scholarly journals Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats

Biomaterials ◽  
2018 ◽  
Vol 168 ◽  
pp. 24-37 ◽  
Author(s):  
Rui Li ◽  
Yiyang Li ◽  
Yanqing Wu ◽  
Yingzheng Zhao ◽  
Huanwen Chen ◽  
...  
2012 ◽  
Vol 72 (1) ◽  
pp. 199-205 ◽  
Author(s):  
Chun-Hsu Yao ◽  
Ruey-Lin Chang ◽  
Shih-Liang Chang ◽  
Chin-Chuan Tsai ◽  
Fuu-Jen Tsai ◽  
...  

2015 ◽  
Vol 43 (02) ◽  
pp. 215-230 ◽  
Author(s):  
Han-Chung Lee ◽  
Yuan-Man Hsu ◽  
Chin-Chuan Tsai ◽  
Cherng-Jyh Ke ◽  
Chun-Hsu Yao ◽  
...  

We assessed the therapeutic effects of lumbrokinase, a group of enzymes extracted from the earthworm, on peripheral-nerve regeneration using well-defined sciatic nerve lesion paradigms in diabetic rats induced by the injection of streptozotocin (STZ). We found that lumbrokinase therapy could improve the rats' circulatory blood flow and promote the regeneration of axons in a silicone rubber conduit after nerve transection. Lumbrokinase treatment could also improve the neuromuscular functions with better nerve conductive performances. Immunohistochemical staining showed that lumbrokinase could dramatically promote calcitonin gene-related peptide (CGRP) expression in the lamina I–II regions in the dorsal horn ipsilateral to the injury and cause a marked increase in the number of macrophages recruited within the distal nerve stumps. In addition, the lumbrokinase could stimulate the secretion of interleukin-1 (IL-1), nerve growth factor (NGF), platelet-derived growth factor (PDGF), and transforming growth factor-β (TGF-β) in dissected diabetic sciatic nerve segments. In conclusion, the administration of lumbrokinase after nerve repair surgery in diabetic rats was found to have remarkable effects on promoting peripheral nerve regeneration and functional recovery.


1997 ◽  
Vol 759 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Vrijesh S Tantuwaya ◽  
Sean B Bailey ◽  
Robert E Schmidt ◽  
Aida Villadiego ◽  
Jianxin X Tong ◽  
...  

2014 ◽  
Vol 32 (3) ◽  
pp. 437-446 ◽  
Author(s):  
Yu-Ching Lin ◽  
Chia-Hong Kao ◽  
Yu-Kai Cheng ◽  
Jia-Jin J. Chen ◽  
Chun-Hsu Yao ◽  
...  

2021 ◽  
Vol 6 (11) ◽  
pp. 3892-3903
Author(s):  
Can Liu ◽  
Lei Fan ◽  
Zhenming Tian ◽  
Huiquan Wen ◽  
Lei Zhou ◽  
...  

2017 ◽  
Author(s):  
M. Karagyaur ◽  
P. Makarevich ◽  
E. Shevchenko ◽  
D. Stambolsky ◽  
N. Kalinina ◽  
...  

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