scholarly journals 287P Burden of illness of HER2+ in metastatic breast cancer (MBC) patients: A systematic literature review (SLR)

2021 ◽  
Vol 32 ◽  
pp. S490
Author(s):  
G. Vondeling ◽  
T. Harding ◽  
A. Seddik ◽  
K. Bakker ◽  
R. Velikanova
2020 ◽  
Vol 20 (3) ◽  
pp. e232-e243 ◽  
Author(s):  
Lea E. Mollon ◽  
Elizabeth J. Anderson ◽  
Joni L. Dean ◽  
Terri L. Warholak ◽  
Ayal Aizer ◽  
...  

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13037-e13037 ◽  
Author(s):  
Elizabeth J Anderson ◽  
Lea Mollon ◽  
Joni L Dean ◽  
Alejandra Aguilar ◽  
Lisa E. Davis ◽  
...  

2021 ◽  
Author(s):  
Nadia Harbeck ◽  
Meaghan Bartlett ◽  
Dean Spurden ◽  
Becky Hooper ◽  
Lin Zhan ◽  
...  

Background: This review aims to qualitatively summarize the published real-world evidence (RWE) for CDK4/6 inhibitors (CDK4/6i) approved for treating HR+, HER2-negative advanced/metastatic breast cancer (HR+/HER2- a/mBC). Materials & methods: A systematic literature review was conducted to identify RWE studies of CDK4/6i in HR+/HER2- a/mBC published from 2015 to 2019. Results: This review identified 114 studies, of which 85 were only presented at scientific conferences. Most RWE studies investigated palbociclib and demonstrated improved outcomes. There are limited long-term and comparative data between CDK4/6i and endocrine monotherapy, and within the CDK4/6i class. Conclusion: Available RWE suggests that CDK4/6i are associated with improved outcomes in HR+/HER2- a/mBC, although additional studies with longer follow-up periods are needed.


The Breast ◽  
2015 ◽  
Vol 24 ◽  
pp. S39
Author(s):  
Rachel Würstlein ◽  
Maximilian Bardenhewer ◽  
Alexander König ◽  
Thomas Kolben ◽  
Caroline Gehring ◽  
...  

2019 ◽  
Vol 130 ◽  
pp. 267-270
Author(s):  
Yoshifumi Tao ◽  
Kenji Yagi ◽  
Hirotake Nishimura ◽  
Keijirou Hara ◽  
Shunji Matsubara ◽  
...  

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