1140P Validation of a deep learning model for the classification of lung cancer in a large cohort of biopsied samples

2021 ◽  
Vol 32 ◽  
pp. S926-S927
Author(s):  
G. Toyokawa ◽  
Y. Yamada ◽  
N. Haratake ◽  
Y. Shiraishi ◽  
T. Takenaka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Large Cohort ◽  
Deep Learning Model

scholarly journals A deep learning model for the classification of indeterminate lung carcinoma in biopsy whole slide images

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fahdi Kanavati ◽  
Gouji Toyokawa ◽  
Seiya Momosaki ◽  
Hiroaki Takeoka ◽  
Masaki Okamoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Area Under The Curve ◽  
Learning Model ◽  
Primary Sources ◽  
Independent Test ◽  
Hematoxylin And Eosin ◽  
Deep Learning Model ◽  
Whole Slide Images

AbstractThe differentiation between major histological types of lung cancer, such as adenocarcinoma (ADC), squamous cell carcinoma (SCC), and small-cell lung cancer (SCLC) is of crucial importance for determining optimum cancer treatment. Hematoxylin and Eosin (H&E)-stained slides of small transbronchial lung biopsy (TBLB) are one of the primary sources for making a diagnosis; however, a subset of cases present a challenge for pathologists to diagnose from H&E-stained slides alone, and these either require further immunohistochemistry or are deferred to surgical resection for definitive diagnosis. We trained a deep learning model to classify H&E-stained Whole Slide Images of TBLB specimens into ADC, SCC, SCLC, and non-neoplastic using a training set of 579 WSIs. The trained model was capable of classifying an independent test set of 83 challenging indeterminate cases with a receiver operator curve area under the curve (AUC) of 0.99. We further evaluated the model on four independent test sets—one TBLB and three surgical, with combined total of 2407 WSIs—demonstrating highly promising results with AUCs ranging from 0.94 to 0.99.

scholarly journals 364P A deep learning model for the classification of lung cancer

2020 ◽  
Vol 31 ◽  
pp. S1381
Author(s):  
G. Toyokawa ◽  
F. Kanavati ◽  
S. Momosaki ◽  
K. Tateishi ◽  
H. Takeoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Deep Learning Model

Optimal deep learning model for classification of lung cancer on CT images

2019 ◽  
Vol 92 ◽  
pp. 374-382 ◽  
Author(s):  
Lakshmanaprabu S.K. ◽  
Sachi Nandan Mohanty ◽  
Shankar K. ◽  
Arunkumar N. ◽  
Gustavo Ramirez
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Ct Images ◽  
Deep Learning Model

Detection and classification of arrhythmia using an explainable deep learning model

2021 ◽  
Author(s):  
Yong-Yeon Jo ◽  
Joon-myoung Kwon ◽  
Ki-Hyun Jeon ◽  
Yong-Hyeon Cho ◽  
Jae-Hyun Shin ◽  
...  
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
Deep Learning Model

Deep learning to predict subtypes of poorly differentiated lung cancer from biopsy whole slide images.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 8536-8536
Author(s):  
Gouji Toyokawa ◽  
Fahdi Kanavati ◽  
Seiya Momosaki ◽  
Kengo Tateishi ◽  
Hiroaki Takeoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Test Set ◽  
Cancer Subtypes ◽  
Independent Test ◽  
Poorly Differentiated ◽  
Test Sets ◽  
Deep Learning Model ◽  
Whole Slide Images

8536 Background: Lung cancer is the leading cause of cancer-related death in many countries, and its prognosis remains unsatisfactory. Since treatment approaches differ substantially based on the subtype, such as adenocarcinoma (ADC), squamous cell carcinoma (SCC) and small cell lung cancer (SCLC), an accurate histopathological diagnosis is of great importance. However, if the specimen is solely composed of poorly differentiated cancer cells, distinguishing between histological subtypes can be difficult. The present study developed a deep learning model to classify lung cancer subtypes from whole slide images (WSIs) of transbronchial lung biopsy (TBLB) specimens, in particular with the aim of using this model to evaluate a challenging test set of indeterminate cases. Methods: Our deep learning model consisted of two separately trained components: a convolutional neural network tile classifier and a recurrent neural network tile aggregator for the WSI diagnosis. We used a training set consisting of 638 WSIs of TBLB specimens to train a deep learning model to classify lung cancer subtypes (ADC, SCC and SCLC) and non-neoplastic lesions. The training set consisted of 593 WSIs for which the diagnosis had been determined by pathologists based on the visual inspection of Hematoxylin-Eosin (HE) slides and of 45 WSIs of indeterminate cases (64 ADCs and 19 SCCs). We then evaluated the models using five independent test sets. For each test set, we computed the receiver operator curve (ROC) area under the curve (AUC). Results: We applied the model to an indeterminate test set of WSIs obtained from TBLB specimens that pathologists had not been able to conclusively diagnose by examining the HE-stained specimens alone. Overall, the model achieved ROC AUCs of 0.993 (confidence interval [CI] 0.971-1.0) and 0.996 (0.981-1.0) for ADC and SCC, respectively. We further evaluated the model using five independent test sets consisting of both TBLB and surgically resected lung specimens (combined total of 2490 WSIs) and obtained highly promising results with ROC AUCs ranging from 0.94 to 0.99. Conclusions: In this study, we demonstrated that a deep learning model could be trained to predict lung cancer subtypes in indeterminate TBLB specimens. The extremely promising results obtained show that if deployed in clinical practice, a deep learning model that is capable of aiding pathologists in diagnosing indeterminate cases would be extremely beneficial as it would allow a diagnosis to be obtained sooner and reduce costs that would result from further investigations.

scholarly journals Attention-Guided Digital Adversarial Patches on Visual Detection

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Dapeng Lang ◽  
Deyun Chen ◽  
Ran Shi ◽  
Yongjun He
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
Detection Algorithm ◽  
Classification Model ◽  
Practical Application ◽  
Single Target ◽  
Attachment Mechanism ◽  
Human Eyes ◽  
Deep Learning Model

Deep learning has been widely used in the field of image classification and image recognition and achieved positive practical results. However, in recent years, a number of studies have found that the accuracy of deep learning model based on classification greatly drops when making only subtle changes to the original examples, thus realizing the attack on the deep learning model. The main methods are as follows: adjust the pixels of attack examples invisible to human eyes and induce deep learning model to make the wrong classification; by adding an adversarial patch on the detection target, guide and deceive the classification model to make it misclassification. Therefore, these methods have strong randomness and are of very limited use in practical application. Different from the previous perturbation to traffic signs, our paper proposes a method that is able to successfully hide and misclassify vehicles in complex contexts. This method takes into account the complex real scenarios and can perturb with the pictures taken by a camera and mobile phone so that the detector based on deep learning model cannot detect the vehicle or misclassification. In order to improve the robustness, the position and size of the adversarial patch are adjusted according to different detection models by introducing the attachment mechanism. Through the test of different detectors, the patch generated in the single target detection algorithm can also attack other detectors and do well in transferability. Based on the experimental part of this paper, the proposed algorithm is able to significantly lower the accuracy of the detector. Affected by the real world, such as distance, light, angles, resolution, etc., the false classification of the target is realized by reducing the confidence level and background of the target, which greatly perturbs the detection results of the target detector. In COCO Dataset 2017, it reveals that the success rate of this algorithm reaches 88.7%.

Sign in / Sign up

Export Citation Format

Share Document