Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development

2021 ◽  
Vol 534 ◽  
pp. 752-757
Author(s):  
Mizuki Wakabayashi ◽  
Shiori Tamura ◽  
Satoko Kanzaki ◽  
Mayuko Kosugi ◽  
Yuki Yoshimura ◽  
...  
Keyword(s):  
Gene Family ◽  
Mouse Development ◽  
Maternal To Zygotic Transition ◽  
Multicopy Gene

A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region

1993 ◽  
Vol 38 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Corine Vernet ◽  
Marie-Th�r�se Ribouchon ◽  
Giovanna Chimini ◽  
Anne-Marie Jouanolle ◽  
Issa Sidib� ◽  
...  
Keyword(s):  
Gene Family ◽  
Mhc Class I ◽  
Class I ◽  
Coding Sequence ◽  
Multicopy Gene ◽  
Class I Region

The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development

1992 ◽  
Vol 226 (3) ◽  
pp. 747-761 ◽  
Author(s):  
L. Foroni ◽  
T. Boehm ◽  
L. White ◽  
A. Forster ◽  
P. Sherrington ◽  
...  
Keyword(s):  
Gene Family ◽  
Multiple Roles ◽  
Lim Domain ◽  
Mouse Development

scholarly journals Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Katia Ancelin ◽  
Laurène Syx ◽  
Maud Borensztein ◽  
Noémie Ranisavljevic ◽  
Ivaylo Vassilev ◽  
...  
Keyword(s):  
Transcriptional Level ◽  
Mouse Development ◽  
Cell Stage ◽  
Genome Expression ◽  
Maternal To Zygotic Transition ◽  
Histone H3k4 ◽  
Histone Modifying Enzymes ◽  
Early Mouse ◽  
Methylation Patterns ◽  
Genome Activation

Upon fertilization, the highly specialised sperm and oocyte genomes are remodelled to confer totipotency. The mechanisms of the dramatic reprogramming events that occur have remained unknown, and presumed roles of histone modifying enzymes are just starting to be elucidated. Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development. KDM1A deficiency results in developmental arrest by the two-cell stage, accompanied by dramatic and stepwise alterations in H3K9 and H3K4 methylation patterns. At the transcriptional level, the switch of the maternal-to-zygotic transition fails to be induced properly and LINE-1 retrotransposons are not properly silenced. We propose that KDM1A plays critical roles in establishing the correct epigenetic landscape of the zygote upon fertilization, in preserving genome integrity and in initiating new patterns of genome expression that drive early mouse development.

scholarly journals Multicopy gene family evolution on primate Y chromosomes

BMC Genomics ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Ana-Hermina Ghenu ◽  
Benjamin M. Bolker ◽  
Don J. Melnick ◽  
Ben J. Evans
Keyword(s):  
Gene Family ◽  
Gene Family Evolution ◽  
Y Chromosomes ◽  
Multicopy Gene

scholarly journals Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes

1989 ◽  
Vol 17 (10) ◽  
pp. 3829-3843 ◽  
Author(s):  
Ans M.W. Van den Ouweland ◽  
Hans L.P. Van Duijnhoven ◽  
Klaus A. Deichmann ◽  
Jan J.M. Van Groningen ◽  
Lou de Leij ◽  
...  
Keyword(s):  
Gene Family ◽  
Multicopy Gene ◽  
Processed Pseudogenes

The high affinity murine laminin receptor is a member of a multicopy gene family

1991 ◽  
Vol 175 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Maria-Teresa Fernández ◽  
Vincent Castronovo ◽  
C.N. Rao ◽  
Mark E. Sobel
Keyword(s):  
Gene Family ◽  
Laminin Receptor ◽  
High Affinity ◽  
Multicopy Gene

Characteristisc of a multicopy gene family predominantly consisting of processed pseudogeneses

1989 ◽  
Vol 27 ◽  
pp. 206
Author(s):  
A.M.W. v.d. Ouweland ◽  
H.L.P. v. Duijnhoven ◽  
K.A. Deichmann ◽  
J.J.M. v. Groningen ◽  
L. d. Leij ◽  
...  
Keyword(s):  
Gene Family ◽  
Multicopy Gene
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