scholarly journals The outstanding antitumor capacity of CD4+ T helper lymphocytes

2020 ◽  
Vol 1874 (2) ◽  
pp. 188439
Author(s):  
Tong Li ◽  
Bowen Wu ◽  
Tao Yang ◽  
Long Zhang ◽  
Ke Jin
Keyword(s):  
T Helper ◽  
T Helper Lymphocytes

scholarly journals APOPTOSIS, MEMORY CELL, AND T-HELPER LYMPHOCYTES BALANCE BETWEEN SEVERE AND MILD BRONCHIAL ASTHMA

2015 ◽  
Vol 21 (4) ◽  
pp. 1-13
Author(s):  
Maha Abd El-wahed ◽  
Ebtesam Ahmed ◽  
Mohamed Mohamed ◽  
Nora Said
Keyword(s):  
Bronchial Asthma ◽  
Memory Cell ◽  
T Helper ◽  
T Helper Lymphocytes ◽  
Mild Bronchial Asthma

Altered Expressions of CXCR4 and CD26 On T-Helper Lymphocytes in Hereditary Hemorrhagic Telangiectasia

2021 ◽  
Author(s):  
Alexandre GUILHEM ◽  
Pierre Portalès ◽  
Sophie Dupuis-Girod ◽  
Sophie Rivière ◽  
Thierry Vincent
Keyword(s):  
Hereditary Hemorrhagic Telangiectasia ◽  
Severe Infection ◽  
Intravenous Iron ◽  
Surface Expression ◽  
T Helper ◽  
Membrane Expression ◽  
Susceptibility To Infection ◽  
T Helper Lymphocytes ◽  
Infectious Risk ◽  
Healthy Control

Abstract Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease characterized by a deregulated neo-angiogenesis. Besides a mainly vascular phenotype (telangiectasia, arteriovenous malformations), patients exhibit a specific infectious risk and a deficit of T and natural killer (NK) lymphocytes. As the CXCR4/CXCL12 chemotactic axis is dysregulated in HHT endothelial cells, we hypothesized that a similar phenomenon could occur on lymphocytes.Results: Eighteen HHT patients with history of severe infection (HSI) were matched in age and sex with 18 HHT without HSI and 18 healthy control subjects (HC). We assessed the cell count and the surface expression of CXCR4 and CD26 (CXCL12 inactivating peptidase) of circulating helper and cytotoxic T lymphocytes (including naive, memory and activated subsets) and NK cells.The overall HHT group of 36 patients exhibited a reduction of circulating T-helper lymphocytes compared to HC (median: 517 vs 1026 cells/mm3, p<0.0001), correlated with age (r=-0.46, p=0.005), requirement of intravenous iron or blood transfusions (median: 291 vs 627 cells/mm3, p=0.03) and CXCR4 surface expression (r=0.353, p=0.0345). CXCR4 and CD26 membrane expression were both decreased on HHT T-helper lymphocytes (median MFI ratio: 4.49 vs 5.74 for CXCR4 and 3.21 vs 4.33 for CD26, p=0.03 and 0.0018 respectively) with an unchanged CXCR4/CD26 ratio. The HHT group with HSI had a higher CXCR4/CD26 ratio on the naive T-helper lymphocytes (median: 2.34 vs 1.32, p=0.0002), also observed on the T and T-helper populations.Conclusions: Our findings support a dysregulation of the CXCL12/CXCR4 chemotaxis of T-helper lymphocytes in HHT patients, potentially linked to their T-helper lymphopenia and susceptibility to infection.

scholarly journals Transcription Factor Ets-2 Acts as a Preinduction Repressor of Interleukin-2 (IL-2) Transcription in Naive T Helper Lymphocytes

2016 ◽  
Vol 291 (52) ◽  
pp. 26707-26721 ◽  
Author(s):  
Ioannis Panagoulias ◽  
Tassos Georgakopoulos ◽  
Ioanna Aggeletopoulou ◽  
Marios Agelopoulos ◽  
Dimitris Thanos ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Interleukin 2 ◽  
T Helper ◽  
T Helper Lymphocytes

scholarly journals Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation

2019 ◽  
Vol 71 (10) ◽  
pp. 1756-1765 ◽  
Author(s):  
Kristyna Hradilkova ◽  
Patrick Maschmeyer ◽  
Kerstin Westendorf ◽  
Heidi Schliemann ◽  
Olena Husak ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chronic Inflammation ◽  
Fatty Acid Oxidation ◽  
Metabolic Adaptation ◽  
Acid Oxidation ◽  
T Helper ◽  
T Helper Lymphocytes ◽  
Twist 1

Immunological aspects of urethral stenosis. Involvement of the S100 protein-positive dendritic cells

1995 ◽  
Vol 62 (1_suppl) ◽  
pp. 53-58
Author(s):  
C. Cracco ◽  
S. Biasiol ◽  
G. Filogamo ◽  
S. Rocca Rossetti
Keyword(s):  
Dendritic Cells ◽  
Immune System ◽  
Morphological Changes ◽  
S100 Protein ◽  
Healthy Skin ◽  
T Helper ◽  
Urethral Stenosis ◽  
T Helper Lymphocytes ◽  
Accessory Cells ◽  
Dermatological Disorders

— Within the superficial layers of healthy skin and of some mucosae there is a Population of accessory cells of the immune system, able to interact with T helper lymphocytes. Such cells, called tissular dendritic cells (DCs), increase their density and display different morphological features in a variety of immunologically-mediated dermatological disorders. In the present work we investigated DCs within the various urethral segments, both in normal conditions and in urethral stenosis. The specimens, obtained from urethrectomies and urethroplasties with end-to-end anastomosis, were stained with anti-S100 protein antibody and immunofluorescence techniques. We demonstrated an increasing density of S100 protein-positive epithelial DCs from the Prostatic urethra to the glandular one, where DCs were also larger and richer in dendritic Processes. In urethral stenosis the intraepithelial infiltrate of ramified DCs was much denser than any other control. We therefore hypothesize a role for the immune system in the development and maintenance of urethral stenoses, where, as already demonstrated for other types of pathological scarring, morphological changes of DCs serve as clues to their functional activation.

scholarly journals R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome

2018 ◽  
Vol 142 (1) ◽  
pp. 219-234 ◽  
Author(s):  
Koustav Sarkar ◽  
Seong-Su Han ◽  
Kuo-Kuang Wen ◽  
Hans D. Ochs ◽  
Loïc Dupré ◽  
...  
Keyword(s):  
Genomic Instability ◽  
T Helper ◽  
Wiskott Aldrich Syndrome ◽  
T Helper Lymphocytes

Preferential and persistent depletion of CCR5+T-helper lymphocytes with nonlymphoid homing potential despite early treatment of primary HIV infection

Blood ◽  
2001 ◽  
Vol 98 (10) ◽  
pp. 3169-3171 ◽  
Author(s):  
Roman Krzysiek ◽  
Annick Rudent ◽  
Laurence Bouchet-Delbos ◽  
Arnaud Foussat ◽  
Claudie Boutillon ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Protective Immunity ◽  
Immune Functions ◽  
T Helper ◽  
Primary Hiv Infection ◽  
T Helper Lymphocytes ◽  
Immunodeficiency Virus ◽  
Nonlymphoid Tissue ◽  
Th Lymphocytes

Abstract Strains of human immunodeficiency virus (HIV) transmitted between individuals use the CCR5 coreceptor, but no preferential depletion of particular Th-lymphocyte subpopulations has been reported during primary HIV infection (PHI). In contrast, gut-associated Th lymphocytes are preferentially depleted in macaques recently infected by simian immunodeficiency virus. The expression of CCR5 and the intestinal homing receptor integrin α4β7 on subpopulations of Th lymphocytes was studied in 12 patients with PHI. There was a profound decrease of circulating α4β7+ Th lymphocytes and CCR5+ memory Th lymphocytes with nonlymphoid homing potential (CD62L−CD45RO+). Unlike other Th lymphocytes, this cell population remained depleted despite early control of viral replication under antiretroviral treatment. Therefore, HIV preferentially targets a specific CCR5+ subpopulation of Th lymphocytes early during infection, inducing its persistent depletion despite treatment. Protective immunity in vivo depends on Th lymphocytes carrying homing capacity to nonlymphoid tissue, and therefore these data may explain the persistent abnormalities of immune functions in patients infected with HIV.

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