Is Late Luminal Loss an Accurate Predictor of the Clinical Effectiveness of Drug-Eluting Stents in the Coronary Arteries?

2006 ◽  
Vol 97 (5) ◽  
pp. 603-605 ◽  
Author(s):  
Pierfrancesco Agostoni ◽  
Marco Valgimigli ◽  
Antonio Abbate ◽  
John Cosgrave ◽  
Mara Pilati ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Clinical Effectiveness ◽  
Drug Eluting Stents ◽  
Accurate Predictor ◽  
Drug Eluting ◽  
Late Luminal Loss

A Fatal Case of Simultaneous, Very Late Thrombosis Involving Three Drug-Eluting Stents in Three Coronary Arteries

2008 ◽  
Vol 38 (10) ◽  
pp. 564 ◽  
Author(s):  
Yong Soo Ahn ◽  
Jang Hyun Cho ◽  
Dong Han Kim ◽  
Young June Hwang ◽  
Hong Myong Jung ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Fatal Case ◽  
Drug Eluting Stents ◽  
Drug Eluting ◽  
Late Thrombosis

Ongoing Late Lumen Loss with the CYPHER and TAXUS Drug-eluting Stents Supports a Theory of Catch-up Restenosis

2009 ◽  
Vol 4 (1) ◽  
pp. 57
Author(s):  
James Gilbart ◽  
Keyword(s):  
Drug Eluting Stents ◽  
Late Lumen Loss ◽  
Different Types ◽  
Critical Problems ◽  
Drug Eluting ◽  
Neointimal Coverage ◽  
Catch Up ◽  
Surgical Implantation ◽  
Late Luminal Loss

Luminal loss and restenosis are critical problems in coronary artery drug-eluting stents (DES). These implants need to minimise long-term neointimal coverage and maximise blood flow. Two studies compared the effects of different types of DES on lumen loss after surgical implantation. The first study included 2,030 patients and showed that over two years late luminal loss (termed ‘late luminal creep’) progressed for two types of commercially prepared permanent polymer stents containing rapamycin or paclitaxel (CYPHER and TAXUS), but not for a polymer-free in-house coated stent containing rapamycin (YUKON). In a smaller study, luminal coverage was lower with the CYPHER than with the YUKON stent, but struts of the stent structure were better covered with the YUKON stent and less likely to cause an obstruction. Stents should ideally limit luminal loss but also allow for sufficient coverage to prevent thrombotic hazards.

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