Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions

2009 ◽  
Vol 83 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Joeri Auwerx ◽  
Katrien O. François ◽  
Els Vanstreels ◽  
Kristel Van Laethem ◽  
Dirk Daelemans ◽  
...  
Keyword(s):  
Carbohydrate Binding ◽  
Binding Agents ◽  
Hiv 1

scholarly journals Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents

2013 ◽  
Vol 68 (9) ◽  
pp. 2026-2037 ◽  
Author(s):  
M. I. Petrova ◽  
L. Mathys ◽  
S. Lebeer ◽  
S. Noppen ◽  
E. J. M. Van Damme ◽  
...  
Keyword(s):  
Carbohydrate Binding ◽  
Binding Agents ◽  
Hiv 1

scholarly journals Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin

2015 ◽  
Vol 96 (12) ◽  
pp. 3660-3666 ◽  
Author(s):  
Bodan Hu ◽  
Tao Du ◽  
Chang Li ◽  
Sukun Luo ◽  
Yalan Liu ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Carbohydrate Binding ◽  
Immunodeficiency Virus ◽  
Binding Agents ◽  
Galanthus Nivalis ◽  
Hiv 1 ◽  
Microbicide Candidate

Human immunodeficiency virus type 1 (HIV-1) transmission often results from infection by a single transmitted/founder (T/F) virus. Here, we investigated the sensitivity of T/F HIV-1 envelope glycoproteins (Envs) to microbicide candidate carbohydrate-binding agents (CBAs) griffithsin (GRFT), cyanovirin-N (CV-N) and Galanthus nivalis agglutinin (GNA), showing that T/F Envs demonstrated different sensitivity to CBAs, with IC50 values ranging from 0.006 ± 0.0003 to >10 nM for GRFT, from 0.6 ± 0.2 to 28.9 ± 2.9 nM for CV-N and from 1.3 ± 0.2 to >500 nM for GNA. We further revealed that deglycosylation at position 295 or 448 decreased the sensitivity of T/F Env to GRFT, and at 339 to both CV-N and GNA. Mutation of all the three glcyans rendered a CBA-sensitive T/F Env largely resistant to GRFT, indicating that the sensitivity of T/F Env to GRFT is mainly determined by glycans at 295, 339 and 448. Our study identified specific T/F Env residues associated with CBA sensitivity.

scholarly journals HIV-1 envelope trimer has similar binding characteristics for carbohydrate-binding agents as monomeric gp120

FEBS Letters ◽  
2013 ◽  
Vol 587 (7) ◽  
pp. 860-866 ◽  
Author(s):  
Bart Hoorelbeke ◽  
Thijs van Montfort ◽  
Jie Xue ◽  
Patricia J. LiWang ◽  
Haruo Tanaka ◽  
...  
Keyword(s):  
Carbohydrate Binding ◽  
Binding Characteristics ◽  
Binding Agents ◽  
Monomeric Gp120 ◽  
Hiv 1

scholarly journals HIV-1 and Its Resistance to Peptidic Carbohydrate-Binding Agents (CBAs): An Overview

Molecules ◽  
2014 ◽  
Vol 19 (12) ◽  
pp. 21085-21112 ◽  
Author(s):  
Geoffrey Férir ◽  
Stephanie Gordts ◽  
Dominique Schols
Keyword(s):  
Carbohydrate Binding ◽  
Binding Agents ◽  
Hiv 1
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