The primary motor cortex electrical and chemical stimulation attenuates the chronic neuropathic pain by activation of the periaqueductal gray matter: The Role of NMDA receptors

2021 ◽  
pp. 113522
Author(s):  
Sylmara Esther Negrini-Ferrari ◽  
Priscila Medeiros ◽  
Rafael Braghetto Malvestio ◽  
Mariana de Oliveira Silva ◽  
Ana Carolina Medeiros ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Motor Cortex ◽  
Nmda Receptors ◽  
Gray Matter ◽  
Primary Motor Cortex ◽  
Periaqueductal Gray ◽  
Chemical Stimulation ◽  
Chronic Neuropathic Pain ◽  
Periaqueductal Gray Matter

scholarly journals Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Igor Lavrov ◽  
Timur Latypov ◽  
Elvira Mukhametova ◽  
Brian Lundstrom ◽  
Paola Sandroni ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cerebral Cortex ◽  
Motor Cortex ◽  
Initial Assessment ◽  
Motor Cortex Stimulation ◽  
Chronic Neuropathic Pain ◽  
Long Term Effect ◽  
Stimulation Of

AbstractElectrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.

Microinjection of opiates into the periaqueductal gray matter attenuates neuropathic pain symptoms in rats

Neuroreport ◽  
2000 ◽  
Vol 11 (7) ◽  
pp. 1413-1416 ◽  
Author(s):  
Jin-Hun Sohn ◽  
Bae Hwan Lee ◽  
Se Hun Park ◽  
Jae-Wook Ryu ◽  
Bong-Ok Kim ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Gray Matter ◽  
Periaqueductal Gray ◽  
Periaqueductal Gray Matter ◽  
Pain Symptoms

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT2Aand 5-HT2Cserotonergic receptors in post-ictal antinociception

Synapse ◽  
2013 ◽  
Vol 68 (1) ◽  
pp. 16-30 ◽  
Author(s):  
Renato Leonardo de Freitas ◽  
Rithiele Cristina de Oliveira ◽  
Ricardo de Oliveira ◽  
Tatiana Paschoalin-Maurin ◽  
Fernando Morgan de Aguiar Corrêa ◽  
...  
Keyword(s):  
Gray Matter ◽  
Periaqueductal Gray ◽  
Periaqueductal Gray Matter
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