IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration

2021 ◽  
pp. 106093
Author(s):  
Sveta Padmanabhan ◽  
Bijaya Gaire ◽  
Yue Zou ◽  
Mohammad M. Uddin ◽  
Daniel DeLeon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells

scholarly journals Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells

2017 ◽  
Vol 292 (12) ◽  
pp. 5043-5054 ◽  
Author(s):  
Himavanth R. Gatla ◽  
Yue Zou ◽  
Mohammad M. Uddin ◽  
Bipradeb Singha ◽  
Pengli Bu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells ◽  
Hdac Inhibition ◽  
Iκb Kinase

scholarly journals Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes Ovarian Cancer Cell Stemness and Malignancy Through the Notch3-Mediated Signaling

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhaodong Ji ◽  
Wenjuan Tian ◽  
Wen Gao ◽  
Rongyu Zang ◽  
Huaying Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Tumor Development ◽  
Underlying Mechanism ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells ◽  
Multiple Cancer ◽  
Ovarian Tumorigenesis

As a significant component in ovarian cancer microenvironment, cancer-associated fibroblasts (CAFs) contribute to cancer progression through interaction with cancer cells. Recent studies demonstrate that interleukin-8 (IL-8) is overexpressed in multiple cancer types and is essential for tumor development. Nonetheless, the underlying mechanism that the CAF-derived IL-8 promotes ovarian tumorigenesis is unknown. Here, we show that IL-8 secreted from CAFs could activate normal ovarian fibroblasts (NFs) through multiple signaling and that IL-8 stimulated malignant growth of ovarian cancer cells in animals and increased the IC50 of cisplatin (CDDP) in ovarian cancer cells. Further study showed that IL-8 induced cancer cell stemness via the activation of Notch3 and that the high level of IL-8 in ascites was positively correlated with the expression of Notch3 in ovarian cancer tissues. Collectively, IL-8 secreted from CAFs and cancer cells promotes stemness in human ovarian cancer via the activation of the Notch3-mediated signaling, which may provide a novel strategy for ovarian cancer treatment.

scholarly journals Interleukin‑8 released by cancer‑associated fibroblasts attenuates the autophagy and promotes the migration of ovarian cancer cells

2021 ◽  
Vol 58 (5) ◽  
Author(s):  
Suyanee Thongchot ◽  
Pranisa Jamjuntra ◽  
Suwanit Therasakvichya ◽  
Malee Warnnissorn ◽  
Alessandra Ferraresi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells ◽  
Cancer Associated Fibroblasts

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 ◽  
Vol 81 (2) ◽  
pp. 291-300 ◽  
Author(s):  
Benjamin M. Schwartz ◽  
Guiying Hong ◽  
Bei H. Morrison ◽  
Weihua Wu ◽  
Linnea M. Baudhuin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells

Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells

Cytokine ◽  
2011 ◽  
Vol 56 (2) ◽  
pp. 365-375 ◽  
Author(s):  
Yue Wang ◽  
Ye Qu ◽  
Xiu Long Niu ◽  
Wei Jia Sun ◽  
Xiao Lei Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Interleukin 8 ◽  
Ovarian Cancer Cells ◽  
Paclitaxel Resistance

scholarly journals Epigenetic regulation of interleukin-8 expression by class I HDAC and CBP in ovarian cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 70798-70810 ◽  
Author(s):  
Himavanth R. Gatla ◽  
Yue Zou ◽  
Mohammad M. Uddin ◽  
Ivana Vancurova
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Epigenetic Regulation ◽  
Interleukin 8 ◽  
Class I ◽  
Ovarian Cancer Cells

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects
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