scholarly journals Incidental Benign Metastasizing Leiomyoma in a Patient with Bone Sarcoma: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Zanndor Jacob del Real-Romo ◽  
Carlos Montero-Cantú ◽  
Oscar Villegas-Cabello ◽  
José Antonio Díaz-Elizondo ◽  
Danae Reyes-Salas ◽  
...  
Keyword(s):  
Ct Scan ◽  
Pulmonary Nodules ◽  
Rare Condition ◽  
Bone Sarcoma ◽  
Conservative Surgery ◽  
Left Knee ◽  
Pathology Report ◽  
Benign Metastasizing Leiomyoma ◽  
History Of ◽  
Metastasizing Leiomyoma

Background. The benign metastasizing leiomyoma is an exceptionally rare entity; it presents with ectopic leiomyoma nodules with a benign pattern. Symptoms vary according to the anatomic location. The diagnosis is histopathological, usually in patients with history of hysterectomy.Case Presentation. A 36-year-old female with 2-month history of left knee pain was diagnosed with bone fibrosarcoma. A CT scan showed pulmonary nodules. The patient started neoadjuvant chemotherapy. Conservative surgery of pelvic limb was achieved. A new CT scan reported pulmonary nodules that remained in relation to the previous CT. A nodule resection by thoracotomy and TOB (transoperative biopsy) was performed. The final pathology report described benign proliferative lesions consistent with benign metastatic leiomyoma.Conclusions. Benign metastatic leiomyoma is a rare condition presenting with uterine and extrauterine nodules most commonly in the lung. The diagnosis is histopathological. The surgical procedure must be reserved for selected patients.

scholarly journals Benign metastasizing leiomyoma – a case of benign metastasis

JRSM Open ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 205427042110644
Author(s):  
Diogo André ◽  
Fabiana Gouveia ◽  
Helena Luís ◽  
Mónica Caldeira ◽  
Filipe Perneta ◽  
...  
Keyword(s):  
Abdominal Mass ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Pulmonary Nodules ◽  
Rare Condition ◽  
Childbearing Age ◽  
History Of ◽  
Metastasizing Leiomyoma ◽  
Benign Tumours ◽  
Abdominal Lesions

Leiomyomas are benign tumours of smooth muscle cells that most often affect the female genital tract, but their metastasis to extra-uterine locations represent rare, yet misunderstood phenomena. The authors present a clinical case of a 42-year-old woman, who underwent a hysterectomy 15 years ago due to myomas, admitted with multiple pulmonary nodules and abdominal mass, diagnosed by imaging tests, in the context of haemoptysis. The anatomopathological exams of the pulmonary and abdominal lesions were compatible with the diagnosis of benign metastatic leiomyoma. Benign metastatic leiomyoma is a rare condition that particularly affects women of childbearing age, with a history of hysterectomy for uterine fibroids. Hence, this entity must be considered in the differential diagnosis of women with pulmonary nodules of uncertain aetiology.

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Parikshit Padhi ◽  
Margarita Topalovski
Keyword(s):  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Rare Condition ◽  
Middle Aged ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cell Neoplasm ◽  
Aged Woman ◽  
History Of ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

Benign metastasizing leiomyoma (BML) is a rare spindle cell neoplasm seen in middle-aged women who have a history of leiomyoma of the uterus. The most common sites of metastases are the lungs; however, other sites of spread have been documented. These tumors by definition have no malignant features on histology and tend to be estrogen and progesterone positive. We present a middle-aged woman who was incidentally found to have multiple pulmonary nodules and a mass on her sternum after she was involved in a motor vehicle accident. She had a history of uterine leiomyoma and had undergone a hysterectomy ten years prior to the accident. Biopsies were performed of the lung nodules and sternum mass and compared to her hysterectomy specimen, and they were identical, and hence, she was diagnosed with BML. Due to the growing tumor of her sternum, she was started on tamoxifen with stability of her tumors. These tumors, since they are benign, tend to have an indolent course. However, in the instances that treatment is warranted, options include surgery or antiestrogen therapy. We will be discussing the pathogenesis, histological findings, and treatment options of this rare condition. Our case is unique because BML in general do not tend to spread to multiple organs and tend to be limited to one site of disease.

scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

scholarly journals Benign Metastatic Leiomyoma Presenting as a Hemothorax

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Anna M. Ponea ◽  
Creticus P. Marak ◽  
Harmeen Goraya ◽  
Achuta K. Guddati
Keyword(s):  
Bone Marrow ◽  
Respiratory Failure ◽  
Hormonal Therapy ◽  
Skeletal Muscles ◽  
Pulmonary Nodules ◽  
Immunohistochemical Analysis ◽  
Lung Parenchyma ◽  
Molecular Profiling ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Uterine leiomyomas have been reported to metastasize to various organs including the lungs, skeletal muscles, bone marrow, peritoneum, and heart. They may present with symptoms related to the metastases several years after hysterectomy. These tumors regress after menopause, and it is rare to detect active tumors in postmenopausal women. Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia. Pulmonary benign metastasizing leiomyoma is usually detected in the form of pulmonary nodules incidentally on imaging. Tissue biopsy of these nodules is required to identify them as benign metastasizing leiomyomas. Immunohistochemical analysis and molecular profiling may further help detect any malignant transformation in it. Untreated pulmonary benign metastasizing leiomyoma may result in the formation of cystic structures, destruction of lung parenchyma, and hemothorax and may cause respiratory failure. Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure.

Spontaneous atraumatic knee haemarthrosis

2020 ◽  
Vol 13 (10) ◽  
pp. e236362
Author(s):  
Sefa William Canbilen ◽  
Khaldoun El Abed ◽  
Riaz Ahmad
Keyword(s):  
Weight Bearing ◽  
Lateral Meniscus ◽  
Rare Condition ◽  
The Elderly ◽  
Lateral Compartment ◽  
Left Knee ◽  
Posterior Horn ◽  
Peripheral Arteries ◽  
Lateral Meniscectomy ◽  
History Of

Spontaneous knee haemarthrosis is a rare condition, most prevalent in the elderly with osteoarthritis. Recent reports have proposed that the source of bleeding is the peripheral arteries supplying the posterior horn of the lateral meniscus. In this case, a 62-year-old active man presented with acute postero-lateral left knee pain and swelling with limited weight bearing or movement of the knee. No recent history of trauma but history of lateral compartment dominant osteoarthritis and arthroscopic partial lateral meniscectomy of left knee. Aspiration showed a large haemarthrosis and following an MRI scan displaying large areas of full thickness chondral loss, complex tearing of lateral meniscus and loose bodies, the patient had an arthroscopy, washout, debridement of osteochondral tibial defect and diathermy of suspected bleeding point. This report supports the peripheral arteries supplying the posterior horn of the lateral meniscus as the source of bleeding in spontaneous haemarthrosis of the knee.

Pulmonary Benign Metastasizing Leiomyoma, a Rare Cause of Pulmonary Nodules

2016 ◽  
Vol 52 (4) ◽  
pp. 226-227
Author(s):  
Patricia Pérez-Ferrer ◽  
Eusebi Chiner ◽  
José Norberto Sancho-Chust ◽  
Mar Arlandis
Keyword(s):  
Pulmonary Nodules ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals A Disorder Easy to be Misdiagnosed--benign Metastasizing Uterine Leiomyoma with Multiple Metastasis to Lungs and Pelvic Lymph Nodes Simultaneously and Literature Review

2021 ◽  
Author(s):  
tong tong ◽  
Qiong Fan ◽  
Yudong Wang ◽  
Yuhong Li
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Skeletal Muscles ◽  
Left Renal Vein ◽  
Uterine Sarcoma ◽  
Bilateral Oophorectomy ◽  
Benign Metastasizing Leiomyoma ◽  
History Of ◽  
Benign Nature ◽  
Metastasizing Leiomyoma

Abstract Background: Benign metastasizing leiomyoma (BML) is a rare disease that is usually seen in females of reproductive or premenopausal age with a previous surgery history of uterine myomectomy or hysterectomy. The most common sites of metastases are pulmonary metastases, and other sites include heart, bones, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, and central nervous system. Here we report a case of 50-year-old women with history of hysterectomy whom was first suspect uterine sarcoma but finally confirmed BML with lung and lymph node metastases at the same time and discuss the treatment and prognosis of BML. Case presentation: A 50-year-old women who have a history of abdominal total hysterectomy presented with mild but persistent abdominal pain for over 3 months. She was suspected uterine sarcoma before surgery and laparoscopic extensive debulking surgery including bilateral oophorectomy, pelvic and para-aortic lymph node dissection to the level of the left renal vein, and right inguinal lymph nodes dissection trans-cutaneously were done. Pathology after surgery confirmed benign leiomyoma and she was diagnosed BML. No medicine was given after the surgery and now the follow up is of no significance. Conclusions: Benign metastasizing leiomyoma (BML) is a rare disorder in which histologically benign smooth muscle tumor metastasize to extra-uterine sites. Metastases are commonly seen in the lung, liver, lymph nodes, skin, bladder, esophagus, skeletal muscles, et al. BML is usually misdiagnosed as malignant tumor before surgery until pathology confirmed the benign nature. The treatment is controversial and undetermined. The prognosis is usually favorable because of its benign nature.

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