Can long-term antibiotic treatment prevent progression of peripheral arterial occlusive disease? A large, randomized, double-blinded, placebo-controlled trial

2008 ◽  
Vol 196 (2) ◽  
pp. 937-942 ◽  
Author(s):  
J.B. Joensen ◽  
S. Juul ◽  
E. Henneberg ◽  
G. Thomsen ◽  
L. Ostergaard ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Peripheral Arterial Occlusive Disease ◽  
Controlled Trial ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Peripheral Arterial ◽  
Double Blinded

Variability of non-response to aspirin in patients with peripheral arterial occlusive disease during long-term follow-up

2009 ◽  
Vol 88 (10) ◽  
pp. 979-988 ◽  
Author(s):  
Birgit Linnemann ◽  
Stephanie Prochnow ◽  
Helen Mani ◽  
Jan Schwonberg ◽  
Edelgard Lindhoff-Last
Keyword(s):  
Peripheral Arterial Occlusive Disease ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Long Term Follow Up ◽  
Peripheral Arterial

scholarly journals A retrospective cohort study on the provision and outcomes of pharmacological therapy after revascularisation for peripheral arterial occlusive disease: a study protocol

2020 ◽  
Vol 2 (1) ◽  
pp. e000020 ◽  
Author(s):  
Frederik Peters ◽  
Thea Kreutzburg ◽  
Jenny Kuchenbecker ◽  
Sebastian Debus ◽  
Ursula Marschall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Insurance ◽  
Peripheral Arterial Occlusive Disease ◽  
Pharmacological Therapy ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Insurance Fund ◽  
Long Term Outcomes ◽  
Peripheral Arterial

BackgroundSymptomatic peripheral arterial occlusive disease (PAOD) involves highly complex and costly revascularisations for preventing adverse limb events and impaired survival. Contrary to recommendations from valid guidelines, a large group of patients do not receive adequate pharmacological therapy after such interventions. Based on health insurance claims data, our study aims to assess (1) the extent of provision of pharmacological therapy after revascularisation and (2) related long-term outcomes for all patients and subgroups, that is, gender and disease severity.MethodsA retrospective observational population-based cohort study will be based on data from the second largest statutory health insurance fund in Germany (BARMER) covering about 13% of the insured population (~10 million patients). Study entry is the index revascularisation for symptomatic PAOD. Study variables will be analysed and compared among subgroups using parametric and non-parametric tests, generalised linear regression analysis and survival models.DiscussionThis study will provide a comprehensive insight in the extent and time trends of adequate provision of pharmacological therapy and long-term outcomes for patients with symptomatic PAOD. This may help to identify those patients benefiting most from improved pharmacological therapy for increasing the success of revascularisations in general.Trial registrationNCT03909022.

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