Bioactive Marine Xanthones: A Review

The marine environment is an important source of specialized metabolites with valuable biological activities. Xanthones are a relevant chemical class of specialized metabolites found in this environment due to their structural variety and their biological activities. In this work, a comprehensive literature review of marine xanthones reported up to now was performed. A large number of bioactive xanthone derivatives (169) were identified, and their structures, biological activities, and natural sources were described. To characterize the chemical space occupied by marine-derived xanthones, molecular descriptors were calculated. For the analysis of the molecular descriptors, the xanthone derivatives were grouped into five structural categories (simple, prenylated, O-heterocyclic, complex, and hydroxanthones) and six biological activities (antitumor, antibacterial, antidiabetic, antifungal, antiviral, and miscellaneous). Moreover, the natural product-likeness and the drug-likeness of marine xanthones were also assessed. Marine xanthone derivatives are rewarding bioactive compounds and constitute a promising starting point for the design of other novel bioactive molecules.

Diabetes Distal Peripheral Neuropathy: Subtypes and Diagnostic and Screening Technologies

Diabetes distal symmetrical peripheral neuropathy (DSPN) is the most prevalent form of neuropathy in industrialized countries, substantially increasing risk for morbidity and pre-mature mortality. DSPN may manifest with small-fiber disease, large-fiber disease, or a combination of both. This review summarizes: (1) DSPN subtypes (small- and large-fiber disease) with attention to clinical signs and patient symptoms; and (2) technological diagnosis and screening for large- and small-fiber disease with inclusion of a comprehensive literature review of published studies from 2015-present ( N = 66). Review findings, informed by the most up-to-date research, advance critical understanding of DSPN large- and small-fiber screening technologies, including those designed for point-of-care use in primary care and endocrinology practices.

HOAX MENJADI GANGGUAN KESEJAHTERAAN MASYARAKAT: PENTINGNYA IMPLEMENTASI TABAYYUN PADA MASA SEKARANG

This paper aims to discuss rights of non-Muslim citizens in Indonesia at government refers to the conception of the state of Dien wa Ni'mah. The main argument in this paper that the concept of Dien wa Ni'mah prioritize law as an important pillar can accommodate pluralism and contextual with the system of the Unitary State of the Republic Indonesia based on Pancasila. The research method used was a historical study, based on a comprehensive literature review from various sources in books and journals about the concept of Dien wa Ni'mah. The results of this study explain that Dien wa Ni'mah is a concept of the manifestation of Islam as a religious teaching that is Rahmatan Li al-Alamin and build human life through law as the main universal pillar, not only as the theological framework and spiritual principles of mankind, also in the life of society, nation and religion. So this concept accommodates the rights of non-Muslims in government by considering pluralism and democracy. Thus making the concept of Dien wa Ni'mah as the nation's perspective to the Civil Society will have an impact on the participation of all parties.

Salutogenesis: Sense of Coherence in Childhood and Families

In this chapter on salutogenesis and sense of coherence (SOC) in families and children, the authors deal with the contributions of children’s environments to the adjustment of children with typical development, and the development of children with special needs. The authors report on their comprehensive literature review covering 20 years of research and 44 studies from 15 countries, including children from infants and toddlers through preschool to school-aged children up to 12 years of age.

Audits in Cybersecurity

The objective of this chapter is to provision a comprehensive literature review of the most relevant approaches for conducting cybersecurity audits. The study includes auditing perspectives for specific scopes and the best practices that many leading organizations are providing for security and auditing professionals to follow. The chapter reviews relevant features for auditing approaches in the following order: ISO/IEC 27001:2013, ISO/IEC 27002:2013, Control Objectives for Information and Related Technology (COBIT) 2019, Information Technology Infrastructure Library (ITIL) 4, AICPA, ISACA, NIST SP 800-53, NIST CSF v1.1, IIA, PCI DSS, ITAF, COSO, ENISA, NERC CIP, and CSAM.