scholarly journals The Mote in thy Brother’s Eyes - Fusarium Solani in Leukemia Host

2021 ◽  
Author(s):  
Rawan AlAgha ◽  
Wee Lee Chan ◽  
Thong Edwin Wei Sheng ◽  
Joanne Lee ◽  
Jen Wei Ying ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
High Mortality ◽  
Combination Chemotherapy ◽  
Fusarium Solani ◽  
Immunocompromised Host ◽  
Skin Lesions ◽  
Acute Onset ◽  
Source Control ◽  
Anti Fungal

Abstract Fusariosis is increasingly seen among immunocompromised host. The organism is known for its virulence and spectrum of infections. Presenting here a case of relapse acute myeloblastic leukemia on chemotherapy with acute onset of red painful eye followed by widespread painful skin lesions. Microbiological and radiological investigations diagnosed her with disseminated fusariosis. Treatment was challenging in view its inherent resistance to multiple anti-fungal agents and the need for early aggressive source control. The case report reflects the importance of early diagnosis and combination chemotherapy to salvage the patient from high mortality.

scholarly journals Occurrence of dermatomycosis (ringworm) due to Trichophyton verrucosumin dairy calves and its spread to animal attendants : case report

1998 ◽  
Vol 69 (4) ◽  
Author(s):  
J.K. Wabacha ◽  
G.K. Gitau ◽  
L.C. Bebora ◽  
C.O. Bwanga ◽  
Z.M. Wamuri ◽  
...  
Keyword(s):  
Case Report ◽  
Topical Treatment ◽  
Skin Lesions ◽  
Dairy Calves ◽  
Response To Treatment ◽  
Trichophyton Verrucosum ◽  
Dairy Animals ◽  
Hairless Skin ◽  
Anti Fungal ◽  
Head Neck

Persistent dermatomycosis (ringworm) caused by Trichophyton verrucosum affected 20 dairy calves aged between 3 months and 1 year and housed together. The infection also spread to 2 animal attendants working among the calves. The major clinical lesions observed on the affected calves were extensive alopecia and/or circumscribed thick hairless skin patches affecting the head, neck, flanks and limbs. The observed lesions persisted for more than 17 weeks and most of the calves did not respond to topical treatment with various anti-fungal drugs within the anticipated period of 9 weeks. Two animal attendants developed skin lesions that were circumscribed and itchy and there was good response to treatment following the application of anti-fungal skin ointment. Although ringworm in dairy animals in Kenya has not previously been associated with spread to humans, the potential is evident from this report.

scholarly journals Case report on tuberous sclerosis

2021 ◽  
Vol 97 (2) ◽  
pp. 56-60
Author(s):  
Nadezhda V. Krasnova ◽  
Geliya G. Gimalieva ◽  
Larisa G. Sinitsyna
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Ct Scan ◽  
Tuberous Sclerosis ◽  
Skin Lesions ◽  
Visual Examination ◽  
Comprehensive Examination ◽  
The Face ◽  
The Brain ◽  
Tubular Bones

Patient M., 23 years old, consulted a dermatologist with complaints of rashes on the face, which had bothered since childhood. On objective examination, skin lesions were widespread. A visual examination revealed spots of hypopigmentation, angiofibromas of the face, shagreen fate of the skin, periungual fibromas. She was diagnosed with tuberous sclerosis. Further examination revealed a neoplasm in the brain and right kidney, damage to the lungs, tubular bones, lymphadenopathy. The patient continues to be monitored by a neurologist and therapist. Based on the results of CT scan of the chest organs, an oncologist's consultation was scheduled to conduct an oncology search. Thus, with skin manifestations characteristic of this disease, it is necessary to conduct a comprehensive examination to identify concomitant pathology and early diagnosis of complications.

scholarly journals Acute Fulminant Necrotizing Amoebic Colitis: A potentially fatal cause of diarrhoea on the Acute Medical Unit

2011 ◽  
Vol 10 (3) ◽  
pp. 145-148
Author(s):  
Purav Desai ◽  
◽  
Nurani Sivaramakrishnan ◽  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
High Mortality ◽  
Travel History ◽  
Medical Unit ◽  
Amebic Colitis ◽  
Acute Medical Unit ◽  
Amoebic Colitis

Abstract Diarrhoea is a common presenting complaint to the Acute Medical Unit. We report a case of acute fulminant necrotizing amebic colitis in a 73 year old man with no recent travel history preceding his admission. Such cases are often difficult to diagnose and hence associated with a high mortality, unless treated promptly and appropriately. This case report highlights the importance of early diagnosis and prompt initiation of treatment.

Drug eruption due to bupropion, a case report

2016 ◽  
Vol 33 (S1) ◽  
pp. S619-S620 ◽  
Author(s):  
N. Salgado ◽  
S. Benavente ◽  
J.M. Coll ◽  
A. Vives
Keyword(s):  
Case Report ◽  
Food Additives ◽  
Skin Lesions ◽  
Acute Onset ◽  
Diagnostic Features ◽  
Inflammatory Drugs ◽  
Competing Interest ◽  
Antidepressive Medication ◽  
Diagnostic Criterion

IntroductionWe present a clinical case of eruption caused by the use of bupropion. Bupropion is known to cause hypersensitivity reactions.Case reportWe report the case of a 48-year-old female who was diagnosed of depressive disorder. She went to emergency because a few days after prescribing bupropion (150 mg/24 h) scaly skin eruptions were found distributed along the skin. In the present case, after its introduction, bupropion was found to be a probable etiological agent. The patient was successfully treated with corticosteroids. Because of that, bupropion dosage was stopped and replaced with fluoxetine. No remissions and exacerbations were noticed in a month's follow up.DiscussionIn this case report, we present a patient with an eruption related to bupropion. The aetiological spectrum of eruption include drugs, infectious agents and food additives. Drugs attributing eruption include nonsteroidal anti-inflammatory drugs, antibiotics, and anti-epileptic drugs, antidepressive medication amongst others.ConclusionsNo specific diagnostic criterion exists for eruption and the diagnosis is purely based on clinical presentation. Diagnostic features, which suggest eruption, are the acute onset (or recurrent nature) and skin lesions.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Case report on tuberous sclerosis

2017 ◽  
Vol 6 (4) ◽  
pp. 997
Author(s):  
Zeebaish S. ◽  
Hemalatha P. ◽  
Anusha Y. ◽  
Surendra Reddy N. ◽  
Durga Prasad T. S.
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Tuberous Sclerosis ◽  
Female Child ◽  
Skin Lesions ◽  
Multisystem Disorder ◽  
Three Generations ◽  
Pigmented Skin Lesions ◽  
The Brain

Tuberous sclerosis is a genetic multisystem disorder characterized by widespread hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung and liver.  The affected genes are TSC1 and TSC2, encoding hamartin and tuberin respectively.  Most features of tuberous sclerosis become evident only in childhood, limiting their usefulness for early diagnosis. We report a case of 3months old female child with seizures and hypo-pigmented skin lesions. The case is rare as it is documented in a family affected continuously in three generations involving four members.

scholarly journals Superficial Cutaneous Zygomycosis Presenting as Resistant Intertrigo: A Case Report

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Devon E McMahon ◽  
Kristen Hysell ◽  
Mary Montgomery ◽  
Jason Frangos
Keyword(s):  
Case Report ◽  
Mortality Rate ◽  
Fungal Infection ◽  
High Mortality ◽  
Unusual Case ◽  
Immunocompromised Host ◽  
Mucor Circinelloides

Abstract Zygomycosis is an angioinvasive fungal infection with a high mortality rate. Cutaneous zygomycosis is the second most common form of the disease, typically characterized by necrotic eschars in an immunocompromised host. We report an unusual case of superficial intertrigo resistant to conventional therapies caused by Mucor circinelloides in a patient with HIV and diabetes.

scholarly journals Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challenging Experience and Review

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Dina Sameh Soliman ◽  
Ahmad Al-Sabbagh ◽  
Feryal Ibrahim ◽  
Amna Gameil ◽  
Mohamed Yassin ◽  
...  
Keyword(s):  
Mast Cell ◽  
Case Report ◽  
T Cell ◽  
Mast Cells ◽  
Systemic Mastocytosis ◽  
Peripheral Blood Smear ◽  
Skin Lesions ◽  
Acute Onset ◽  
Cell Leukaemia ◽  
First Case

Background. Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging. This is due to its heterogeneity in clinical presentations and cytomorphological and immunophenotypical features together with potential associations with other hematologic neoplasms which can complicate the condition and delay accurate diagnosis. To the best of our knowledge, this is the first case report of CD4-positive mast cell leukaemia. Case Presentation. A 39-year-old male presented with acute onset of fever, abdominal pain, and generalized body aches of two-week duration. Peripheral blood smear showed circulating blasts (13%) with coarsely basophilic granulation. Bone marrow (BM) aspirate showed extensive infiltration with immature mast cells of blast-like morphology with trilineage dysplasia and evident hemophagocytic activity exhibited by histiocytes and neoplastic mast cells. BM biopsy was diffusely infiltrated with many atypical mast cells positive for CD45, CD117, mast cell tryptase, CD25, and CD4 with partial positivity for CD7 and CD30. Cytogenetics showed an abnormal karyotype: 47, XY, +1947, XY, +19[13]/46, XY[9]. Molecular analysis revealed a KIT D816V mutation consistent with a diagnosis of systemic mastocytosis, mast cell leukaemia. Conclusion. The expression of T-cell associated markers by abnormal mast cells is well documented; however, CD4 and CD7 expression have not previously been described in association with mast cell leukaemia. Coexpression of CD2, CD4, CD7, and CD30 by the mast cells particularly in skin lesions may provoke misinterpretation as a cutaneous T-cell neoplasm. To the best of our knowledge, this is the first report of CD4-positive mast cell leukaemia. Moreover, hemophagocytic mast cell leukaemia is a very rare morphologic variant, and possible correlation between this finding and expression of CD4 by neoplastic mast cells is a topic for further investigation.

scholarly journals Morbilliform rashes in a patient with COVID-19 infection: A case report

2021 ◽  
Vol 59 (236) ◽  
Author(s):  
Kiran Ghimire ◽  
Nabin Adhikari
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Skin Lesions ◽  
Low Grade ◽  
Cytokine Storm ◽  
Skin Manifestation ◽  
Poor Countries ◽  
Immune Mediated ◽  
Resource Poor ◽  
Common Skin

As the current COVID-19 pandemic is evolving, skin lesions are being reported more, the most common skin manifestation being morbilliform rashes. We describe a patient of severe COVID-19 infection, 48-year-old who initially presented with fever, cough and constitutional symptoms who developed morbilliform macular rashes during his illness. The rash appeared on 6th day of illness in the trunk, arms with sparing of palms and soles, associated with itching. He later developed features of the cytokine-storm syndrome. The exact mechanism for the rashes is yet to be elaborated, however, it is postulated that it is either due to immune-mediated vasodilation or micro thrombosis secondary to low-grade-coagulopathy associated with COVID-19. Recognition of rashes as a feature of this disease is particularly significant to clinicians as it aids in early diagnosis, particularly in resource-poor countries. There is no evident association, however, between the severity and the rashes in COVID-19 infection.

scholarly journals Encephalopathy an Atypical Presentation of Intussusception: A Case Report

2020 ◽  
Vol 8 (1) ◽  
pp. 41-44
Author(s):  
Venma Mampilly ◽  
Sasikumar Manalumukkil Sankaran ◽  
Ramaraj Subbiah
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Early Diagnosis ◽  
Pediatric Emergency ◽  
Acute Onset ◽  
Differential Diagnoses ◽  
Atypical Presentation ◽  
Neurological Manifestations ◽  
Abdominal Symptoms

Background: Intussusception Encephalopathy is a pediatric emergency where a stuporous child presents with or without abdominal symptoms. Neurological manifestations of intussusception are an atypical presentation of this condition. It often misleads clinicians to other differential diagnoses of encephalopathy. The Case: We present to you a case of an 11-month-old child presented with encephalopathy, acute in onset with underlying intussusception. Conclusion: Intussusception encephalopathy is a pediatric emergency. It should be kept as a differential diagnosis when a child presents with complaints of acute onset of drowsiness with or without abdominal symptoms. Early diagnosis could save grave complications and improve the prognosis.

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