scholarly journals Risk Factors for Graft-Versus-Host Disease (GVHD) in Haploidentical Hematopoietic Cell Transplantation (HCT) Using Post-Transplant Cyclophosphamide (PTCy)

2019 ◽  
Vol 25 (3) ◽  
pp. S256
Author(s):  
Armin Rashidi ◽  
Betty K. Hamilton ◽  
Tao Wang ◽  
Michael T. Hemmer ◽  
Stephen R. Spellman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Host Disease ◽  
Graft Versus Host ◽  
Post Transplant ◽  
Haploidentical Hematopoietic Cell Transplantation

Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation

Blood ◽  
2004 ◽  
Vol 104 (6) ◽  
pp. 1894-1897 ◽  
Author(s):  
Kristina M. Adams ◽  
Leona A. Holmberg ◽  
Wendy Leisenring ◽  
Alexander Fefer ◽  
Katherine A. Guthrie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Interleukin 2 ◽  
Hematopoietic Cell ◽  
Independent Effect ◽  
Host Disease ◽  
Graft Versus Host ◽  
Primary Focus

Abstract Syngeneic graft-versus-host disease (sGVHD) has been described after hematopoietic cell transplantation (HCT) but remains poorly defined. We retrospectively reviewed adult syngeneic HCTs at our center (1980-2002) for sGVHD to investigate incidence, morbidity, and risk factors with a primary focus on parity. Among 119 transplantations, there were 21 cases of biopsy-proven sGVHD. The cumulative incidence was 18%, with multiorgan involvement in 6 cases and 1 death. sGVHD was more frequent when the donor was parous (32%) than nulliparous (9%) or male (13%; P = .03) and when the recipient was parous (31%) than nulliparous (7%) or male (13%; P = .02). Other univariable risk factors included older age (P < .01), busulfan/melphalan/thiotepa conditioning (P < .01), interleukin-2 (P = .02), HLA-A26 (P = .03), and more recent transplantation year (P < .01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation.

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