Quinazoline-4(3H)-one derivatives as novel and potent inhibitors of soluble epoxide hydrolase: Design, synthesis and biological evaluation

2020 ◽  
Vol 99 ◽  
pp. 103736
Author(s):  
Leila Hejazi ◽  
Elham Rezaee ◽  
Sayyed Abbas Tabatabai
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Novel soluble epoxide hydrolase inhibitors with a dihydropyrimidinone scaffold: design, synthesis and biological evaluation

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2128-2135 ◽  
Author(s):  
Elham Rezaee ◽  
Mahdi Hedayati ◽  
Laleh Hoghooghi Rad ◽  
Soraya Shahhosseini ◽  
Mehrdad Faizi ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Scaffold Design ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Synthesis And Biological Evaluation

Amide non-urea derivatives with a dihydropyrimidinone ring as a novel secondary pharmacophore against the sEH enzyme were designed, synthesized and biologically evaluated.

scholarly journals Synthesis and biological evaluation of soluble epoxide hydrolase (sEH) inhibitors: t‐AUCB and its derivatives

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
SUNG HEE HWANG ◽  
Hsing‐Ju Tsai ◽  
Christophe Morisseau ◽  
Jun‐Yan Liu ◽  
Bruce D. Hammock
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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