Knockdown of integrin β4 in primary cultured mouse neurons blocks survival and induces apoptosis by elevating NADPH oxidase activity and reactive oxygen species level

2008 ◽  
Vol 40 (4) ◽  
pp. 689-699 ◽  
Author(s):  
Xin Lv ◽  
Le Su ◽  
Deling Yin ◽  
Chunhui Sun ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Reactive Oxygen ◽  
Species Level ◽  
Reactive Oxygen Species Level ◽  
Oxygen Species ◽  
Nadph Oxidase Activity ◽  
Integrin Β4

Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen

2010 ◽  
Vol 40 (13) ◽  
pp. 1531-1538 ◽  
Author(s):  
Natalia Guiñazú ◽  
Eugenio Antonio Carrera-Silva ◽  
María Cecilia Becerra ◽  
Andrea Pellegrini ◽  
Inés Albesa ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Trypanosoma Cruzi ◽  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nadph Oxidase Activity ◽  
Species Production

D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure

2006 ◽  
Vol 290 (1) ◽  
pp. R96-R104 ◽  
Author(s):  
Zhiwei Yang ◽  
Laureano D. Asico ◽  
Peiying Yu ◽  
Zheng Wang ◽  
John E. Jones ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Reactive Oxygen ◽  
Receptor Activation ◽  
Oxidase Inhibitor ◽  
Ros Production ◽  
Oxygen Species ◽  
Nadph Oxidase Activity

Activation of D1-like receptors (D1 and/or D5) induces antioxidant responses; however, the mechanism(s) involved in their antioxidant actions are not known. We hypothesized that stimulation of the D5 receptor inhibits NADPH oxidase activity, and thus the production of reactive oxygen species (ROS). We investigated this issue in D5 receptor-deficient (D5−/−) and wild-type (D5+/+) mice. NADPH oxidase protein expression (gp91phox, p47phox, and Nox 4) and activity in kidney and brain, as well as plasma thiobarbituric acid-reactive substances (TBARS) were higher in D5−/− than in D5+/+ mice. Furthermore, apocynin, an NADPH oxidase inhibitor, normalized blood pressure, renal NADPH oxidase activity, and plasma TBARS in D5−/− mice. In HEK-293 cells that heterologously expressed human D5 receptor, its agonist fenoldopam decreased NADPH oxidase activity, expression of one of its subunits (gp91phox), and ROS production. The inhibitory effect of the D5 receptor activation on NADPH oxidase activity was independent of cAMP/PKA but was partially dependent on phospholipase D2. The ability of D5 receptor stimulation to decrease ROS production may explain, in part, the antihypertensive action of D5 receptor activation.

Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils

2013 ◽  
Vol 206 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Sandrine Derochette ◽  
Thierry Franck ◽  
Ange Mouithys-Mickalad ◽  
Justine Ceusters ◽  
Ginette Deby-Dupont ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nadph Oxidase Activity

Modulation of Intracellular Reactive Oxygen Species Level in Chondrocytes by IGF-1, FGF, and TGF-β1

2007 ◽  
Vol 48 (3) ◽  
pp. 149-158 ◽  
Author(s):  
Navid Jallali ◽  
Hyder Ridha ◽  
Christopher Thrasivoulou ◽  
Peter Butler ◽  
Timothy Cowen
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Species Level ◽  
Reactive Oxygen Species Level ◽  
Oxygen Species ◽  
Tgf Β1
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