scholarly journals Biophysical characterization of the insertion of two potent antimicrobial peptides-Pin2 and its variant Pin2[GVG] in biological model membranes

2020 ◽  
Vol 1862 (2) ◽  
pp. 183105 ◽  
Author(s):  
Brandt Bertrand ◽  
Sathishkumar Munusamy ◽  
José-Francisco Espinosa-Romero ◽  
Gerardo Corzo ◽  
Iván Arenas Sosa ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Model Membranes ◽  
Biological Model ◽  
Biophysical Characterization

scholarly journals Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms

2020 ◽  
Vol 2 ◽  
Author(s):  
Aurélie H. Benfield ◽  
Sónia Troeira Henriques
Keyword(s):  
Antimicrobial Peptides ◽  
Physicochemical Properties ◽  
Broad Spectrum ◽  
Mode Of Action ◽  
Bacterial Pathogens ◽  
Model Membranes ◽  
Membrane Disruption ◽  
Attractive Alternative ◽  
Bacterial Cells

Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of-actions distinct from those used by current antibiotics. In general, antimicrobial peptides kill bacteria by either disrupting their membrane, or by entering inside bacterial cells to interact with intracellular components. Characterization of their mode-of-action is essential to improve their activity, avoid resistance in bacterial pathogens, and accelerate their use as therapeutics. Here we review experimental biophysical tools that can be employed with model membranes and bacterial cells to characterize the mode-of-action of antimicrobial peptides.

scholarly journals Biophysical Characterization Of Phosphatidyl Alcohols In Model Membranes- Effects Of Headgroup Size

2009 ◽  
Vol 96 (3) ◽  
pp. 459a
Author(s):  
Shishir Jaikishan ◽  
Anders Björkbom ◽  
J. Peter Slotte
Keyword(s):  
Model Membranes ◽  
Biophysical Characterization

scholarly journals Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis

2019 ◽  
Vol 1861 (6) ◽  
pp. 1213-1227 ◽  
Author(s):  
Ruchika Dadhich ◽  
Abhishek Singh ◽  
Anjana P. Menon ◽  
Manjari Mishra ◽  
C.D. Athul ◽  
...  
Keyword(s):  
Drug Screening ◽  
Model Membranes ◽  
Biophysical Characterization

Purification and Biophysical Characterization of an 11S Globulin from Wrightia tinctoria Exhibiting Hemagglutinating Activity

2013 ◽  
Vol 20 (5) ◽  
pp. 499-509 ◽  
Author(s):  
Pramod Kumar ◽  
Dipak N. Patil ◽  
Anshul Chaudhary ◽  
Shailly Tomar ◽  
Dinesh Yernool ◽  
...  
Keyword(s):  
Hemagglutinating Activity ◽  
Biophysical Characterization ◽  
11S Globulin ◽  
Wrightia Tinctoria

Biophysical Characterization of Glycodendrimers As Nano-carriers for HIV Peptides

2013 ◽  
Vol 20 (31) ◽  
pp. 3935-3943 ◽  
Author(s):  
M. Ionov ◽  
K. Ciepluch ◽  
B. Moreno ◽  
D. Appelhans ◽  
J. Sanchez-Nieves ◽  
...  
Keyword(s):  
Biophysical Characterization
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