Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: Role of the farnesoid X receptor

2005 ◽  
Vol 69 (12) ◽  
pp. 1755-1763 ◽  
Author(s):  
Gabriele Campana ◽  
Patrizia Pasini ◽  
Aldo Roda ◽  
Santi Spampinato
Keyword(s):  
Bile Acid ◽  
Protein Expression ◽  
Ursodeoxycholic Acid ◽  
Binding Protein ◽  
Farnesoid X Receptor ◽  
Acid Binding Protein ◽  
Bile Acid Binding

Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor

2002 ◽  
Vol 122 (5) ◽  
pp. 1483-1492 ◽  
Author(s):  
Sandy T. Hwang ◽  
Nancy L. Urizar ◽  
David D. Moore ◽  
Susan J. Henning
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Binding Protein ◽  
Farnesoid X Receptor ◽  
Acid Binding Protein ◽  
Bile Acid Binding ◽  
Ontogenic Expression

Hormonal regulation of expression of ileal bile acid binding protein in suckling rats

2000 ◽  
Vol 278 (6) ◽  
pp. R1555-R1563 ◽  
Author(s):  
Sandy T. Hwang ◽  
Susan J. Henning
Keyword(s):  
Bile Acid ◽  
Hormonal Regulation ◽  
Normal Development ◽  
Binding Protein ◽  
Secondary Response ◽  
Regulation Of Expression ◽  
Acid Binding Protein ◽  
Bile Acid Binding ◽  
Developing Rat

Ileal bile acid binding protein (IBABP) is a cytosolic protein believed to be involved in the absorption of conjugated bile acids. In rodents this protein and its mRNA have been shown to increase markedly during the third postnatal week. Because this period of ontogeny is characterized by increasing circulating concentrations of glucocorticoids and thyroxine, the goal of our study was to investigate the role of these hormones in IBABP expression in the developing rat. Administration of various doses of dexamethasone (Dex) during the second postnatal week caused a robust induction of IBABP mRNA and protein. Plateau levels of IBABP mRNA occurred at a Dex dose of 0.1 μg/g body wt, which is within the physiological range. IBABP mRNA was not appreciably induced until 24 h after treatment, suggesting that glucocorticoids influence IBABP either through a delayed primary or a secondary response mechanism. The regional pattern of IBABP mRNA elicited by Dex mimicked that seen during normal development, with appearance in distal ileum preceding proximal ileum. Thyroxine injections did not result in a significant increase of IBABP mRNA, and synergism between Dex and thyroxine was not observed. Taken together, our data suggest that maturation of IBABP expression is influenced by glucocorticoids but not by thyroxine.

Structural and dynamic roles of permanent water molecules in ligand molecular recognition by chicken liver bile acid binding protein

2008 ◽  
Vol 21 (5) ◽  
pp. 348-354 ◽  
Author(s):  
Piero Ricchiuto ◽  
Alessandro Guerini Rocco ◽  
Elisabetta Gianazza ◽  
Dario Corrada ◽  
Tiziana Beringhelli ◽  
...  
Keyword(s):  
Bile Acid ◽  
Molecular Recognition ◽  
Binding Protein ◽  
Chicken Liver ◽  
Water Molecules ◽  
Acid Binding Protein ◽  
Bile Acid Binding

NMR unfolding studies on a liver bile acid binding protein reveal a global two-state unfolding and localized singular behaviors

2009 ◽  
Vol 481 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Mariapina D’Onofrio ◽  
Laura Ragona ◽  
Dimitrios Fessas ◽  
Marco Signorelli ◽  
Raffaella Ugolini ◽  
...  
Keyword(s):  
Bile Acid ◽  
Binding Protein ◽  
Acid Binding Protein ◽  
Bile Acid Binding

scholarly journals Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

1999 ◽  
Vol 274 (42) ◽  
pp. 29749-29754 ◽  
Author(s):  
Jacques Grober ◽  
Isabelle Zaghini ◽  
Hiroshi Fujii ◽  
Stacey A. Jones ◽  
Steven A. Kliewer ◽  
...  
Keyword(s):  
Bile Acid ◽  
Protein Gene ◽  
Binding Protein ◽  
Acid Binding Protein ◽  
Bile Acid Binding ◽  
Binding Protein Gene ◽  
Responsive Element

Bile Acid Binding Protein Functionalization Leads to a Fully Synthetic Rhodopsin Mimic

2019 ◽  
Vol 10 (9) ◽  
pp. 2235-2243 ◽  
Author(s):  
Katiuscia Pagano ◽  
Marco Paolino ◽  
Stefania Fusi ◽  
Vinicio Zanirato ◽  
Claudio Trapella ◽  
...  
Keyword(s):  
Bile Acid ◽  
Binding Protein ◽  
Acid Binding Protein ◽  
Bile Acid Binding ◽  
Protein Functionalization

scholarly journals Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

FEBS Journal ◽  
2016 ◽  
Vol 283 (3) ◽  
pp. 541-555 ◽  
Author(s):  
Gergő Horváth ◽  
Ákos Bencsura ◽  
Ágnes Simon ◽  
Gregory P. Tochtrop ◽  
Gregory T. DeKoster ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ligand Binding ◽  
Ternary Complex ◽  
Binding Protein ◽  
Solution Nmr ◽  
Structural Determinants ◽  
Acid Binding Protein ◽  
Bile Acid Binding
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