New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach

2018 ◽  
Vol 201 ◽  
pp. 151-161 ◽  
Author(s):  
Yi Liu ◽  
Muhammad Junaid ◽  
Yan Wang ◽  
Yu-Mei Tang ◽  
Wan-Ping Bian ◽  
...  
Keyword(s):  
Toxicity Estimation

Clove Constituents as new leads for the Design and development of Multi-targeted Anti-Alzheimer activity

2021 ◽  
pp. 3515-3522
Author(s):  
Safiya Sultana T ◽  
Sivakumar M
Keyword(s):  
Virtual Screening ◽  
Oleanolic Acid ◽  
Docking Simulation ◽  
In Vitro Assays ◽  
Syzygium Aromaticum ◽  
Potential Candidate ◽  
Multiple Targets ◽  
Target Action ◽  
Anti Oxidant ◽  
Toxicity Estimation

Objective: To use virtual screening analysis to screen out the phytoconstituents of Syzygium aromaticum against multiple targets of AD and determine its anti-oxidant and inflammatory inhibitory property. Methods: The compounds listed out from Syzygium aromaticum were subjected to virtual screening based on their drug likeness property and bioactivity scores. The molecular docking simulation such as HEX 8.0, PyRx, MVD along with Auto Dock 4.2 were employed to determine the potential candidate for providing activity against multiple targets of AD. The toxicity estimation was also carried out using TEST software. The potential candidate was further evaluated using DPPH, FRAT, Albumin denaturation and Proteinase inhibition method. Results: Only eight phytoconstituents were selected for virtual screening as they possessed drug likeness property and better bioactivity score for inhibition of kinases, proteases and enzymes. The docking results from various tools predicted that Oleanolic acid can be considered as potential constituents for multi-target action against AD. Toxicity estimation was in range. It also exhibited anti-oxidant and inflammatory inhibition providing its evidence for anti-AD activity. Conclusion: Taken together, these virtual screening results and in-vitro assays suggest that Oleanolic acid has multi target action against AD, which can be proved further with in-vivo studies.

Toxicity estimation of magnetic fluids in a biological test

2006 ◽  
Vol 304 (1) ◽  
pp. e406-e408 ◽  
Author(s):  
S.I. Park ◽  
J.H. Lim ◽  
J.H. Kim ◽  
H.I. Yun ◽  
C.O. Kim
Keyword(s):  
Magnetic Fluids ◽  
Biological Test ◽  
Toxicity Estimation

A toxicity estimation system for individual hydrocarbons in the monitoring loop of emergency oil spills on water bodies

2014 ◽  
Vol 75 (11) ◽  
pp. 2023-2033
Author(s):  
O. P. Avandeeva ◽  
G. M. Barenboim ◽  
V. M. Borisov ◽  
A. Yu. Saveka ◽  
I. A. Stepanovskaya ◽  
...  
Keyword(s):  
Oil Spills ◽  
Water Bodies ◽  
Estimation System ◽  
Individual Hydrocarbons ◽  
Toxicity Estimation
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