Neoadjuvant tislelizumab combination chemotherapy for advanced penile cancer: A case report

Aims: Penile cancer is an uncommon malignancy in Western countries. There are known premalignant lesions that can progress to invasive penile cancer, namely carcinoma in situ (CIS) of the glans. Treatment options for this disease include topical chemotherapy and laser ablation, but the published literature demonstrates limited efficacy for these approaches. Surgical techniques with penile-preserving approaches are performed with the goal of removing the entire tumor and preserving as much of penis as possible. There are no large, randomized studies comparing treatment options for these lesions, and reports concerning the surgical approaches are scarce. Presentation of Case: In this study, we present a case report of a patient with CIS of the glans penis surgically treated with glans resurfacing. Discussion and Conclusions: There were no complications during follow-up, and after 20 months, the patient has no evidence of disease recurrence, has preserved urinary and erectile functions and is currently satisfied with the cosmetic appearance. CIS treatment with glans resurfacing allows the maintenance penile length and function with a good aesthetic result without compromising oncologic control. This approach also allows an accurate staging of the disease and assessment of the treatment efficacy.

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Intratumoral Hemorrhage in a Brain Metastasis from Breast Cancer during Combination Chemotherapy and Stereotactic Radiotherapy—A Case Report—

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.81.1482 ◽

2020 ◽

Vol 81 (8) ◽

pp. 1482-1488

Author(s):

Reiko YOSHIE ◽

Ei HAKU ◽

Hisanori KAWAMOTO ◽

Mamoru FUKUDA ◽

Yukinori OKADA ◽

...

Keyword(s):

Breast Cancer ◽

Case Report ◽

Brain Metastasis ◽

Combination Chemotherapy ◽

Stereotactic Radiotherapy ◽

Intratumoral Hemorrhage

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The Mote in thy Brother’s Eyes - Fusarium Solani in Leukemia Host

10.21203/rs.3.rs-787465/v1 ◽

2021 ◽

Author(s):

Rawan AlAgha ◽

Wee Lee Chan ◽

Thong Edwin Wei Sheng ◽

Joanne Lee ◽

Jen Wei Ying ◽

...

Keyword(s):

Case Report ◽

Early Diagnosis ◽

High Mortality ◽

Combination Chemotherapy ◽

Fusarium Solani ◽

Immunocompromised Host ◽

Skin Lesions ◽

Acute Onset ◽

Source Control ◽

Anti Fungal

Abstract Fusariosis is increasingly seen among immunocompromised host. The organism is known for its virulence and spectrum of infections. Presenting here a case of relapse acute myeloblastic leukemia on chemotherapy with acute onset of red painful eye followed by widespread painful skin lesions. Microbiological and radiological investigations diagnosed her with disseminated fusariosis. Treatment was challenging in view its inherent resistance to multiple anti-fungal agents and the need for early aggressive source control. The case report reflects the importance of early diagnosis and combination chemotherapy to salvage the patient from high mortality.

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Recurrent Metastatic Penile Cancer Patient with Positive PD-L1 Expression Obtained Significant Benefit from Immunotherapy: A Case Report and Literature Review

OncoTargets and Therapy ◽

10.2147/ott.s231258 ◽

2020 ◽

Vol Volume 13 ◽

pp. 3319-3324

Author(s):

Xiangyu Su ◽

Jing Zhang ◽

Chenchun Fu ◽

Mingzhe Xiao ◽

Cailian Wang

Keyword(s):

Case Report ◽

Literature Review ◽

Cancer Patient ◽

Penile Cancer ◽

Significant Benefit

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Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma

Case Reports in Oncology ◽

10.1159/000495344 ◽

2018 ◽

Vol 11 (3) ◽

pp. 835-841 ◽

Cited By ~ 1

Author(s):

Yohei Arihara ◽

Kazuyuki Murase ◽

Kohichi Takada ◽

Naotaka Hayasaka ◽

Shogo Miura ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Case Report ◽

Growth Factor ◽

Combination Chemotherapy ◽

Case Reports ◽

Growth Factor Receptor ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Her2 Positive ◽

Epidermal Growth ◽

The Right

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. We report here two cases of metastatic CXPA that were treated with trastuzumab-based chemotherapy (IRB approved) with rapid and significant responses. Case Report 1: A 66-year-old male was diagnosed as HER2-positive CXPA of the right lacrimal gland with multiple bone and lymph node metastases. Combination chemotherapy with trastuzumab (Tmab) and nanoparticle albumin-bound paclitaxel (nabPTX) was initiated. A rapid response was confirmed, and after seven cycles of treatment, CR(complete response) was achieved. Case Report 2: A 67-year-old female was diagnosed with HER2 positive CXPA of the right submandibular gland. Multiple pulmonary metastatic lesions were detected after surgery, and combination chemotherapy with Tmab and nab-PTX was initiated. A rapid partial response (PR) was confirmed, and she eventually became disease-free. Conclusion: In the absence of definitive clinical trials, which are unlikely to be performed due to the rarity of HER2-positive CXPA, therapeutic information must be obtained from case reports. Some reports, such as this one, have suggested a potential utility of trastuzumab-based chemotherapy.

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