Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides

2006 ◽  
Vol 1761 (9) ◽  
pp. 1070-1077 ◽  
Author(s):  
Jessica Lie ◽  
Matthijs Moerland ◽  
Teus van Gent ◽  
Rien van Haperen ◽  
Leo Scheek ◽  
...  
Keyword(s):  
Sex Differences ◽  
High Density ◽  
High Density Lipoproteins ◽  
Phospholipid Transfer Protein ◽  
Protein Activity ◽  
Transfer Protein ◽  
Phospholipid Transfer ◽  
Plasma High Density

scholarly journals Phospholipid transfer protein activity in two cholestatic patients

2004 ◽  
Vol 122 (4) ◽  
pp. 175-177 ◽  
Author(s):  
Eliana Cotta de Faria ◽  
Adriana Celeste Gebrin ◽  
Wilson Nadruz Júnior ◽  
Lucia Nassi Castilho
Keyword(s):  
Density Lipoprotein ◽  
Plasma Phospholipid ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Phospholipid Transfer Protein ◽  
Low Density ◽  
Protein Activity ◽  
Transfer Protein ◽  
Phospholipid Transfer

CONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes a net movement of phospholipids, thereby generating small lipid-poor apolipoprotein AI that contains particles and subfractions that are good acceptors for cell cholesterol efflux. CASE REPORT: We measured the activity of plasma phospholipid transfer protein in two cholestatic patients, assuming that changes in activity would occur in serum that was positive for lipoprotein X. Both patients presented severe hypercholesterolemia, high levels of low density lipoprotein cholesterol and, in one case, low levels of high density lipoprotein cholesterol and high levels of phospholipid serum. The phospholipid transfer activity was close to the lower limit of the reference interval. To our knowledge, this is the first time such results have been presented. We propose that phospholipid transfer protein activity becomes reduced under cholestasis conditions because of changes in the chemical composition of high density lipoproteins, such as an increase in phospholipids content. Also, lipoprotein X, which is rich in phospholipids, could compete with high density lipoproteins as a substrate for phospholipid transfer protein.

Plasma phospholipid transfer protein and the anti-atherogenic potential of high density lipoproteins

2000 ◽  
Vol 151 (1) ◽  
pp. 182
Author(s):  
A. Van Tol ◽  
P.S. Vermeulen ◽  
M. Jauhiainen ◽  
R. Van Haperen ◽  
T. Van Gent ◽  
...  
Keyword(s):  
Plasma Phospholipid ◽  
High Density ◽  
High Density Lipoproteins ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals The Mechanism of the Remodeling of High Density Lipoproteins by Phospholipid Transfer Protein

2001 ◽  
Vol 276 (29) ◽  
pp. 26898-26905 ◽  
Author(s):  
Nongnuch Settasatian ◽  
MyNgan Duong ◽  
Linda K. Curtiss ◽  
Christian Ehnholm ◽  
Matti Jauhiainen ◽  
...  
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
Phospholipid Transfer Protein ◽  
Transfer Protein ◽  
Phospholipid Transfer
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