhaled leukotriene and 8-isoprostane levels and asthma severity, asthma control level, and asthma control test score

International guidelines indicate that the main criterion of asthma management is asthma control level. The aim of this study was to assess asthma control and its relation with age, gender, and lung function. Material and methods. A total of 106 family physicians and 13 pulmonologists and allergists took part in this study. Each doctor had selected 10–15 asthma patients and had sent invitations to them by post. On the visit day, the patients themselves filled in the Asthma Control Test. The doctors interviewed the patients and filled in a special questionnaire. Pulmonologists and allergists also assessed lung function by performing spirometry. According to the results of the Asthma Control Test, the disease control level was indicated as “totally controlled” (25 points), “well controlled” (24–20 points), and “uncontrolled” (19 points or less). Results. A total of 876 asthma patients were examined. Uncontrolled asthma was diagnosed to 56.2% of the patients, 36.5% of patients had well controlled and 7.3% totally controlled asthma. There was no significant difference in asthma control level comparing men and women. A correlation between asthma control level and age was found revealing poorer asthma control in older patients. Ninety-five percent of patients were treated with inhaled steroids; most of them had used inhaled steroids in combination with long-acting β2 agonists. It was found that lung function correlated with clinical symptoms of asthma, the demand of shortacting β2 agonists, and asthma control level. Conclusion. The study showed that uncontrolled asthma was diagnosed to more than half of the patients, despite most of them used inhaled steroids. Asthma control was worsening with the age of patients with asthma and it correlated with lung function. We suggest that periodical assessment of asthma control should help to optimize asthma management.

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Correlation Between the Asthma Control Test Score and FEV1 in Nigerians With Bronchial Asthma

CHEST Journal ◽

10.1378/chest.9803 ◽

2010 ◽

Vol 138 (4) ◽

pp. 146A

Author(s):

Obianuju B. Ozoh ◽

Olarenwaju E. Bandele ◽

Cyril Chukwu ◽

Njideka Okubadejo

Keyword(s):

Asthma Control ◽

Bronchial Asthma ◽

Test Score ◽

Control Test ◽

Asthma Control Test

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The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of Th17 Cell and Asthma Control Test Score

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-0643747 ◽

2013 ◽

Vol 6 (4) ◽

pp. 37-47 ◽

Cited By ~ 2

Author(s):

Astrid Kristina Kardani Astrid Kristina Kardani

Keyword(s):

Asthma Control ◽

House Dust ◽

House Dust Mite ◽

Th17 Cell ◽

Test Score ◽

Nigella Sativa ◽

Control Test ◽

Asthma Control Test ◽

Dust Mite

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Does vitamin D deficiency in asthma affect clinical and functional parameters? A Turkish multicenter study

Allergy and Asthma Proceedings ◽

10.2500/aap.2021.42.210056 ◽

2021 ◽

Vol 42 (5) ◽

pp. e152-e158 ◽

Cited By ~ 1

Author(s):

Nurhan Sarıoglu ◽

Arzu Didem Yalcın ◽

Fusun Sahin ◽

Sadan Soyyigit ◽

Fatma Merve Tepetam ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Asthma Control ◽

Asthma Severity ◽

Control Test ◽

Asthma Control Test ◽

Functional Parameters ◽

Control Subjects ◽

Vitamin D Levels ◽

Target Values

Background: In recent years, interest in the effects of vitamin D on human health and the immune system has increased. Objective: This study aimed to investigate the relationship of vitamin D with asthma severity, attacks, and clinical and functional parameters in adult patients with asthma who were living in different geographic regions in Turkey. Methods: A total of 384 patients with stable asthma and 87 control subjects were included. A physical examination and a pulmonary function test were performed, and routine blood analyses and vitamin D levels were evaluated. Asthma Control Test was applied. The number of exacerbations in the previous year, asthma therapy, and medication adherence were recorded. Results: In our study, vitamin D levels were below the target values in both patients with asthma (median [minimum-maximum] 16.0 ng/mL [3.5‐48 ng/ml]) and control subjects (median [minimum-maximum] 20.0 ng/mL [5.8‐58.79 ng/mL]). However, it was lower in the patients with asthma than in the control subjects (p = 0.001). There was a negative relationship between the levels of vitamin D and the severity of asthma (Kendall τ = −0.146; p < 0.001). Furthermore, the patients with severe asthma were received The Global Initiative for Asthma (GINA) step 5 treatment showed significantly lower vitamin D compared with the patients who received GINA step 4 treatment (p = 0.037). Vitamin D levels correlated with forced vital capacity (FVC), forced expiratory volume in the first second of expiration (FEV1), and peak expiratory flow (r, 0.221‐0.236; p ≤ 0.001). In addition, a positive relationship was found between Asthma Control Test and vitamin D (r = 0.229; p = 0.001). However, body mass index (BMI), asthma exacerbation, and hospitalization were inversely related to vitamin D (r, 0.198‐0.233; p = 0.001). Multivariable regression analysis revealed that FVC (p = 0.002), FEV1 (p = 0.033), and BMI (p = 0.037) were independent determinants associated with vitamin D. Conclusion: This study suggested a high prevalence of vitamin D deficiency in adults with asthma living in different geographic areas in Turkey. Vitamin D deficiency is associated with asthma severity, poor control, and lower lung function.

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Correlation between fractional exhaled nitric oxide and Asthma Control Test score and spirometry parameters in on-treatment- asthmatics in Ho Chi Minh City

Journal of Thoracic Disease ◽

10.21037/jtd.2020.04.01 ◽

2020 ◽

Vol 12 (5) ◽

pp. 2197-2209

Author(s):

Vinh Nhu Nguyen ◽

Niels H. Chavannes

Keyword(s):

Nitric Oxide ◽

Asthma Control ◽

Test Score ◽

Exhaled Nitric Oxide ◽

Ho Chi Minh City ◽

Control Test ◽

Fractional Exhaled Nitric Oxide ◽

Asthma Control Test

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Circulating fibrocytes correlate with the asthma control test score

Allergologia et Immunopathologia ◽

10.1016/j.aller.2015.09.007 ◽

2016 ◽

Vol 44 (3) ◽

pp. 191-196 ◽

Cited By ~ 2

Author(s):

H. Kobayashi ◽

M. Naito ◽

M. Masuya ◽

M. Maruyama ◽

K. Urata ◽

...

Keyword(s):

Asthma Control ◽

Test Score ◽

Control Test ◽

Asthma Control Test ◽

Circulating Fibrocytes

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Reduced medication use and improved pulmonary function with supplements containing vegetable and fruit concentrate, fish oil and probiotics in asthmatic school children: a randomised controlled trial

British Journal Of Nutrition ◽

10.1017/s0007114512004692 ◽

2012 ◽

Vol 110 (1) ◽

pp. 145-155 ◽

Cited By ~ 20

Author(s):

Shu-Chen Lee ◽

Yao-Hsu Yang ◽

Shao-Yuan Chuang ◽

Shih-Yi Huang ◽

Wen-Harn Pan

Keyword(s):

Pulmonary Function ◽

Fish Oil ◽

Asthma Control ◽

Childhood Asthma ◽

Test Score ◽

Medication Use ◽

Control Test ◽

Asthma Control Test ◽

Asthmatic Children ◽

Supplement Group

Dietary pattern changes may be one of the key factors associated with increasing asthma prevalence. Observational studies have found negative associations between fruit, vegetable and fish consumption and risk of asthma. Experimental studies have also shown that probiotics can modulate the immune system. However, each dietary component exhibits a modest effect. The objective of the present study was to investigate the joint effect of multiple beneficial dietary components on asthma. We designed a 16-week school-based double-blind placebo-controlled randomised trial. The supplement group received fruit plus vegetable concentrate, fish oil and probiotics (FVFP supplement), while the control group received placebos. A total of 192 asthmatic children aged 10–12 years were recruited from elementary schools in metropolitan Taipei. Pulmonary function, medication usage, Paediatric Asthma Quality of Life Questionnaire (PAQLQ) score and the Childhood Asthma Control Test score were evaluated at baseline, and at weeks 8 and 16. Compared with the placebo group, the supplement group showed significant improvement in pulmonary function parameters (91 v. 178 ml for forced vital capacity (FVC), 40 v. 107 ml for forced expiratory volume in 1 s (FEV1) and 1·6 v. 4·8 % for FEV1:FVC ratio; all P values < 0·01) and had a significantly reduced proportion of those using short-acting inhaled bronchodilators and inhaled corticosteroids. However, the PAQLQ score and the Childhood Asthma Control Test score were not significantly different between the two groups, possibly because the majority of the children were treated routinely. FVFP supplements reduced medication use and improved pulmonary function in asthmatic children. The present study supports an adjuvant intervention with a combination of fruit, vegetable, fish and probiotic foods.

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