Adenosine A2A Receptor Agonist Improves Cardiac Dysfunction From Pulmonary Ischemia-Reperfusion Injury

2005 ◽  
Vol 79 (4) ◽  
pp. 1189-1195 ◽  
Author(s):  
T. Brett Reece ◽  
Victor E. Laubach ◽  
Curtis G. Tribble ◽  
Thomas S. Maxey ◽  
Peter I. Ellman ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cardiac Dysfunction ◽  
Receptor Agonist ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Pulmonary Ischemia

Effect of adenosine A2A receptor agonist (CGS) on ischemia/reperfusion injury in isolated rat liver

APOPTOSIS ◽  
2005 ◽  
Vol 10 (5) ◽  
pp. 955-962 ◽  
Author(s):  
Z. Ben-Ari ◽  
O. Pappo ◽  
J. Sulkes ◽  
Y. Cheporko ◽  
B. A. Vidne ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Liver ◽  
Receptor Agonist ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adenosine A2a Receptor ◽  
Isolated Rat Liver ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Isolated Rat

scholarly journals Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia–reperfusion injury

2010 ◽  
Vol 139 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Ashish K. Sharma ◽  
Victor E. Laubach ◽  
Susan I. Ramos ◽  
Yunge Zhao ◽  
George Stukenborg ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model

2011 ◽  
Vol 142 (4) ◽  
pp. 887-894 ◽  
Author(s):  
Damien J. LaPar ◽  
Victor E. Laubach ◽  
Abbas Emaminia ◽  
Ivan K. Crosby ◽  
Vanessa A. Hajzus ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Reperfusion Injury ◽  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Transplantation Model

scholarly journals Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation

2020 ◽  
Vol 21 (18) ◽  
pp. 6747
Author(s):  
Zoltan Czigany ◽  
Eve Christiana Craigie ◽  
Georg Lurje ◽  
Shaowei Song ◽  
Kei Yonezawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Adenosine A2a Receptor ◽  
Large Animal Model ◽  
Large Animal ◽  
Receptor Stimulation ◽  
A2a Receptor ◽  
Htk Solution ◽  
Adenosine A2a

Orthotopic liver transplantation (OLT) using allografts from donation after circulatory death (DCD) is potentially associated with compromised clinical outcomes due to ischemia-reperfusion injury (IRI)-induced organ damage and graft-related complications. The aim of this study was to provide in vivo data on the effects of adenosine A2a receptor stimulation in a clinically relevant large animal model of DCD liver transplantation. Cardiac arrest was induced in German Landrace pigs (n = 10; 20–25 kg). After 30 min of warm ischemia, the donor liver was retrieved following a cold flush with 3 L of histidine-tryptophan-ketoglutarate-HTK solution. Animals of the treatment group (n = 5/group) received a standard dose of the selective adenosine receptor agonist CGS 21680 added to the cold flush. All grafts were stored for 4.5 h at 4 °C in HTK-solution before OLT. Hepatocellular injury, apoptosis, protein kinase A-PKA activity, graft microcirculation, liver function, and animal survival were assessed. Compared to untreated livers, adenosine A2a receptor stimulation resulted in improved tissue microcirculation (103% ± 5% vs. 38% ± 4% compared to baseline; p < 0.05), accelerated functional recovery of the graft (indocyanine green-plasma disappearance rate (ICG-PDR) of 75% ± 18% vs. 40% ± 30% after 3 h), increased PKA activity ratio (56% ± 3% vs. 32% ± 3%; p < 0.001 after 1 h), and consequently reduced tissue necrosis and apoptosis. The potent protective effects were clinically manifested in significantly improved survival in the treatment group after 72 h (100% vs. 40%; p = 0.04). The ex vivo administration of adenosine A2a receptor agonist during the back-table flush mitigates IRI-mediated tissue damage and improves functional graft recovery and survival in a large animal model of DCD liver transplantation.

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