Modulation of the effects of the cannabinoid agonist, ACPA, on spatial and non-spatial novelty detection in mice by dopamine D1 receptor drugs infused into the basolateral amygdala

2015 ◽  
Vol 280 ◽  
pp. 36-44 ◽  
Author(s):  
Meisam Mohammadi ◽  
Mohammad Nasehi ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Basolateral Amygdala ◽  
Novelty Detection ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Spatial Novelty ◽  
Cannabinoid Agonist

D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine

2011 ◽  
Vol 26 (4) ◽  
pp. 564-574 ◽  
Author(s):  
Maryam Bananej ◽  
Ahmad Karimi-Sori ◽  
Mohammad Reza Zarrindast ◽  
Shamseddin Ahmadi
Keyword(s):  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Basolateral Amygdala ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Dopamine D2 ◽  
D1 And D2 Receptors ◽  
Male Wistar Rats

Involvement of the dopamine receptors in the basolateral amygdala (BLA) in the effects of histamine on anxiety-like behaviors of the elevated plus maze in male Wistar rats was investigated. The results showed that bilateral intra-BLA injections of histamine (2.5, 5 and 7.5 µg/rat) induced an anxiogenic-like effect, revealed by decreases in percentage of open arm time (%OAT) and open arm entries (%OAE). Intra-BLA administration of dopamine D1 receptor agonist, SKF38393 (0.25 µg/rat), and dopamine D2 receptor agonist, quinpirole (0.03 and 0.05 µg/rat), decreased %OAT but not %OAE. Conversely, intra-BLA administration of dopamine D1 receptor antagonist, SCH23390 (0.5 and 1 µg/rat), and dopamine D2 receptor antagonist, sulpiride (0.3 and 0.5 µg/rat), increased %OAT and %OAE, suggesting an anxiolytic-like effect for both drugs. Interestingly, co-administration of a silent dose of SCH23390 or sulpiride prevented anxiogenic-like effects of SKF38393 and quinpirole, respectively. Conjoint administration of a sub-effective dose of SKF38393 (0.125 µg/rat) or quinpirole (0.01 µg/rat) along with lower doses of histamine (1 and 2.5 µg/rat) induced anxiolytic-like effects. On the other hand, intra-BLA pretreatment with a silent dose of SCH23390 (0.25 µg/rat) or sulpiride (0.1 µg/rat) prevented the anxiogenic-like effect of higher doses of histamine (5 and 7.5 µg/rat). No significant change was observed in total closed arm entries, as an index for motor activity of the animals. It can be concluded that the dopamine D1 and D2 receptors in the BLA may be involved in the anxiogenic-like effects induced by histamine.

scholarly journals Dopamine D1 Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

2008 ◽  
Vol 28 (50) ◽  
pp. 13390-13400 ◽  
Author(s):  
A. H. Tran ◽  
T. Uwano ◽  
T. Kimura ◽  
E. Hori ◽  
M. Katsuki ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Spatial Novelty

Dopamine D1 Receptor Within Basolateral Amygdala Is Involved in Propofol Relapse Behavior Induced by Cues

2018 ◽  
Vol 43 (12) ◽  
pp. 2393-2403 ◽  
Author(s):  
Sicong Wang ◽  
Xin Wang ◽  
Wenxuan Lin ◽  
Suhao Bao ◽  
Benfu Wang ◽  
...  
Keyword(s):  
Basolateral Amygdala ◽  
Dopamine D1 Receptor ◽  
D1 Receptor

scholarly journals Dopamine D1 receptor‐expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine

2021 ◽  
Author(s):  
Yukari Nakamura ◽  
Sophie Longueville ◽  
Akinori Nishi ◽  
Denis Herve ◽  
Jean‐Antoine Girault ◽  
...  
Keyword(s):  
Single Injection ◽  
Dopamine D1 Receptor ◽  
D1 Receptor

Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression

2021 ◽  
Author(s):  
Hong-Rui Meng ◽  
Toshiko Suenaga ◽  
Mitsuhiro Edamura ◽  
Atsuo Fukuda ◽  
Yasushi Ishida ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Expression

scholarly journals Serine mutations in transmembrane V of the dopamine D1 receptor affect ligand interactions and receptor activation.

1992 ◽  
Vol 267 (25) ◽  
pp. 17780-17786
Author(s):  
N.J. Pollock ◽  
A.M. Manelli ◽  
C.W. Hutchins ◽  
M.E. Steffey ◽  
R.G. MacKenzie ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Ligand Interactions

scholarly journals Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3799
Author(s):  
Tim J. Fyfe ◽  
Peter J. Scammells ◽  
J. Robert Lane ◽  
Ben Capuano
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Intrinsic Activity ◽  
Optical Isomers ◽  
Allosteric Modulators ◽  
Disease States ◽  
Starting Point ◽  
Significant Difference ◽  
Optically Pure ◽  
Allosteric Properties

(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intrinsic activity, compound 2 shows promise as a starting point toward the development of small molecule allosteric modulators to ameliorate the cognitive deficits associated with some neuropsychiatric disease states; (2) Methods: Herein, we describe the enantioenrichment of optical isomers of 2 using chiral auxiliaries derived from (R)- and (S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (d- and l-pantolactone, respectively); (3) Results: We confirm both the racemate and enantiomers of 2 are active and selective for the D1R, but that the respective stereoisomers show a significant difference in their affinity and magnitude of positive allosteric cooperativity with dopamine; (4) Conclusions: These data warrant further investigation of asymmetric syntheses of optically pure analogues of 2 for the development of D1R PAMs with superior allosteric properties.

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