1114P Comparative study of combined large cell neuroendocrine carcinoma and combined small cell carcinoma in resected high-grade neuroendocrine tumors of the lung

2021 ◽  
Vol 32 ◽  
pp. S917
Author(s):  
Y. Wang ◽  
B. Han
Keyword(s):  
Comparative Study ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
High Grade ◽  
Combined Small Cell Carcinoma

The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung

Lung Cancer ◽  
2011 ◽  
Vol 74 (3) ◽  
pp. 405-410 ◽  
Author(s):  
Ryo Nasgashio ◽  
Yuichi Sato ◽  
Toshihide Matsumoto ◽  
Taihei Kageyama ◽  
Manabu Hattori ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma

Small Cell Carcinoma of the Uterine Cervix with Large Cell Neuroendocrine Carcinoma Component

1998 ◽  
Vol 68 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Mei-Hua Tsou ◽  
Tran-Der Tan ◽  
Skye H. Cheng ◽  
Yahn-Kun Chiou
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Uterine Cervix ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma

Immunohistochemical Expression of Estrogen and Progesterone Receptors in Primary Pulmonary Neuroendocrine Tumors

2008 ◽  
Vol 132 (12) ◽  
pp. 1889-1895
Author(s):  
Gabriel Sica ◽  
Patrick L. Wagner ◽  
Nassar Altorki ◽  
Jeffrey Port ◽  
Paul C. Lee ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Tumors ◽  
Progesterone Receptors ◽  
Large Cell ◽  
Small Cell ◽  
Neuroendocrine Neoplasms ◽  
Typical Carcinoid ◽  
Combined Small Cell Carcinoma ◽  
Estrogen And Progesterone Receptor

Abstract Context.—Lung and breast carcinomas are among the most prevalent cancers. Advances in cancer therapies can provide survival benefit and be potentially curative, even in metastatic disease. Due to the high prevalence of these carcinomas, it is not unusual to encounter lung nodule(s) in a patient with breast carcinoma, and distinguishing between primary and metastatic disease is critical for management/treatment. Occasionally neuroendocrine differentiation is present in breast carcinoma, making its distinction from pulmonary/nonpulmonary neuroendocrine tumors in the lung difficult. Objective.—To assess estrogen and progesterone receptor expression in the entire spectrum of pulmonary neuroendocrine tumors. Design.—Seventy-one neuroendocrine neoplasms including typical carcinoids (42), atypical carcinoids (7), small cell carcinomas (14), large cell neuroendocrine carcinomas (2), and combined small cell carcinomas (6) were evaluated for estrogen and progesterone receptors. Mammary and non–small cell lung carcinomas were also stained for comparison. Results.—The entire spectrum of neuroendocrine neoplasms demonstrated focal to diffuse estrogen (typical carcinoid, 23; atypical carcinoid, 6; small cell carcinoma, 8; large cell neuroendocrine carcinoma, 2; combined small cell carcinoma, 4) and progesterone (typical carcinoid, 11; atypical carcinoid, 2; small cell carcinoma, 7; large cell neuroendocrine carcinoma, 0; combined small cell carcinoma, 2) expression. There was no correlation between sex and estrogen/progesterone status. Estrogen and progesterone staining were also noted in endothelial cells. Relative to neuroendocrine carcinomas, mammary carcinomas expressed estrogen and progesterone more frequently. Non–small cell carcinomas had greater and similar immunoreactivity for estrogen and progesterone, respectively. Conclusions.—Although estrogen and progesterone receptor staining is frequently associated with breast and gynecologic primaries, it can also be observed in “nontarget” organs. Therefore, presence of estrogen and/or progesterone expression in neuroendocrine tumors involving the lung should not exclude a primary pulmonary neoplasm.

scholarly journals Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung

2010 ◽  
Vol 5 (4) ◽  
pp. 472-478 ◽  
Author(s):  
Rira Hoshi ◽  
Noriyuki Furuta ◽  
Takeshi Horai ◽  
Yuichi Ishikawa ◽  
Satoshi Miyata ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Discriminant Model

Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma

2008 ◽  
Vol 453 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Giovanni Fellegara ◽  
Tiziana D’Adda ◽  
Francesco P. Pilato ◽  
Elisabetta Froio ◽  
Luca Ampollini ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma
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