TCT-208: Elinogrel, A Novel Direct-acting P2Y12 Antagonist Overcomes High Platelet Reactivity in Patients on Dual Antiplatelet Therapy Independent of CYP 2C19*2 Genotype

2009 ◽  
Vol 104 (6) ◽  
pp. 80D
Keyword(s):  
Antiplatelet Therapy ◽  
Dual Antiplatelet Therapy ◽  
Platelet Reactivity ◽  
High Platelet Reactivity ◽  
Direct Acting ◽  
P2y12 Antagonist

Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report

Platelets ◽  
2014 ◽  
Vol 26 (6) ◽  
pp. 593-597 ◽  
Author(s):  
Bernadeta Chyrchel ◽  
Justyna Totoń-Żurańska ◽  
Olga Kruszelnicka ◽  
Michał Chyrchel ◽  
Waldemar Mielecki ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antiplatelet Therapy ◽  
Preliminary Report ◽  
Dual Antiplatelet Therapy ◽  
Platelet Reactivity ◽  
Artery Disease

Postmenopausal women have an increased maximal platelet reactivity compared to men despite dual antiplatelet therapy

2012 ◽  
Vol 23 (8) ◽  
pp. 723-728 ◽  
Author(s):  
Peter Bobbert ◽  
Caroline Stellbaum ◽  
Daniel Steffens ◽  
Claudia Schütte ◽  
Thomas Bobbert ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Antiplatelet Therapy ◽  
Dual Antiplatelet Therapy ◽  
Platelet Reactivity

scholarly journals Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

2021 ◽  
Vol 22 (6) ◽  
pp. 3180
Author(s):  
Nina Đukanović ◽  
Slobodan Obradović ◽  
Marija Zdravković ◽  
Siniša Đurašević ◽  
Maja Stojković ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Antiplatelet Therapy ◽  
Dual Antiplatelet Therapy ◽  
Platelet Reactivity ◽  
Rebound Effect ◽  
Major Adverse Cardiovascular Events ◽  
Future Perspectives ◽  
Organ Specific ◽  
Rebound Phenomenon ◽  
Platelet Functions

Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.

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