Benign Metastasizing Leiomyoma: A Rare Cause of Multiple Pulmonary Nodules

2012 ◽  
Vol 93 (6) ◽  
pp. e149-e151 ◽  
Author(s):  
Aparna S. Rege ◽  
Justin A. Snyder ◽  
Walter J. Scott
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Multiple Pulmonary Nodules ◽  
Metastasizing Leiomyoma

scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

scholarly journals Benign Metastatic Leiomyoma Presenting as a Hemothorax

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Anna M. Ponea ◽  
Creticus P. Marak ◽  
Harmeen Goraya ◽  
Achuta K. Guddati
Keyword(s):  
Bone Marrow ◽  
Respiratory Failure ◽  
Hormonal Therapy ◽  
Skeletal Muscles ◽  
Pulmonary Nodules ◽  
Immunohistochemical Analysis ◽  
Lung Parenchyma ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

Pulmonary Benign Metastasizing Leiomyoma, a Rare Cause of Pulmonary Nodules

2016 ◽  
Vol 52 (4) ◽  
pp. 226-227
Author(s):  
Patricia Pérez-Ferrer ◽  
Eusebi Chiner ◽  
José Norberto Sancho-Chust ◽  
Mar Arlandis
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals AB027. Benign metastasizing leiomyoma: a rare cause of diffuse pulmonary nodules

2017 ◽  
Vol 9 (S14) ◽  
pp. AB027-AB027
Author(s):  
Yu Chen ◽  
Hung-I Lu ◽  
Chien-Ming Lo ◽  
Ming-Jang Hsie
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Benign Metastasizing Leiomyoma-An Unusual Cause of Diffuse Pulmonary Nodules

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 989S
Author(s):  
Lena S. Avedissian ◽  
Oleh W. Hnatiuk ◽  
Douglas S. Frenia
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals Incidental Benign Metastasizing Leiomyoma in a Patient with Bone Sarcoma: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Zanndor Jacob del Real-Romo ◽  
Carlos Montero-Cantú ◽  
Oscar Villegas-Cabello ◽  
José Antonio Díaz-Elizondo ◽  
Danae Reyes-Salas ◽  
...  
Keyword(s):  
Ct Scan ◽  
Pulmonary Nodules ◽  
Rare Condition ◽  
Bone Sarcoma ◽  
Conservative Surgery ◽  
Left Knee ◽  
Pathology Report ◽  
Benign Metastasizing Leiomyoma ◽  
History Of ◽  
Metastasizing Leiomyoma

Background. The benign metastasizing leiomyoma is an exceptionally rare entity; it presents with ectopic leiomyoma nodules with a benign pattern. Symptoms vary according to the anatomic location. The diagnosis is histopathological, usually in patients with history of hysterectomy.Case Presentation. A 36-year-old female with 2-month history of left knee pain was diagnosed with bone fibrosarcoma. A CT scan showed pulmonary nodules. The patient started neoadjuvant chemotherapy. Conservative surgery of pelvic limb was achieved. A new CT scan reported pulmonary nodules that remained in relation to the previous CT. A nodule resection by thoracotomy and TOB (transoperative biopsy) was performed. The final pathology report described benign proliferative lesions consistent with benign metastatic leiomyoma.Conclusions. Benign metastatic leiomyoma is a rare condition presenting with uterine and extrauterine nodules most commonly in the lung. The diagnosis is histopathological. The surgical procedure must be reserved for selected patients.

scholarly journals Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Yeong Hun Choe ◽  
So Yeon Jeon ◽  
Yoon Chae Lee ◽  
Myung Ja Chung ◽  
Seung Yong Park ◽  
...  
Keyword(s):  
Case Report ◽  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma
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