Genes involved in phosphatidylcholine biosynthesis correlate with nuclear factor-κB in biliary tract cancer patients: Evidence from 1H NMR and computational analyses

2021 ◽  
pp. 158970
Author(s):  
Anusmita Shekher ◽  
Amit Kumar Tiwari ◽  
Nikee Awasthee ◽  
Sumit Singh Verma ◽  
Vinod Kumar Dixit ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
1H Nmr ◽  
Biliary Tract Cancer ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Tract Cancer ◽  
Phosphatidylcholine Biosynthesis ◽  
Computational Analyses

scholarly journals CA19-9 or CEA Decline after the First Cycle of Treatment Predicts Survival in Advanced Biliary Tract Cancer Patients Treated with S-1 and Cisplatin Chemotherapy

2017 ◽  
Vol 49 (3) ◽  
pp. 807-815 ◽  
Author(s):  
Dae-Won Lee ◽  
Seock-Ah Im ◽  
Yu Jung Kim ◽  
Yaewon Yang ◽  
Jiyoung Rhee ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Tract Cancer

scholarly journals Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients

2015 ◽  
Vol 3 (3) ◽  
pp. 464-470 ◽  
Author(s):  
HIDEO SUZUKI ◽  
JUAN C. ROA ◽  
TORU KAWAMOTO ◽  
KAZUNORI ISHIGE ◽  
IGNACIO I. WISTUBA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Insulin Like Growth Factor ◽  
Tract Cancer ◽  
Factor I ◽  
Growth Factor I

scholarly journals Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization

Hepatology ◽  
1995 ◽  
Vol 21 (2) ◽  
pp. 434-439 ◽  
Author(s):  
Masato Nagino ◽  
Yuji Nimura ◽  
Junichi Kamiya ◽  
Satoshi Kondo ◽  
Katsuhiko Uesaka ◽  
...  
Keyword(s):  
Portal Vein ◽  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Portal Vein Embolization ◽  
Hepatic Lobe ◽  
Tract Cancer

LDH serum levels as prognostic and predictive factor in advanced biliary tract cancer patients treated with first-line chemotherapy.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 313-313
Author(s):  
Luca Faloppi ◽  
Michela Del Prete ◽  
Mario Scartozzi ◽  
Daniele Santini ◽  
Maristella Bianconi ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Serum Levels ◽  
First Line ◽  
Tract Cancer ◽  
Group A ◽  
Group B ◽  
Line Chemotherapy

313 Background: Previous data suggested that LDH serum levels may be associated with tumour hypoxia and VEGFA and VEGFR-1 over-expression. LDH may then represent an indirect marker of activated tumour neo-angiogenesis and worse prognosis in many tumour types. In our analysis, we analyzed the role of LDH serum levels in predicting clinical outcome for biliary tract cancer patients treated with first-line cisplatin and gemcitabine chemotherapy, to individuate a potentially reliable and easy to use marker for patients stratification. Methods: 71 advanced biliary tract cancer patients treated with cisplatin and gemcitabine in first-line chemotherapy were available for our analysis. For all patients, LDH values were collected within one month before treatment beginning. We chose the laboratory cut-off (Upper Normal Rate, UNR) as LDH cut-off value (450 U/l) and then we divided the patients into two groups (A and B, below and above the UNR respectively). Survival distribution was estimated by the Kaplan-Meier method. Disease control rate (DCR) was assessed with chi-square test. A significant level of 0.05 was chosen to assess the statistical significance. Results: Patients in group A (46 patients) and B (25 patients) proved homogeneous for all clinical characteristics analyzed. Median progression free survival (PFS) was 3.97 months and 1.8 months respectively in group A (patients with LDH level below the UNR) and in group B (patients with LDH level above the UNR), p=0.0064 (HR=2.07, 95%CI: 1.07-3.99). Median overall survival (OS) was 9.24 months and 2.55 months in group A and B respectively, p<0.0001 (HR=2.93; 95%CI: 1.37-6.27). DCR was 65% in group A vs. 21% in group B (p=0.004). Conclusions: Our observations seem to suggest a prognostic role of LDH in biliary tract cancer patients. Our findings showing an improved PFS and DCR in patients with low LDH serum levels also suggest a possible predictive role in patients treated with a cisplatin and gemcitabine regimen as first-line chemotherapy. After further confirmation in larger trial, these results may be relevant for a better patients stratification and selection.

Sign in / Sign up

Export Citation Format

Share Document