Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina pectoris

2010 ◽  
Vol 213 (2) ◽  
pp. 482-485 ◽  
Author(s):  
Tian Feng ◽  
Chen Yundai ◽  
Chen Lian ◽  
Sun Zhijun ◽  
Liu Changfu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Coronary Plaque ◽  
Unstable Angina Pectoris ◽  
Optical Coherence ◽  
Patients With Diabetes

scholarly journals CLINICAL PRESENTATION AND PLAQUE MORPHOLOGY IN UNSTABLE ANGINA PECTORIS: AN OPTICAL COHERENCE TOMOGRAPHY STUDY

2010 ◽  
Vol 55 (10) ◽  
pp. A112.E1050
Author(s):  
Masato Mizukoshi ◽  
Takashi Kubo ◽  
Atsushi Tanaka ◽  
Shigeho Takarada ◽  
Hironori Kitabata ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Clinical Presentation ◽  
Unstable Angina Pectoris ◽  
Plaque Morphology ◽  
Optical Coherence

scholarly journals Intracoronary Imaging in the Management of a Complex and Recurrent Acute Coronary Syndrome Associated With Multiple Comorbidities. A Case Report

2017 ◽  
Vol 3 (2) ◽  
pp. 94-98
Author(s):  
Ioana Rodean ◽  
Elisabeta Himcinschi ◽  
Alexandra Tirca ◽  
Daniel Cernica
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris ◽  
Atheromatous Plaque ◽  
Optical Coherence ◽  
Plaque Vulnerability ◽  
Intracoronary Imaging ◽  
Coronary Syndrome

Abstract Coronary artery disease represents a major cause of morbidity and mortality around the world. Unstable angina pectoris is a serious manifestation of ischemic heart disease and represents an acute condition caused by the narrowing of the coronary lumen as the result of an atheromatous plaque formation. In most cases the trigger of this process is represented by the rupture of a plaque that has become vulnerable or unstable. The first-line intracoronary imaging technique for the evaluation of plaque vulnerability is optical coherence tomography, which can measure the thickness of the fibrous cap (a significant predictor of plaque vulnerability) and can also assess other characteristics of plaque vulnerability (macrophage infiltration, lipid pool, intracoronary thrombus, or neointimal rupture). We present the case of a 67-year-old male with symptoms suggestive of unstable angina pectoris, caused by the presence of a vulnerable plaque on the left main coronary artery, where optical coherence tomography had a significant contribution in identifying the etiology of chest pain.

scholarly journals CD4+/CD8+ ratio positively correlates with coronary plaque instability in unstable angina pectoris patients but fails to predict major adverse cardiovascular events

2020 ◽  
Vol 11 ◽  
pp. 204062232092202
Author(s):  
Dayang Chai ◽  
Xiangquan Kong ◽  
Shu Lu ◽  
Junjie Zhang
Keyword(s):  
Logistic Regression ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Binary Logistic Regression ◽  
Coronary Plaque ◽  
Unstable Angina Pectoris ◽  
Unstable Plaque ◽  
Plaque Instability ◽  
All Cause Mortality ◽  
Stable Plaque

Background: The association between CD4+/CD8+ ratio and coronary plaque instability in patients with unstable angina pectoris (UAP) has not been investigated. We sought to elucidate the correlation between CD4+/CD8+ ratio and plaque instability in this patient population. Methods: We enrolled 266 UAP patients who underwent pre-intervention optical coherence tomography (OCT) examination and percutaneous coronary intervention in our center from January 2016 to January 2018. Features of coronary plaques in the culprit arteries were classified as unstable plaque and stable plaque. Primary endpoint was occurrence of a major adverse cardiovascular event (MACE). Receiver operating characteristic (ROC) analyses were used to determine the predictive efficacy of the CD4+/CD8+ ratio for a group of unstable plaque patients, and binary logistic regression analysis was performed to evaluate potential independent predictors of plaque instability. All-cause mortality and MACE between the two groups were analyzed. Results: UAP patients with unstable plaque had a higher CD4/CD8 ratio compared with stable plaque patients ( p < 0.05). Results of binary logistic regression analyses showed that CD4+/CD8+ ratio ⩾1.725 and prior stroke were predictors and risk factors of plaque instability ( p < 0.05). ROC analyses showed that CD4+/CD8+ ratio ⩾1.725 was predictive of plaque instability in UAP patients. However, the Kaplan–Meier estimate for MACE and all-cause mortality showed no statistical significance. Conclusions: Higher CD4+/CD8+ ratio is associated with higher risk of plaque instability in our cohort of UAP patients. However, CD4+/CD8+ ratio was not an independent predictor of 1-year MACE or all-cause mortality.

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