AS-73: High-Density Lipoprotein Cholesterol Is an Independent Predictor of In-Hospital Adverse Events and Long-Term Clinical Outcome in ST-segment Elevation Myocardial Infarction

2009 ◽  
Vol 103 (9) ◽  
pp. 34B-35B
Author(s):  
Seo Na Hong ◽  
Myung Ho Jeong ◽  
Young Keun Ahn ◽  
Shung Chull Chae ◽  
Seung Ho Hur ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Clinical Outcome ◽  
Adverse Events ◽  
High Density Lipoprotein ◽  
Independent Predictor ◽  
Density Lipoprotein ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

scholarly journals Markers of Thrombin Generation Are Associated With Long-Term Clinical Outcome in Patients With ST-Segment Elevation Myocardial Infarction

2018 ◽  
Vol 24 (7) ◽  
pp. 1088-1094 ◽  
Author(s):  
Charlotte Holst Hansen ◽  
Vibeke Ritschel ◽  
Geir Øystein Andersen ◽  
Sigrun Halvorsen ◽  
Jan Eritsland ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Clinical Outcome ◽  
Total Mortality ◽  
Secondary Outcome ◽  
End Points ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
D Dimer

Hypercoagulability in ST-segment elevation myocardial infarction (STEMI) as related to long-term clinical outcome is not clarified. We aimed to investigate whether prothrombin fragment 1+2 (F1+2), d-dimer, and endogenous thrombin potential (ETP) measured in the acute phase of STEMI were associated with outcome. Blood samples were drawn median 24 hours after symptom onset in 987 patients with STEMI. Median follow-up time was 4.6 years. Primary outcome was a composite of all-cause mortality, reinfarction, stroke, unscheduled revascularization, or rehospitalization for heart failure; secondary outcome was total mortality. The number of combined end points/total mortality was 195/79. Higher levels of d-dimer and F1+2 were observed with both end points (all P < .005), whereas ETP was significantly lower ( P < .01). Dichotomized at medians, increased risk was observed for levels above median for F1+2 and d-dimer (combined end point P = .020 and P = .010 and total mortality P < .001, both), while an inverse pattern was observed for ETP ( P < .02, both). Adjusting for covariates, d-dimer was still associated with reduced risk of total mortality ( P = .034) and receiver operating characteristic curve analyses showed area under the curve of 0.700 (95% confidence interval, 0.640-0.758). The hypercoagulable state in acute STEMI seems to be of importance for clinical outcome.

scholarly journals Association of the Monocyte to HDL Cholesterol Ratio With Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction

2016 ◽  
Vol 23 (8) ◽  
pp. 992-997 ◽  
Author(s):  
Arif Arısoy ◽  
Fatih Altunkaş ◽  
Kayıhan Karaman ◽  
Metin Karayakalı ◽  
Ataç Çelik ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Independent Predictor ◽  
Characteristic Curve ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Monocyte Count ◽  
St Segment Elevation ◽  
Cholesterol Ratio ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

Intracoronary thrombus burden is associated with some adverse events and poor prognosis in patients with ST-segment elevation myocardial infarction (STEMI). Identifying predictors of the intracoronary thrombus burden may contribute to the management of STEMI. In this study, we evaluated whether monocyte count to high-density lipoprotein cholesterol ratio (MHR) is a predictor of intracoronary thrombus burden in patients with STEMI. The study population consisted of 414 patients with STEMI who underwent primary percutaneous coronary intervention (PCI). Angiographic thrombus burden was classified based on thrombolysis in myocardial infarction (TIMI) thrombus grades. The patients were grouped into 2 categories of low thrombus burden and high thrombus burden. The MHR was significantly higher in the high thrombus burden group compared with the low thrombus group (16.0 [9.2-22.1] vs 25.4 [13.5-44.6]; P < .001). In multivariate logistic regression analysis, MHR was an independent predictor of high thrombus burden (odds ratio: 1.067, 95% CI: 1.031-1.105; P < .001). The area under the receiver–operating characteristic curve of the MHR was 0.688 (0.641-0.733; P < .001) to predict high thrombus burden. In conclusion, MHR was independent predictor of high thrombus burden in patients with STEMI who underwent primary PCI.

scholarly journals Profil lipid pada wanita dengan sindrom koroner akut

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Ronaldi . ◽  
Ike Adriana ◽  
Monique Rotty ◽  
Reginald L. Lefrandt ◽  
Agnes L. Panda
Keyword(s):  
Myocardial Infarction ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
St Elevation ◽  
The Mean

Abstract: Females with acute coronary syndrome (ACS) display different characteristics from the opposite gender. Currently, only limited data were available regarding the characteristic of ACS in females, especially in Manado. This study aimed to obtain the lipid profile of females with ACS at Prof. Dr. R. D. Kandou Hospital Manado in 2012-2013. This was a descriptive retrospective study with a cross sectional design. Subjects were all female patients with ACS who were admitted to Prof. Dr. R. D. Kandou Hospital Manado from January 2012 to December 2013. Data were collected based on the medical record. Exclusion criteria included incomplete data and non-ACS as the main diagnosis. There were 81 women as subjects in this study. The mean age was 61.59±10.78 years. Unstable angina pectoris, non-ST elevation myocardial infarction, ST elevation myocardial infarction were found in 38 (46.9%), 15 (18.5%), and 28 (34.6%) patients consecutively. Mean value of total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), and trygliserida levels were as follows: 218.17±48.88, 145.91±47.30, 39.72±15.99, and 153±65.55 mg/dl. High level of total cholesterol, LDL, and trygliserida were found in 52 (64.2%), 50 (61.7%), 14 (17.3%) patients consecutively meanwhile low HDL level was found in 51(63%) patients. Diabetes mellitus and hypertension were found in 24 (29.6%) and 58 (71.6%) patients. The mean length of stay was 8.44±4.36 days.Keywords: female, lipid profile, acute coronary syndromeAbstrak: Wanita dengan sindrom koroner akut (SKA) menampilkan karakteristik yang berbeda daripada laki-laki dengan SKA. Sampai saat ini, masih tersedia sedikit data mengenai karakteristik SKA pada wanita. Penelitian ini bertujuan mendapatkan gambaran profil lipid pada wanita dengan SKA yang dirawat di RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ini deskriptif retrospektif dengan desain potong lintang. Subyek penelitian ialah pasien wanita dengan SKA yang dirawat di RSUP Prof. Dr. R. D. Kandou, Manado dari Januari 2012-Desember 2013. Data dikumpulkan dari rekam medis. Kriteria eksklusi meliputi data yang tidak lengkap dan diagnosis selain SKA sebagai diagnosis utama. Hasil penelitian mendapatkan subyek 81 pasien wanita dengan usia rata-rata 61,59±10,78 tahun. Angina pektoris tak stabil ditemukan pada 38 pasien (46,9%), non-ST segment elevation myocardial infarction pada 15 pasien (18,5%), dan ST segment elevation myocardial infarction pada 28 pasien (34,6%). Kadar rerata kolesterol total, low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida ialah berturut-turut 218,17±48,88, 145,91±47,30, 39,72±15,99, dan 153±65,55 mg/dl. Kadar kolesterol total, LDL, trigliserida yang tinggi ditemukan berturut-turut pada 52 pasien (64,2%), 50 pasien (61,7%), dan 14 pasien (17,3%) sedangkan kadar HDL yang rendah ditemukan pada 51 pasien (63%). Diabetes melitus dan hipertensi ditemukan pada 24 pasien (29,6%) dan 58 pasien (71,6%). Rerata lama perawatan di rumah sakit ialah 8,44±4,36 hari.Kata kunci: wanita, profil lipid, sindrom koroner akut

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