scholarly journals G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice

2015 ◽  
Vol 459 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Akinori Shimizu ◽  
Takayuki Mito ◽  
Osamu Hashizume ◽  
Hiromichi Yonekawa ◽  
Kaori Ishikawa ◽  
...  
Keyword(s):  
Late Onset ◽  
Late Onset Disorders

scholarly journals Calculating risk changes after negative mutation test outcomes for autosomal dominant hereditary late-onset disorders

Heredity ◽  
2006 ◽  
Vol 96 (3) ◽  
pp. 259-261 ◽  
Author(s):  
B Bonke ◽  
A Tibben ◽  
D Lindhout ◽  
T Stijnen
Keyword(s):  
Autosomal Dominant ◽  
Late Onset ◽  
Test Outcomes ◽  
Late Onset Disorders

scholarly journals Predicting adaptation to presymptomatic DNA testing for late onset disorders: who will experience distress? Rotterdam Leiden Genetics Workgroup.

1998 ◽  
Vol 35 (9) ◽  
pp. 745-754 ◽  
Author(s):  
A C DudokdeWit ◽  
A Tibben ◽  
H J Duivenvoorden ◽  
M F Niermeijer ◽  
J Passchier
Keyword(s):  
Late Onset ◽  
Dna Testing ◽  
Late Onset Disorders

scholarly journals DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

2021 ◽  
Vol 22 (8) ◽  
pp. 4244
Author(s):  
Virginia Veronica Visconti ◽  
Ida Cariati ◽  
Simona Fittipaldi ◽  
Riccardo Iundusi ◽  
Elena Gasbarra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Late Onset ◽  
Bone Diseases ◽  
Epigenetic Mechanisms ◽  
Crucial Point ◽  
Pathological Conditions ◽  
New Findings ◽  
Late Onset Disorders

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.

Sign in / Sign up

Export Citation Format

Share Document