Meta-Analysis of Cytochrome P450 2C19 Polymorphism and Risk of Adverse Clinical Outcomes Among Coronary Artery Disease Patients of Different Ethnic Groups Treated With Clopidogrel

2012 ◽  
Vol 110 (4) ◽  
pp. 502-508 ◽  
Author(s):  
Jae-Sik Jang ◽  
Kyoung-Im Cho ◽  
Han-Young Jin ◽  
Jeong-Sook Seo ◽  
Tae-Hyun Yang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cytochrome P450 ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Ethnic Groups ◽  
Meta Analysis ◽  
Cytochrome P450 2C19 ◽  
Artery Disease

Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xinyi Zhang ◽  
Sicong Li ◽  
Yuxuan Zhao ◽  
Ningjia Tang ◽  
Tong Jia ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Electronic Database ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship ◽  
Ischemic Events

Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searched the electronic database for articles on the relationship of PEAR1 SNPs and ischemic events in patients with coronary artery disease (CAD) up to October 2020. Results: A total of 9914 patients with CAD from six studies focusing on 12 SNPs of PEAR1 were included in this study. The A allele of rs12041331 were associated with ischemic events (odds ratio: 1.40; 95% CI: 1.04–1.88; p = 0.03). The AA homozygotes of rs2768759 was related to a higher risk of ischemic events than carriers of the C allele (odds ratio: 2.08; 95% CI: 1.09–3.97; p = 0.03). Conclusion: PEAR1 rs12041331 and rs2768759 are significantly associated with ischemic events in patients with CAD.

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