Comparison of a Two-lead, Computerized, Resting ECG Signal Analysis Device, The Multifunction-Cardiogram((MCG), to Coronary Angiography or MDCT for The Detection of Prevalent Coronary Artery Stenosis

2013 ◽  
Vol 111 (7) ◽  
pp. 46B
Author(s):  
Keiko Hatazawa ◽  
Makoto Kadotani ◽  
Hiroaki Matsuzoe ◽  
Takayuki Tsuji ◽  
Michihiko Inoue ◽  
...  
2013 ◽  
Vol 6 (3) ◽  
pp. 262-268 ◽  
Author(s):  
Song Jiangping ◽  
Zheng Zhe ◽  
Wang Wei ◽  
Song Yunhu ◽  
Huang Jie ◽  
...  

2004 ◽  
Vol 128 (11) ◽  
pp. 1263-1266
Author(s):  
Michele T. Stauffenberg ◽  
Richard A. Lange ◽  
L. David Hillis ◽  
Joaquin Cigarroa ◽  
Rebecca M. Hsu ◽  
...  

Abstract Context.—Homocysteine is emerging as a novel marker of atherothrombosis. Its role as an independent risk factor for cardiovascular disease is generally accepted. There is scanty data correlating homocysteine levels measured by immunoassay with cardiovascular disease. We previously validated a fluorescence polarization immunoassay for measuring homocysteine, which compared favorably with high performance liquid chromatography. Objective.—To determine if homocysteine levels measured by immunoassay correlate with extent of atherosclerotic burden, as represented by degree of coronary artery stenosis determined by coronary angiography. Design.—Fasting plasma samples were obtained from patients undergoing coronary angiography (N = 165). Homocysteine levels were measured by immunoassay and coronary artery stenosis was determined by coronary angiography. Results.—Median coronary artery stenosis for the 3 homocysteine subgroups, less than 1.35, 1.35 to 6.75, and greater than 6.75 mg/L (<10, 10–15, and >15 μmol/L), was 75%, 90%, and 99%, respectively (P = .01 for trend). Also, folate and vitamin B12 levels decreased with increasing homocysteine levels (P = .01 and .04, respectively, for trend). Spearman's correlation showed a significant association between homocysteine level and coronary artery stenosis (r = 0.20; P = .009). When men and women were examined separately, the correlation was significant only for women (r = 0.30; P = .01). Conclusion.—Homocysteine levels, as measured by immunoassay, show a positive correlation with cardiovascular disease in women. Thus, this is a valid measure of atherosclerotic burden and, therefore, a reliable addition to the established laboratory repertoire for the assessment of cardiovascular disease.


2020 ◽  
Vol 46 (2) ◽  
pp. 150-157 ◽  
Author(s):  
A. Mantovani ◽  
S. Bonapace ◽  
G. Lunardi ◽  
G. Canali ◽  
C. Dugo ◽  
...  

2000 ◽  
Vol 83 (06) ◽  
pp. 822-825 ◽  
Author(s):  
Antoine Da Costa ◽  
Stéphane Munier ◽  
Bernard Mercier ◽  
Brigitte Tardy ◽  
Claude Ferec ◽  
...  

SummaryFactor V Leiden is associated with an increased risk of venous thrombosis and myocardial infarction in young women, but not in men in this latter case. The aim of this study was to evaluate the prevalence of this mutation in patients with myocardial infarction but normal coronary angiography.We compared 3 groups of patients: one group consisted of 107 patients with premature myocardial infarction but no significant coronary artery stenosis; another group of 244 patients with myocardial infarction and significant coronary artery stenosis; a third group of 400 healthy controls.Factor V Leiden was found in 13 patients (12.1%) who had a myocardial infarction without significant coronary artery stenosis, 11 patients (4.5%) who had a myocardial infarction with significant coronary artery stenosis (p = 0.01) and in 20 controls (5%) (p = 0.01). Odds ratio associated with factor V Leiden were respectively 2.93 (CI95 : 1.18-7.31) and 2.63 (CI95 : 1.19-5.78) when we compared myocardial infarction patients without significant coronary artery stenosis to controls or to patients with significant coronary artery stenosis.In myocardial infarction patients without significant coronary artery stenosis, prevalence of factor V Leiden is significantly higher than in controls. This new finding supports the hypothesis that thrombosis plays a key role in this selected situation.


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