scholarly journals Does vitamin D deficiency in asthma affect clinical and functional parameters? A Turkish multicenter study

2021 ◽  
Vol 42 (5) ◽  
pp. e152-e158 ◽  
Author(s):  
Nurhan Sarıoglu ◽  
Arzu Didem Yalcın ◽  
Fusun Sahin ◽  
Sadan Soyyigit ◽  
Fatma Merve Tepetam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Asthma Severity ◽  
Control Test ◽  
Asthma Control Test ◽  
Functional Parameters ◽  
Control Subjects ◽  
Vitamin D Levels ◽  
Target Values

Background: In recent years, interest in the effects of vitamin D on human health and the immune system has increased. Objective: This study aimed to investigate the relationship of vitamin D with asthma severity, attacks, and clinical and functional parameters in adult patients with asthma who were living in different geographic regions in Turkey. Methods: A total of 384 patients with stable asthma and 87 control subjects were included. A physical examination and a pulmonary function test were performed, and routine blood analyses and vitamin D levels were evaluated. Asthma Control Test was applied. The number of exacerbations in the previous year, asthma therapy, and medication adherence were recorded. Results: In our study, vitamin D levels were below the target values in both patients with asthma (median [minimum-maximum] 16.0 ng/mL [3.5‐48 ng/ml]) and control subjects (median [minimum-maximum] 20.0 ng/mL [5.8‐58.79 ng/mL]). However, it was lower in the patients with asthma than in the control subjects (p = 0.001). There was a negative relationship between the levels of vitamin D and the severity of asthma (Kendall τ = −0.146; p < 0.001). Furthermore, the patients with severe asthma were received The Global Initiative for Asthma (GINA) step 5 treatment showed significantly lower vitamin D compared with the patients who received GINA step 4 treatment (p = 0.037). Vitamin D levels correlated with forced vital capacity (FVC), forced expiratory volume in the first second of expiration (FEV1), and peak expiratory flow (r, 0.221‐0.236; p ≤ 0.001). In addition, a positive relationship was found between Asthma Control Test and vitamin D (r = 0.229; p = 0.001). However, body mass index (BMI), asthma exacerbation, and hospitalization were inversely related to vitamin D (r, 0.198‐0.233; p = 0.001). Multivariable regression analysis revealed that FVC (p = 0.002), FEV1 (p = 0.033), and BMI (p = 0.037) were independent determinants associated with vitamin D. Conclusion: This study suggested a high prevalence of vitamin D deficiency in adults with asthma living in different geographic areas in Turkey. Vitamin D deficiency is associated with asthma severity, poor control, and lower lung function.

scholarly journals Vitamin D deficiency in Jordanian children with bronchial asthma : a cross sectional study

2020 ◽  
Author(s):  
Enas Al-Zayadneh ◽  
Nedal Awad Alnawaiseh ◽  
Salma Ajarmeh ◽  
Areej Hamed Altarawneh ◽  
Eman M. Albataineh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bronchial Asthma ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Control Test ◽  
Sectional Study ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Vitamin D Levels

Abstract Background : Asthma is the most common chronic diseases that affect children and its prevalence is increasing worldwide posing a great burden on healthcare systems. A growing body of evidence suggests an association between vitamin D deficiency and asthma. The current study aimed to assess serum vitamin D level in Jordanian children with bronchial asthma and to examine the correlation between vitamin D levels and asthma severity and control. Methods: A cross sectional study was conducted in the Pediatric Chest Clinic at AlKarak Governmental Hospital South of Jordan from May 2015 to February 2016. Serum level of 25-hydroxyvitamin-D was determined for 98 Children aged 1 to 14 years and diagnosed with bronchial asthma (6-14years) or recurrent wheezing episodes(<6 years). The severity of asthma was determined based on the Global Initiative for Asthma (GINA) assessment, the Asthma Control test (ACT) and the Childhood Asthma Control Test (C-ACT). The results were considered significant if P ≤.05. Statistical analysis was performed using SPSS 21 (IBM, Armonk, NY, United States of America, 2012). Results : Vitamin D levels were deficient and insufficient in 41(41.8%) and 34(34.7%) of asthmatic children, respectively. Only 23( 23.5%) had sufficient vitamin D levels. A significant correlation was found between the severity of asthma symptoms and vitamin D deficiency (Pearson Chi-squared=.028). Conclusion : Vitamin D deficiency is highly prevalent in children with bronchial asthma in Jordanian population and correlates significantly with asthma severity. Assessment of vitamin D levels in children with bronchial asthma is required in a larger scale studies in Jordan.

scholarly journals Vitamin D deficiency in children with bronchial asthma in southern Jordan: a cross-sectional study

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097424
Author(s):  
Enas Al-Zayadneh ◽  
Nedal Awad Alnawaiseh ◽  
Salma Ajarmeh ◽  
Areej Hamed Altarawneh ◽  
Eman M Albataineh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bronchial Asthma ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Objectives To assess serum 25-hydroxycholecalciferol (25-OH vitamin D) levels in Jordanian children with bronchial asthma, and to examine correlations between 25-OH vitamin D levels and asthma severity and control. Methods A cross-sectional study was conducted at the Paediatric Chest Clinic, Al-Karak Governmental Hospital, Southern Jordan, between May 2015 and February 2016. Serum 25-hydroxyvitamin D level was determined in children aged 1–14 years diagnosed with bronchial asthma (6–14 years) or recurrent wheezing episodes (<6 years). Asthma severity was determined based on the Global Initiative for Asthma assessment, the Asthma Control Test, and the Childhood Asthma Control Test. Demographic and clinical characteristics were compared between patients with low and normal 25-OH vitamin D levels, and correlations between asthma severity and 25-OH vitamin D level were assessed. Results Out of 98 included children, 25-OH vitamin D levels were deficient and insufficient in 41 (41.8%) and 34 (34.7%) children, respectively. Only 23 (23.5%) had sufficient 25-OH vitamin D levels. A significant correlation was found between severity of asthma symptoms and 25-OH vitamin D deficiency. Conclusion 25-OH vitamin D deficiency is highly prevalent in Jordanian children with bronchial asthma and correlates significantly with asthma severity.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals The Analysis of Serum Vitamin D (25[OH]D) Level in Psoriasis Patients Comparing with Control Subjects

2020 ◽  
Vol 32 (2) ◽  
pp. 111
Author(s):  
Ade Fernandes ◽  
Muhammad Yulianto Listiawan ◽  
Evy Ervianti ◽  
Trisniartami Setyaningrum
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Serum Vitamin ◽  
Normal Serum ◽  
Serum Vitamin D ◽  
Control Subjects ◽  
Vitamin D Levels ◽  
Chemiluminescent Microparticle Immunoassay ◽  
And Control

Background: Vitamin D has been shown to have an immunomodulatory effect, and previous studies have proven that vitamin D deficiency contributed to several autoimmune diseases, including psoriasis. Purpose: The purpose of this study was to determine serum vitamin D levels in psoriasis vulgaris patients and compare them with control subjects. Methods: The research samples were sixteen adults with psoriasis vulgaris and 16 control subjects. Blood samples were taken, and the serum 25 (OH) D levels were measured using the Chemiluminescent Microparticle Immunoassay method. Result: The mean serum vitamin D in psoriasis vulgaris patients and controls were 14.36 ± 6.36 and 19.92 ± 7.59 ng/mL, respectively. No psoriasis vulgaris were observed in patients with normal 25(OH)D levels, and only 3 control subjects with normal serum 25(OH)D levels. These results were not statistically significant (p = 0.09). Conclusion: Most patients with psoriasis vulgaris were observed having vitamin D deficiency. However, the prevalence of vitamin D deficiency in the control subjects was high as well. Therefore, there were no differences in serum 25(OH)D levels between psoriasis vulgaris and control patients.

Vitamin D, ventilatory function and asthma control among bronchial asthma patients

2020 ◽  
Vol 7 (3) ◽  
pp. 74-77
Author(s):  
Mohammed H. Saiem Al-Dahr
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Direct Relationship ◽  
Ventilatory Function ◽  
Asthma Control Test ◽  
Group A ◽  
Group B ◽  
Deficiency Group

Background: Asthma is a chronic conducting airway disorder which characterized by reversible airway inflammation and obstruction. However, prevalence of some pulmonary disorders as bronchial asthma is increased with Vitamin D deficiency. Objective: The target of this study is to evaluate the association between status of vitamin D and ventilatory function & asthma control in patients with bronchial asthma in Jeddah area. Material and methods: One hundred Saudi patients with asthma of both sex; their age mean was 35.18±6.27 year were selected on referral to Internal Medicine Department, King Abdulaziz University Teaching Hospital, Saudi Arabia. Asthma was diagnosed by spirometry tests. Criteria for asthma diagnosis were in accordance with the Global Strategy for Asthma Management and Prevention (GINA 2016). Exclusion criteria included patients with renal, cardiac and liver diseases. All participants will be free to withdraw from the study at any time. Following pre-training testing, participants were enrolled in three groups according to 25-OHD levels: vitamin D deficiency group (A) 25-OHD level <20ng/ml, vitamin D deficiency group (B) 25-OHD level=20–30 ng/ml and normal vitamin D group(C) 25-OHD level >30ng/ml. Results: There was significant higher values of FVC, FEV1 and FEV1/FVC in group (C) compared to subgroup (A) and group (B) in addition to lower values of asthma control test in subgroup (C) compared to group (A) and group (B). While there was significant difference between groups. Moreover, the 25-OHD showed a strong direct relationship with FVC, FEV1, FEV1/FVC and asthma control test in the three groups (P<0.05). Conclusion: There is a close direct relationship between level of vitamin D, ventilatory function and asthma control in patients with bronchial asthma.

scholarly journals Severity of Asthma and Serum Vitamin D Levels in Asthmatic Children

2019 ◽  
pp. 1-7
Author(s):  
Nasrin Bazargan ◽  
Zeinab Nazari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Public Health Problem ◽  
Asthma Severity ◽  
Asthmatic Children ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Introduction: Vitamin D deficiency has been rediscovered as a public health problem worldwide. It has been postulated that vitamin D deficiency explains a portion of the asthma epidemic. The purpose of this study was to assess the serum vitamin D levels in children with asthma as compared with the non-asthmatic population and to investigate the association of serum vitamin D levels with the severity of asthma. Materials and Methods: We measured serum 25-hydroxyvitamin D (25-OH vitamin D) levels in 50 children with mild intermittent to moderate persistent asthma at the time of enrollment and 50 age- and sex-matched non-asthmatic children in a case-control study. The independent sample t-test, c2 test, and spearman correlation coefficient were used to analyze the data. Results: Vitamin D level was 13.6 ± 1.1 ng/ml and 19.2 ± 1.8 ng/ml in asthmatic and                       non-asthmatic individuals, respectively. The mean (±SD) levels of serum vitamin D were  statistically significant between asthmatic and non-asthmatic individuals. Females had lower          levels of vitamin D than males. Asthma severity was inversely associated with serum vitamin D level. Conclusion: Findings of the present study demonstrate the significance of vitamin D in asthma. Sufficient doses of vitamin D should be administered to pregnant mothers and the babies monitored for symptoms of wheezing or asthma during childhood. Clinical trials are needed to definitively answer questions about the role of vitamin D in asthma.

scholarly journals The Quality of Life on Asthmatic Adolescent and Its Correlation with the Severity and Control of Asthma

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Lisa Adhia Garina ◽  
Muhammad Ridho Grahadinta ◽  
Ferry Achmad Firdaus Mansoer ◽  
Intan Puspitasari
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Asthma Severity ◽  
Control Test ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Global Initiative For Asthma ◽  
Global Initiative

Asthma is considered a global health problem that, if not managed properly, can reduce the sufferers' quality of life. The purpose of the study was to evaluate the quality of life from the perspectives of asthma severity and the asthma control level. A cross-sectional study was conducted from February to June 2018 on asthmatic adolescents aged 12–14 years old in two public junior high schools in Bandung city, Indonesia. The diagnosis, history of asthma,  severity, and asthma control were established based on the National Asthma Guidelines from the Indonesian Pediatric Society, Global Initiative for Asthma (GINA), asthma control test (ACT), and ISAAC questionnaire. Statistical analysis performed using SPSS v.20 with Spearman's rho to determine the significance. The gender distribution of the 98 subjects was almost similar with slightly more girls (51%). The median age was 13±1 years with average ACT, FVC, and PAQLQ(S) total scores of 20±4, 78±16%, and 5.3±1.3, respectively. The domain scores for symptoms, activity limitations, and emotional function were 4.9±1.4, 5.0±1.3, and 5.7±1.1, respectively. There are correlations between the total  PAQLQ(S) score and asthma severity (p<0.001, r=−0.5) and the level of asthma control (p<0.001, r=0.6). In summary, the quality of life has a relationship with asthma severity and the level of asthma control. Asthma management should not only focus on medication but also ways to maintain a good quality of life. KUALITAS HIDUP REMAJA ASMA DAN HUBUNGANNYA DENGAN KEKERAPAN GEJALA DAN DERAJAT KENDALI ASMAAsma masih menjadi masalah kesehatan penting yang jika tidak ditangani baik, asma dapat menurunkan kualitas hidup anak. Tujuan penelitian ini menilai kualitas hidup dan hubungannya dengan kekerapan gejala dan derajat kendali asma. Penelitian cross-sectional ini dilaksanakan dari bulan Februari hingga Juni 2018 pada remaja asma berusia 12–14 tahun di dua SMPN di Kota Bandung, Indonesia. Diagnosis, riwayat asma, kekerapan gejala, dan derajat kendali asma berdasar atas Pedoman Nasional Asma Anak Ikatan Dokter Anak Indonesia, Global Initiative for Asthma (GINA), asthma control test (ACT), dan kuesioner dari ISAAC. Analisis statistik menggunakan SPSS v.20 dengan uji Spearman’s rho untuk menentukan signifikansi. Distribusi gender dari 98 subjek penelitian hampir sama dengan sedikit lebih banyak perempuan (51%). Usia rerata subjek 13±1 tahun dengan skor rerata ACT, FVC, PAQLQ(S) masing-masing 20±4, 78±16%, dan 5,3±1,3. Skor domain gejala, keterbatasan beraktivitas, dan fungsi emosi masing-masing 4,9±1,4; 5,0±1,3; dan 5,7±1,1. Terdapat hubungan skor total PAQLQ(S) dengan kekerapan gejala (p<0,001; r=−0,5) dan dengan derajat kendali asma (p<0,001; r=0,6). Simpulan, kualitas hidup berhubungan dengan kekerapan gejala dan derajat kendali asma. Pengelolaan asma sebaiknya tidak hanya memperhatikan pengobatan, tetapi juga menjaga kualitas hidup yang baik.

Relationship between exhaled leukotriene and 8-isoprostane levels and asthma severity, asthma control level, and asthma control test score

2014 ◽  
Vol 42 (3) ◽  
pp. 191-197 ◽  
Author(s):  
O. Keskin ◽  
S. Balaban ◽  
M. Keskin ◽  
E. Kucukosmanoglu ◽  
B. Gogebakan ◽  
...  
Keyword(s):  
Asthma Control ◽  
Test Score ◽  
Control Level ◽  
Asthma Severity ◽  
Control Test ◽  
Asthma Control Test
Sign in / Sign up

Export Citation Format

Share Document