scholarly journals Refinement of an OECD test guideline for evaluating the effects of endocrine disrupting chemicals on aromatase gene expression and reproduction using novel transgenic cyp19a1a-eGFP zebrafish

2020 ◽  
Vol 220 ◽  
pp. 105403 ◽  
Author(s):  
Julie De Oliveira ◽  
Edith Chadili ◽  
Benjamin Piccini ◽  
Cyril Turies ◽  
Emmanuelle Maillot-Maréchal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endocrine Disrupting Chemicals ◽  
Aromatase Gene ◽  
Endocrine Disrupting ◽  
Test Guideline ◽  
Oecd Test Guideline ◽  
Aromatase Gene Expression

scholarly journals Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals

2001 ◽  
Vol 1 ◽  
pp. 653-655 ◽  
Author(s):  
Jennifer E. Fox ◽  
Matthew E. Burow ◽  
John A. McLachlan
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Estrogen Receptors ◽  
Mammalian Cell Culture ◽  
Endocrine Disrupting Chemicals ◽  
Gene Activation ◽  
Symbiotic Gene ◽  
Endocrine Disrupting ◽  
Plant Chemicals ◽  
By Products

Endocrine disrupting chemicals (EDCs) include organochlorine pesticides, plastics manufacturing by-products, and certain herbicides[1]. These chemicals have been shown to disrupt hormonal signaling in exposed wildlife, lab animals, and mammalian cell culture by binding to estrogen receptors (ER-α and ER-β) and affecting the expression of estrogen responsive genes[2,3]. Additionally, certain plant chemicals, termed phytoestrogens, are also able to bind to estrogen receptors and modulate gene expression, and as such also may be considered EDCs[4]. One example of phytoestrogen action is genistein, a phytochemical produced by soybeans, binding estrogen receptors, and changing expression of estrogen responsive genes which certain studies have linked to a lower incidence of hormonally related cancers in Japanese populations[5]. Why would plants make compounds that are able to act as estrogens in the human body? Obviously, soybeans do not intentionally produce phytoestrogens to prevent breast cancer in Japanese women.

Quantification of P450 aromatase gene expression in cultured and in vivo grown ovarian follicles in sheep

2014 ◽  
Vol 117 (1) ◽  
pp. 66-72 ◽  
Author(s):  
B.N.V. Lakshminarayana ◽  
V. Praveen Chakravarthi ◽  
K.V. Brahmaiah ◽  
V.H. Rao
Keyword(s):  
Gene Expression ◽  
Ovarian Follicles ◽  
Aromatase Gene ◽  
P450 Aromatase ◽  
Aromatase Gene Expression
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